Archives: 11/2010

chip on a pill Novartis Pill Microchip Enables Remote Monitoring of Drug Dosage and Efficacy
Novartis AG, using technology licensed from Proteus Biomedical, is currently developing the Ingestible Event Marker (IEM), a specialized microchip which the company plans to add to pills. When a patient ingests an IEM-enhanced pill, their stomach acids activate the microchip, which then sends data such as heart rate, temperature, and body movements to a dermal patch via Bluetooth connectivity. This patch can then export the data to an EMR, so that it can be accessed by the patient’s doctors. Novartis claims that because their device will not alter the effects of the drugs it is paired with, they could bring the IEM to market in as little as two years.
More from Reuters:

The initial program will use one of the Swiss firm’s established drugs taken by transplant patients to avoid organ rejection. But Trevor Mundel, global head of development, believes the concept can be applied to many other pills.
“We are taking forward this transplant drug with a chip and we hope within the next 18 months to have something that we will be able to submit to the regulators, at least in Europe,” Mundel told the Reuters Health Summit in New York.
“I see the promise as going much beyond that,” he added.

Full story: Look out, your medicine is watching you …
Proteus Biomedical…
Flashbacks: Proteus’ Wireless Personal Health Monitor Receives 510(k) Clearance; Chip-on-a-Pill, and Other Micro-Electro-Medical Devices; Proteus Pill Ingestion Monitoring System Gets EU Green Light; A Quick Look at The Status of Smart Pill Technology; Microchipped BP Pills Remind Patients to Take Their Meds

viwiedj Portable Wireless Fetal Heartbeat and Uterine Contractions MonitorThe West Wireless Health Institute has unveiled its new portable cardiotocography (electronic fetal monitoring) system. The device, which communicates either over cellular or a WIFI connection, should allow a physician to monitor fetal heartbeat and uterine contractions remotely.

“Maternal mortality remains a persistent and preventable global health challenge in many parts of the world,” said Don Casey, WWHI’s CEO. “The Institute recognizes the need and the opportunity to address this challenge with a uniquely engineered solution that leverages low-cost technologies. The ability to monitor both maternal and fetal wellbeing – at home, at work, wherever a patient may be during the course of the day – creates a far more complete picture of their condition. Ultimately, we want to help this population stay healthy and avert a preventable crisis.”
Women with high-risk pregnancies require monitoring several times each week during the last months of pregnancy, and must often alter job and family responsibilities for repeated visits to a provider. In many areas of the world, the burden is exacerbated by long distances to the nearest clinical facility. Sense4BabyTM is designed to create ease and convenience for the patient, while improving the provider’s ability to access data anywhere the patient resides.

Press release: West Wireless Health Institute Announces Development of Its First Engineering Prototype…
Image credit: Steve O’Toole

83kdjjj Radiology Joystick for a More Natural Image Viewing
Professor David Lomas of the Department of Radiology at the University of Cambridge and Dr Martin Graves of Cambridge University Hospitals NHS Foundation Trust have developed a new 3D joystick for browsing volumetric computer tomography images. The inspiration came from the way ultrasound transducers are operated by gliding it around the target area. See for yourself in this video:


Press release: Taking control of medical imaging …
Project description: Controller For Navigating 3D Medical Imaging Data

83kdkjj Laptop Use Causes Scrotal HyperthermiaMale readers be advised! Using your laptop placed on your knees to read this post may cause your testicles to heat up quite significantly. However surprisingly, this is not due to the heat dissipated by many laptops, but rather due to the positioning of the legs. A study just published online in the journal Fertility and Sterility investigated ways to avoid the testicles from overheating while using a laptop computer. Right and left scrotal temperature were measured in 29 volunteers while working on the laptop in different positions: with closely approximated legs; with closely approximated legs with a lap pad below the laptop; and sitting with legs apart at a 70° angle with a lap pad below the laptop. After 60 minutes, with closed legs, temperature increased about 2.4 degrees Celsius, using the lap pad yielded a slightly smaller increase of 2.1 degrees, while spreading the legs resulted in a modest increase of 1.4 degrees. The authors conclude that prevention of scrotal hyperthermia in laptop users is not feasible, although we would like to disagree and suggest using a flat surface, such as a table or desk, to position your laptop in order to preserve your fertility.
Article abstract: Protection from scrotal hyperthermia in laptop computer users…
Image credit:
Pitel…

90gv3jj4 MEDI PORT Offers Comprehensive Clinical TeleconferencingC PORT Solutions out of Atlanta, Georgia has released a new teleconferencing system for clinical collaboration. The system provides video, audio, white board capabilities and everything is integrated with electronic medical records for looking up and sharing not just what’s going on in the current procedure, but also the history of the patient.

The device allows remote medical specialists to view patients and provide expert counsel, especially important for rural clinics and field hospitals with limited medical staff. Live surgeries can be shared remotely for purposes of mentoring and training and better diagnoses are enabled via bedside access to patient data and web based resources.
C PORT, in collaboration with St. Joseph’s, has configured Rubbermaid Medical Solutions’ industry leading medical cart with C PORT’s platform to converge high definition video conferencing, high definition audio conferencing, web conferencing and interactive annotation/white board technology onto a single mobile device that can be rolled anywhere, including a patient or procedure room. Rubbermaid Medical Solutions is the leading provider of clinical workstations and mobile computing solutions for healthcare facilities.
MEDI PORT is simple to use and delivers significantly more functionality at half the cost of other medical carts enabled with video conferencing capabilities.

