Thursday, September 22, 2005

Cancion® CRS™ Cardiac Recovery System

Filed under: Cardiac Surgery

10News KGTV, San Diego reports that the UCSD Medical Center is testing a new device for people with heart failure. The device is the Cancion CRS system of Orqis Medical Corp. (Lake Forest, Calif.), an extracorporeal, minimally invasive cardiac system, designed to increase blood velocity down the thoracic aorta. As a result, the system is thought to decrease cardic afterload and provide a circulatory boost:

The Cancion CRS therapy seeks to create a "rest-to-recovery" environment for the heart, providing an extracorporeal parallel circuit for improving aortic flow. It provides a continuous circulatory boost - increasing blood velocity and correcting the diminished aortic flow associated with severe heart failure. This minimally invasive therapy accesses only peripheral arteries and never directly connects to the heart, yet initial clinical work demonstrates that the therapy improves renal function, cardiac index and reduces heart failure markers such as BNP.

Patient safety and ease of use were paramount considerations in the design of the Cancion CRS therapy. The arterio-arterial circuit minimizes hemolysis and vessel trauma through the use of sophisticated medical technology. The Cancion system consists of two 12F percutaneous catheters, a sealed bearingless pump and motor, and control system...

By supplementing blood flow in the descending aorta, the CRS therapy is designed to reverse the consequence of abnormal aortic flow, inducing vasodilation and improving renal blood flow. Research data show hemodynamic improvement, reduced ventricular and atrial volumes and improved renal function. Data also indicate that the CRS™ cascade has a sustained effect after removal of the therapy offering the promise for potential therapeutic recovery.

More at Orqis Medical Corp...

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replies: 5 comments
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This is a fantastic invention, but I'm skeptical that there will be "sustained effects" for very long after device removal. My guess is that, as soon as you take it out, you'll have a boggy increase in afterload, decreased renal blood flow leading to a nice creatinine bump, and immediate symptoms of CHF. Sure, maybe it'll take BNP a few days to rise, but that's not really what they're looking at, right? I wouldn't risk putting two indwelling catheters in someone with CHF when pharmacologic therapy is pretty good at this point.

My lab has been working on compact bypass circuits not too dissimilar to this little extracorporeal LVAD type device. LVAD's are excellent as a stopgap measure while waiting for transplant, and they may turn out to be the next pacemaker - long term, implantable devices. Our long term goal, though, is an extracorporeal device for patients with far more advanced disease, one that essentially provides integrated cardiopulmonary bypass and renal dialysis functions.

-joel http://www.c1d1t1.com


Posted by:
on September 22, 2005 08:53 AM GMT

What a fantastic invention... hope it will works as described and without any mistake...


Giochi Scommesse


Posted by: John23
on September 23, 2005 05:53 AM GMT

What a fantastic invention... hope it will work as described and without any mistake...


Giochi Scommesse


Posted by: John23
on September 23, 2005 05:54 AM GMT

I saw some preliminary data presented at a conference nearby and this seems promising. They presented anecdotal information that some patients responded favorably for much longer than the device was working - maybe months. It's not really an LVAD though - apparently there's no direct cardiac link - and the flows they describe are not sufficient to function as an LVAD.


Posted by: tecanfie
on September 27, 2005 08:26 AM GMT

I was wondering if anyone knew where to contact patients that are or have used this device. My father has been asked to participate and I haven't found any info. on how previous studies have been. Please email me as soon as possible at we5go@aol.com
thanks so much.


Posted by: Carol DeAngelo
on November 12, 2005 08:48 AM GMT