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TEDMED kicks off in two weeks (October 26th to 29th) and we’re excited to let you know that we’ll be there throughout, providing detailed coverage. We think it’s one of the best events out there for us to both discover and showcase groundbreaking innovations in medicine, and we’re going to work hard to make you feel like you’re there too. Though oh course, we think we’ll have a little fun along the way. Remember last year’s interviews with Steve Wozniak and Patch Adams?
This year’s line up of speakers is strong, so take a look at the list and give us input in the comments if there’s someone you’d like us to hunt down for an interview.
Some speakers we’re particularly excited about:
Aneesh Chopra – Chief Technology Officer of the United States Frank Gehry – Architect (we’re curious to see what he has to say about medicine) Bill Moggridge – Director, Cooper-Hewitt, National Design Museum, Smithsonian Institution Anita Goel – Chairman & Scientific Director, NanoBiosym Craig Venter – Founder, Chairman & President, J. Craig Venter Institute
Remember to check Medgadget regularly between October 26th and 29th. Link:TEDMED…
A team of researchers spearheaded by the Salk Institute for Biological Studies has for the first time mapped the connections between photoreceptors in the eye with retinal ganglion cells, neurons that dispatch visual signals to the brain. The study performed on a macaque monkey demystified the code used to relay color information to the brain and revealed “computations in a neural circuit at the elementary resolution of individual neurons.”
One of the essential elements that made the experiments possible was the unique neural recording system developed by an international team of high-energy physicists from the University of California, Santa Cruz; the AGH University of Science and Technology, Krakow, Poland; and the University of Glasgow, UK. This system is able to record simultaneously the tiny electrical signals generated by hundreds of the retinal output neurons that transmit information about the outside visual world to the brain. These recordings are made at high-speed (over ten million samples each second) and with fine spatial detail, sufficient to detect even a locally complete population of the tiny and densely spaced output cells known as “midget” retinal ganglion cells.
Visual processing begins when photons entering the eye strike one or more of the 125 million light-sensitive nerve cells in the retina. This first layer of cells, which are known as rods and cones, converts the information into electrical signals and sends them to an intermediate layer, which in turn relays signals to the 20 or so distinct types of retinal ganglion cells.
The Salk researchers simultaneously recorded hundreds of retinal ganglion cells, and based on density and light response properties, identified five cell types: ON and OFF midget cells, ON and OFF parasol cells, and small bistratified cells, which collectively account for approximately 75 percent of all retinal ganglion cells.
To resolve the fine structure of receptive fields-the small, irregularly shaped windows through which neurons in retina view the world-the authors used stimuli with tenfold smaller pixels.
When combined with information on spectral sensitivities of individual cones, maps of these punctate islands not only allowed the researchers to recreate the full cone mosaic found in the retina, but also to conclude which cone fed information to which retinal ganglion cell.
Chichilnisky [E.J. Chichilnisky, Ph.D., associate professor in the Systems Neurobiology Laboratories] and his team discovered that populations of ON and OFF midget and parasol cells each sampled the complete population of cones sensitive to red or green light, with midget cells sampling these cones in a surprisingly non-random fashion. Only OFF midget cells frequently received strong input from cones sensitive to blue light.
Dean Kamen, someone who holds celebrity status among Medgadget editors, is going to have his own show on the Planet Green channel. Dean of Invention will premiere on Friday, October 22 at 10 Eastern, and it looks like it won’t disappoint. Dean Kamen will be taking viewers to different research institutions where he’ll speak with scientists working on amazing inventions that are in an advanced state of development. Judging by the announced episode lineup, there’s going to be a lot of focus on medical technology. Here are a few previews to get excited:
Philips has introduced a new patient monitor, the IntelliVue MX800, that provides common vital sign data, but that can also display information coming from any other hospital database. The product essentially acts like a bridge that can deliver together patient information from different sources right to the point of care.
From the announcement:
The MX800 also enables applications to run natively on the embedded informatics platform while keeping the real time patient monitoring separate and protected. This allows clinicians to easily view patient data from sources such as electronic medical records (EMRs), imaging studies and other clinical applications, helping to save caregivers’ time and aid in clinical decision making at the point of care.
Designed to facilitate more effective care delivery, the Philips IntelliVue MX800 delivers advanced clinical decision support and workflow applications. With access to a wider range of clinical information, the system presents clinicians with meaningful point of care information that may enable the earliest possible medical intervention. Access to this critical information is essential as healthcare facilities seek new and efficient ways to keep closer track of patients’ status and better manage their care, whether in critical care settings or as patients are stepped down to general wards.
The IntelliVue MX800 is embedded with Philips’ industry-standard informatics platform to deliver more valuable information without making any significant changes to the existing hospital environment. For the clinician, it is based on the familiar, easy to use IntelliVue user interface and applications, and its wide touch screen designed with smooth surfaces and a minimum number of seams, making it easy to clean and reducing the risk of cross-contamination.