Press release: C PORT Solutions Launches MEDI PORT to Bring Powerful New Telemedicine Solutions to the Hospital Bedside…

32532aqrt HemaCam Performs Blood Counts Automatically
German firm Horn Imaging GmbH and Fraunhofer Institute for Integrated Circuits have jointly developed a new automated complete blood count (CBC) system that can perform quick and accurate counting of leukocytes and other cells from blood smears. The system will be presented at the upcoming Medica 2010 in Düsseldorf, and here’s what the system can do:

Advantages in analysis:
•Quick and reliable counting of blood smears
•Microscopic live view of cells
•Annotate and mark cells
•Intelligent database, customizable to theclassification of the respective laboratory
•Digital storage of all relevant data
•Future-proof modular system
Advantages at work:
•Support for the standardization and quality assurance process in clinical hematology
•Safe diagnosis support based on objective and reproducible classification proposals
•Cell counts and classification proposals are saved in a database and can be reproduced and called up at any time
•Short adaption cycles based on intuitive user interfaces
•Also ideal for purposes of continuing education

Product page: HemaCAM …
Full story: Performing blood counts automatically …
Project page at Fraunhofer: HemaCAM …

43534aqop Glucose Responsive Polymer Offers Hope to DiabeticsInvestigators at Leicester School of Pharmacy at De Montfort University in the UK are working on a new in vivo closed-loop insulin delivery technology. At the heart of the project is a covalently bonded glucose-responsive gel material, polymerized from dextran and concanavalin A, and modified with acrylic side groups. The interesting property of this polymer is its ability to undergo a viscoelastic transformation in the presence of free glucose. So, the material, when impregnated with insulin, can be made to release controlled doses of the hormone in response to blood glucose levels. Dr. Joan Taylor and colleagues at De Montfort are already working on an implantable device that uses this patented gel that might eliminate the need for daily insulin injections. For now, everything is on paper and in the lab, so we will have to follow this group’s efforts in the future to see what pans out of this project.
Abstracts: Glucose-responsive UV polymerised dextran-concanavalin A acrylic derivatised mixtures for closed-loop insulin delivery Biomaterials Volume 27, Issue 8, March 2006, Pages 1586-1597;
UV Cross-Linked Dextran Methacrylate–Concanavalin A Methacrylamide Gel Materials for Self-Regulated Insulin Delivery Drug Development and Industrial Pharmacy 2008, Vol. 34, No. 1 : Pages 73-82
More: Diabetes Expert Develops Artificial Pancreas…

83sjjjd SpeedFix Suture Anchor System Gets Green Light in USArthroCare Corp. out of Austin, Texas has received FDA marketing approval for the SpeedFix Suture Anchor system.

SpeedFix, a push-in anchor made of PEEK (polyether-etherketone) polymer, is designed for the repair of certain tears of the labrum in a shoulder.
SpeedFix anchors, which are double-loaded with ArthroCare’s high-strength MagnumWire(R) suture, provide surgeons with independent bone locking, suture tensioning and suture locking to ensure tissues are securely attached to the glenoid.

Press release: ArthroCare Receives FDA Clearance for SpeedFix …

eiickkk Under Development: Cavopulmonary Impeller Pump for Fontan Circulation
Children born with univentricular hearts typically have to undergo a multi-staged Fontan repair to fix the defect. Usually, the first stage is a creation of a bidirectional Glenn shunt, and the second stage is Fontan completion. (To learn more about the Fontan, check this Wikipedia entry.) Survival rates are still low, but researchers at Purdue University have created a tiny heart pump that should help the heart during the perioperative and postoperative period. The basic problem with Fontan physiology is a univentricular circulation that features systemic venous hypertension and pulmonary arterial hypotension. So, investigators at Purdue thought that they might improve cardiac performance and systemic and pulmonary perfusion by augmenting cavopulmonary circulation, and providing a modest increase in ventricular filling by implanting a so-called von Kármán viscous impeller pump. Such a cavopulmonary pump can raise filling pressures only 2 to 5mmHg, and that in itself can provide the necessary pressure gradient boost to restore circulation to better resemble a normal two-ventricle physiology.
If everything goes according to plan, the percutaneous catheter delivered pump may allow all stages of Fontan to be done in one go, hopefully leading to much better outcomes. It is also hoped that older people with the condition may benefit from having this device implanted for continuous use.
bq3gbg Under Development: Cavopulmonary Impeller Pump for Fontan Circulation

Researchers plan to implant the new pump into a four-way intersection where the inferior and superior vena cavae meet the right and left pulmonary arteries. Once inserted with a catheter, the pump can be dramatically expanded, forming a shape that resembles two cones joined at the base. The device spins at about 10,000 rpm, connected via a slender cable to a small motor outside of the body.
Frankel [Steven Frankel, Purdue University professor of mechanical engineering] and graduate student Travis Fisher originated the design, applying concepts from textbook fluid dynamics developed a century ago by Hungarian engineer Theodore von Kármán, founder of modern aerodynamics.
The researchers also found design inspiration from an unlikely source: cocktail umbrellas.
"A major challenge was, how do we get this into the body, and we thought of the cocktail umbrella," Frankel said. "It starts out flat and compact and then opens out with a similar shape, with upper and lower segments."
The rotating device contains riblike grooves to efficiently pump blood. The design is promising because testing has shown that the rotating device causes minimal damage to red blood cells.
“Because it’s larger than other experimental pumps, it doesn’t have to spin as fast – a maximum of about 10,000 rpm compared to 50,000 for another experimental pump – so it causes less damage to blood cells,” Frankel said. “It’s like the gentle cycle in a washing machine.”
Experiments at the University of Louisville that mimic the circulatory system show the degree of damage done to blood cells by the spinning pump is acceptable for clinical use.

Press statement from Purdue: New heart pump to provide temporary assist for infants, adults …
Article in Journal of Thoracic and Cardiovascular Surgery: Cavopulmonary assist for the univentricular Fontan circulation: von Kármán viscous impeller pump