Archives: 3/2011

ryt2fwzx 115 Year Old X ray Machine Brought Back to LifeWeeks after Wilhelm Conrad Röntgen published about the development of his X-ray machine, a physicist and a hospital director in Maastricht, The Netherlands, built their own version of the device. Recently, this 115 year old machine was taken out of deep storage, dusted off, and made to work again.
Wired science reports:

Aside from a modern car battery and some wires, the researchers used only the original equipment, including an iron cylinder wrapped in wire to transfer electrical energy from one circuit to another and a glass bulb with metal electrodes at each end.
The glass bulb, technically called a Crookes tube, contained a tiny bit of air, about a millionth of normal air pressure. When the researchers placed a high voltage over the tube, the electrons in the gas were ripped from their atoms and zipped across the tube from one electrode to the other.
Electrons naturally emit X-rays when they speed up, slow down or change direction. When the electrons hit the glass walls of the Crookes tube, they came to a screeching halt, giving off a ghostly green glow and invisible X-rays.


Read on at Wired…
(hat tip: Scope blog)

fldvbt2p Haptic Technology Teaches Blind Kids How to WriteStephen Brewster, professor of human-computer interaction at University of Glasgow, has been testing a haptic system he developed to teach blind kids how to write. The system focuses around the popular Phantom Omni force feedback device from Sensable to help guide the pen in the right direction.

Recently, and in collaboration with the University of Auckland, he has been piloting the device in schools in Auckland. ‘We have worked with pretty much every blind student under 16 years in the whole of Auckland and it seems to work surprisingly well,’ Professor Brewster says. ‘The device can guide or constrain certain types of movements, so as the teacher draws on a touch screen the movements are echoed directly back to the student, allowing the student to feel the movements and learn the letter shapes.’
Professor Brewster’s research has implications not only for visually impaired people.
He is working on technology that he hopes will help us all experience the world in a different way. ‘My research is in multi-modal interaction, which is all about combining the different senses to use computers or access information, the idea being that the more ways of interacting that you can provide, the richer the data. If your eyes are already busy, for example when you’re using a mobile phone to text and you’re walking down the street, why not use some of your other senses instead of getting run over?’

Link: Writing with feeling…

fxw1m82k Learn Anatomy Just Like in Med School With Aspects of Anatomy iPhone AppWarwick Medical School has released an iPhone app of lectures by Dr Peter Abrahams that teaches clinical anatomy to anyone willing to spend £5.

The new app, entitled Aspects of Anatomy, provides 38 short teaching videos using real, plastinated prosections of the lungs, thorax and the arm, from shoulder to hand. You can watch how the professor teaches and demonstrates the function of nerves, tiny twig-like bronchioles or heart valves which very effectively bring medical theory to life. Students can even check progress on their learning by completing the short spot check tests also part of the app.


A sample lesson:

iTunes download link…
More: Anatomy app for medical students on the move…

ks6of3o3 Medtronic Announces Global Launch of Contour 3D Tricuspid RingMedtronic, having received FDA and EU approval, has announced the global launch of the Contour 3D Ring for treatment of tricuspid regurg. Surgeons will be able to select the size and shape of the ring to suit the patient’s anatomy around the valve, ideally leading to less stress on the valve and resulting in better outcomes.

Tricuspid dilation is a progressive disease that eventually leads to severe tricuspid regurgitation (TR), which occurs when the tricuspid valve leaflets do not close properly, allowing blood to flow opposite of the intended direction. For patients with significant dilation of the tricuspid annulus (or opening), surgeons typically recommend surgical repair with an annuloplasty ring or band to restore the normal annular dimensions and normal leaflet closure, and to provide the necessary long-term support of the native annulus.
The Contour 3D Annuloplasty Ring – an extension of Medtronic’s remodeling contoured mitral annuloplasty ring (Profile 3D®) technology – is the only remodeling ring that matches the shape of a healthy tricuspid valve, as determined through computed tomography (CT) images from normal tricuspid valves. The Contour 3D Ring also was designed to avoid interference with the heart’s conduction system and to ensure that valve leaflets open and close effectively while preventing regurgitation.

Press release: Medtronic Announces Global Launch of New Heart Valve Repair Ring Designed to Adapt to Heart’s Natural Valve…

bns57fg Medtronic Announces Availability of Its Activa SC Deep Brain StimulatorAdding to its Activa line of deep brain stimulation (DBS) devices, Medtronic has announced the US and European launch of its new Activa SC DBS system. The new implant is a single-channel neurostimulator used to treat the symptoms of Parkinson’s disease, essential tremor, and dystonia.
From the press release:

The Activa SC system is comprised of an implantable neurostimulator; a thin, insulated lead that is placed in a specific target within the brain; and an extension to connect the neurostimulator and the lead. Like Activa PC, Activa SC is powered by a primary cell (non-rechargeable) battery that does not require maintenance from the patient to provide continuous stimulation for multiple years. An external physician programmer is used to non-invasively adjust stimulation programming parameters, and a hand-held patient programmer with an LCD screen is used by the patient to modify pre-set stimulation settings or check the battery status. Activa SC, like all Medtronic DBS devices, is approved for MRI scans under specified conditions.