Last week Canon previewed its new CR-2 Digital Non-Mydriatic Retinal Camera at the Vision Expo West in Las Vegas. The device can be used with any Canon EOS camera, which means that specs are dependent on what model you go with. The CR-2 still requires FDA approval before it can come to the American market.
The CR-2 Digital Non-Mydriatic Retinal Camera incorporates the latest in Canon retinal imaging technology and enhancements in a compact and lighter design, weighing only 33 pounds. The CR- 2 retinal camera can be easily installed and takes up minimal office space or for added convenience, can be easily transported when needed. The illuminated control panel on the CR-2 retinal camera allows medical staff to navigate operations in darkened rooms. Contributing to a lower total-cost-of-ownership, the CR-2 retinal camera can help reduce energy costs in medical facilities with its energy-efficient design.
The CR-2 Digital Non-Mydriatic Retinal Camera incorporates EOS camera technology to create 15.1-megapixel retinal imaging2. This technology has been specifically adapted to capture extremely detailed diagnostic images of the retina, helping eye care professionals detect and monitor ocular conditions. A single sensor handles all functions for infrared observation, color and digital filtered images for red-free and cobalt imaging.
The CR-2 retinal camera’s low flash intensity minimizes pupil constriction and shortens the time required for taking multiple pictures such as binocular, stereo photography. It also helps avoid having to retake images due to patient’s blinking. The CR-2 retinal camera’s small pupil mode has a 3.3mm diameter that contributes to efficient screening and assists when a patient’s pupil is difficult to dilate. The auto exposure function optimizes image brightness without having to manually set the observation light and flash intensity. The white LED for flash intensity improves maintenance frequency and power consumption, helping to save on operating costs.
While the advantages of robot-assisted surgery are many, these procedures also have a downside which is often overlooked: the surgeon receives no physical feedback while performing a robot-assisted procedure. To remedy this problem, a researcher at the Eindhoven University of Technology in The Netherlands has developed the Surgeon’s Operating Force-feedback Interface Eindhoven (Sofie) robot. Sofie can alter the resistance of the surgical controls based on how much force it is exerting on the patient’s tissues, which will help surgeons keep track of how much pressure they are placing on the patient’s organs.
From Gizmag:
Van den Bedem’s creation is also more compact than most surgical robots, and is mounted on the operating table instead of the floor. This means that when the table is tilted or moved within the room, Sofie will move with it, so no readjustments will be necessary
TU/e has patented the force-feedback system, and van den Bedem is now looking into commercializing Sofie. She anticipates it will be at least five years before the robot is available for purchase.
Synapse Biomedical out of Oberlin, Ohio has received the Humanitarian Use Device (HUD) designation for use of its NeuRx Diaphragm Pacing System on ALS patients with “a stimulatable diaphragm who are experiencing chronic hypoventilation.” The device electrically stimulates the diaphragm to contract and expand, bringing back breathing to some of those that would otherwise be stuck to a ventilator. Two years ago the system was approved by the FDA for people with spinal cord injury and it has approval in Europe for diaphragm dysfunction. The latest FDA designation allows the company to seek a Humanitarian Device Exemption for the NeuRx system.
The NeuRx DPS™ is a four-channel battery-powered external pulse generator (EPG) with electrodes that are implanted through minimally invasive laparoscopic surgery to provide electrical stimulation to the muscle and nerves of the diaphragm, the principal breathing muscle.
During the procedure, a surgeon creates four dime-size holes in the abdominal region and inserts a laparoscope so the diaphragm muscle can be seen. The surgeon then places small electrodes in the diaphragm. The electrodes are attached to the EPG that stimulates and causes a contraction of the diaphragm. The ALS surgery is typically done on an outpatient basis.
Post-operatively, the EPG is programmed and the patients and caregivers are trained on the use of the NeuRx DPS™.
Spectrophotometry is an excellent teaching topic in science classrooms because it can bridge understanding of how different physical phenomena can be studied using one simple technique. But spectrophotometers can be expensive for high school budgets and third world clinical chemists, and the typical closed box design of these devices doesn’t help either. Alexander Scheeline, a chemistry professor at University of Illinois at Urbana-Champaign has developed a cheap and simple kit to convert almost any camera phone into a basic spectrophotometer at a cost of less than $3. And since just about every kid now has a camera phone, a class of 30 students can be outfitted for about $100.
For a light source, Scheeline used a single light-emitting diode (LED) powered by a 3-volt battery, the kind used in key fobs to remotely unlock a car. Diffraction gratings and cuvettes, the small, clear repositories to hold sample solutions, are readily available from scientific supply companies for a few cents each. The entire setup cost less than $3. The limiting factor seemed to be in the light sensor, or photodetector, to capture the spectrum for analysis.
“All of a sudden this light bulb went off in my head: a photodetector that everybody already has! Almost everybody has a cell phone, and almost all phones have a camera,“ Scheeline said. “I realized, if you can get the picture into the computer, it’s only software that keeps you from building a cheap spectrophotometer.”
To remove that obstacle, he wrote a software program to analyze spectra captured in JPEG photo files and made it freely accessible online, along with its source code and instructions to students and teachers for assembling and using the cell-phone spectrometer. It can be accessed through the Analytical Sciences Digital Library.
Last week, we got a chance to visit the Brooke Army Medical Center (BAMC, pronounced “bam see”), located in San Antonio, Texas. BAMC is one of the U.S. military’s primary hospitals and a major medical research facility: the 450-bed hospital features a level-one trauma center, graduate medical education, and military’s only American Burn Association-verified Burn Center. The ABA verification means that all burn victims from Iraq and Afghanistan arrive at BAMC, after a stopover in Landstuhl, Germany, about two days after the injury on the battlefield. The hospital-based U.S. Army Institute of Surgical Research (USAISR) Burn Flight Team has transported to the hospital hundreds of casualties using specially modified C-17 transport planes. Once on site, patients receive full-time physical and mental therapy, while clinical researchers have a lab-to-animal-to-clinical-trial facility to improve the care provided. Although it is a Department of Defense facility, the hospital accepts civilian patients from the surrounding region, and the research scientists publish in clinical journals and share their knowledge with the world.
Burns to the face create a special treatment challenge because applying pressure with a bandage, like in the cases of burns to torso or limbs, is impossible. In order to make individualized plastic masks that perfectly fit the patient, the center has built its own system to digitize the face in 3D, mill a mold, and press the plastic into shape.
Here’s our editor Gene Ostrovsky’s face being laser-scanned, just like a new patient:
Once the scan is complete, a technician cleans up the 3D model, smoothes it out, and sends it to the mill where a special hard foam is used to make the mold:
Once the mold is complete, it is sent to a vacuum forming machine that produces the final product – simply clip on some straps you’ve got a perfectly fitting mask in a matter of three hours.
The burn center also has a SnowWorld virtual reality video game system, that we reported on a few years ago, for patients to play during bandage changes. The system was developed at the University of Washington, and a clinical study at BAMC have shown a significant reduction in perceived pain while playing in the snowy, cold world. Here’s a link to a short NPR report about the use of SnowWorld at BAMC.
Other interesting research going on at the Institute of Surgical Research includes the use of ketamine for PTSD patients, stem cell therapies, regenerative medicine, and a blood coagulation research program. A lot of the research is done for conditions often ignored by the private industry, like severe trauma care, malaria, and Japanese Encephalitis. Here the researchers are also involved in battlefield clinical trials for such things as tourniquets and new gauze material. We also saw a Nintendo Wii being used for rehab sessions. Even though there’s a considerable amount of research being done already, the institute will soon double in size. The new building is already built and equipment is starting to flow in, generating a lot of excitement from the current staff who will get a lot more space, and thanks to the design, a lot more sunlight in their labs and offices. Here’s an animation of the new facility…
The clinicians referenced the strong attention that evidence-based medicine is given, the great interest in technology that “the command” has in improving care, and a singular focus of the entire place on the quality of life of the wounded.
For longer-term rehabilitation of wounded warriors, right nearby there’s the Center for the Intrepid, a three year old facility built purely with donated money. The Center has climbing walls, a surfing pool, all kinds of rehabilitation technology, and lots of virtual reality video games to make a difficult recovery considerably more fun and productive. Sadly, we didn’t get a chance to visit the center due to the tight schedule.
As for preparedness training, battlefield doctors and nurses learn from experience by setting up a field hospital in the local woods nearby and actually taking in real patients who don’t mind an unusual clinical setting. Medics that expect to be rescuing casualties from the battlefield even get training in a cadaver lab to help prepare for the shock of seeing terribly injured and fatally wounded people. Because this is a military hospital, there’s very little paperwork to deal with regarding payment and insurance, something the doctors and nurses were really excited about. There’s also a fully implemented EMR system and nutritionists, for example, use it to program patient diets so that heart patients don’t get a BLT for breakfast. The facility also has an InTouch robot, camouflaged of course, for remote consultations with specialists in other hospitals.
The Army doctors and nurses we were with spoke a lot about constant forced career progression, training outside the military, and new mentors and leaders to work with. We spoke with folks that started their careers launching mortars during Desert Storm and are now providing advanced nursing care to the severely injured. One interesting thing we noticed is how close civilians and contractors work together with the uniformed team members. However, the uniformed were proud of the elite training they receive, the ability to perform their work in limited resource, dangerous environments, and a real mission that motivates everyone to succeed.
The Army was kind enough to sponsor the transportation and lodging for this one day visit, and we’d like to truly thank them for this opportunity and for the work they do in treating our wounded heroes.