Press release: Medtronic Announces Launch of Activa® SC Deep Brain Stimulation System…
Product page: Activa SC Neurostimulator…

cxknham6 New Blood Glucose Test Sensor Uses Tear FluidFor those who suffer from diabetes, the pain that comes with pricking one’s finger often discourages consistent blood glucose monitoring. However, with a new sensor from engineers at Arizona State University and Mayo Clinic, the days of painful finger pricks may be numbered.
Most diabetics probably won’t shed a tear over such news, but perhaps they should, because lacrimation is exactly the basis of this new blood glucose sensor. With the device, a quick and painless dab in the corner of your eye is all it takes to get a sample of tear fluid. The sensor will measure the amount of glucose in the tear sample, which correlates closely with the amount of glucose in the blood.
While the device has numerous challenges ahead, such as obtaining reproducible results, proof-of-concept has been demonstrated and the project has received backing from Mayo Clinic and BioAccel, an Arizona biomedical commercialization non-profit.
Image: Screen-printed electrical leads (A), an insulating layer (B), a silicone fluidics piece (C), a sensing well covering the three electrode system (D), and an absorbent sampling material (E).
Article from ASU: ASU, Mayo Clinic team work to help diabetes patients…
More information from Dr. Jeffrey LaBelle, ASU bioengineer and designer of the device…
Abstract in Journal of Diabetes Science and Technology: A Disposable Tear Glucose Biosensor — Part 1: Design and Concept Testing

Syracuse gold nano Researchers Use Gold Nanoparticles as Drug Carrier in New Cancer Treatment
While we’ve covered a number of cancer treatments which utilize gold nanoparticles, previous methods typically required the use of infrared or near-infrared light to burn the tumors. Now, a team of researchers at Syracuse University has developed a treatment which uses gold nanoparticles as a drug carrier, eliminating the need to burn away any cancerous tissue. The researchers accomplished this by using DNA to attach chemotherapy agent doxorubicin (DOX) to the nanoparticles, which then accumulate at the tumor site due to their high affinity for cancerous tissue.
From the announcement:

A key element of the new system is that the DNA attached to the gold particles is engineered specifically to bind to the DOX anti-tumor drug. Studies show that the DOX can be transferred by diffusion to a receptor DNA molecule.
The gold nanoparticles have an average diameter of only 15.5 nanometers or a few billionths of a meter. A single nanoparticle presents more than 100 DOX sites, and that, when multiplied by millions of the particles, could create a massive and deadly assault on a tumor.
A key advantage of the new system is that the DOX anti-tumor drug is already accepted by the FDA. Other such drugs may be deployed using this system simply by engineering the DNA to bind to a different drug molecule.

Press release: New Drug Delivery System to Improve Cancer Treatment…
Flashbacks: Gold Nanoparticles Recruited to Destroy Difficult to Reach Tumors; Gold Nanoparticles Help in Fighting Skin Cancer

DigInfo TV attended the Cybernics International Forum in Tokyo last week (before the quake) and has profiled the latest that Cyberdyne, a Japanese maker of power assisted exoskeletons, is working on.


Flashbacks: Cyberdyne, Developers of Terminator, Show Off Robotic Legs at Consumer Electronics Show; HAL, The One That Walks, Goes on Sale
(hat tip: Engadget)

v4p3qfys Cevira, A Medical Device/Drug Combination, Proving Itself Against HPV
Cevira, a photodynamic therapy device and hexaminolevulinate ointment combination product from Photocure (Oslo, Norway), is moving right along Phase II clinical trials for the treatment of Human Papilloma Virus (HPV). The package is inserted into a woman’s cervix where it stays active for an entire day, applying both light and ointment to the affected tissue. The device, which was developed with help from Sagentia (Cambridge, Massachusetts), has received FDA approval to continue with Phase II trials.
nv0qa3iu Cevira, A Medical Device/Drug Combination, Proving Itself Against HPV

The Cevira device contains a LED light source that in combination with a medicinal product initiates a photochemical reaction in exposed tissue. The fully integrated single-use device is easily administered by a trained gynaecologist or colposcopist and is then left in place on the cervix up to 24 hours, during which time the patient is able to leave the hospital and continue with her daily activities, before removing and disposing of the device herself.
The clinical trials will investigate this advanced form of photodynamic therapy in patients with cervical precancer as an alternative to current surgical procedures, such as laser therapy, surgical conisation, LEEP excision or cryotherapy (freezing). These can damage healthy tissue and cause long term health issues including post-surgical infections, reduced fertility and an impeded ability to carry a child full-term. The study will also investigate the suitability in treating patients with mild cervical abnormalities, as this new approach could be an alternative to the numerous and stressful follow-up examinations patients currently have to endure.

Photocure Technology …
Link: Breakthrough light activated drug-device to be investigated for treatment of HPV and cervical pre-cancer…