Archives: 8/2010

Engineers at Saitama University’s Human-Robot Interaction Center in Saitama, Japan have created a wheelchair movement system that keeps it always next to a walking person wearing a radio beacon. The wheelchair is smart enough to realize both its position and orientation relative to the person guiding it and realizes when its best to follow behind rather than on the side in tight and congested areas. Undoubtedly this is a big deal for people with disabilities for whom controlling the wheelchair is in itself a challenge. Judging by the video below, which demonstrates the wheelchair in a public area, it looks like it’s just about ready for commercial production.


More at DigInfo TV…
(hat tip: Engadget)

8xv0l27m Fenwal Gets New 510(k) Clearance That Could Increase Plasma SupplyFenwal, Inc. (Lake Zurich, Illinois) has announced 510(k) clearance for use of the company’s Amicus separator with the new InterSol platelet additive. InterSol can take the place of plasma, which is currently used as a storage medium for platelets collected from donated blood. This frees up additional plasma for hospital use without requiring an increase in blood donations.
From the press release:

While practices vary at blood centers, healthy donors may donate platelets as often as once a week, but no more than 24 times in a 12-month period. In granting the new 510(k) clearance, the FDA has approved an addition to Fenwal labeling that defines specific conditions under which the volume of plasma replaced by InterSol® solution may be collected without increasing the donor deferral period.

Press release: FDA Grants Fenwal New 510(k) Clearance…
Product page: AMICUS® Separator…

ry2xtzs3 Technique Images Magnets Using High Precision FMRResearchers from Ohio State University just published a paper in Nature describing a new MRI technique that is capable of imaging the insides of micro-scale magnets, providing the highest ever resolution of magnetic fields. The technology, known as scanned probe ferromagnetic resonance imaging, promises the development of small scale biosensors that depend on tiny magnets to do their work.
From the article abstract:

Conventional ferromagnetic resonance (FMR) provides quantitative information about ferromagnetic materials and interacting multicomponent magnetic structures with spectroscopic precision and can distinguish components of complex bulk samples through their distinctive spectroscopic features. However, it lacks the sensitivity to probe nanoscale volumes and has no imaging capabilities. Here we demonstrate FMR imaging through spin-wave localization. Although the strong interactions in a ferromagnet favour the excitation of extended collective modes, we show that the intense, spatially confined magnetic field of the micromagnetic probe tip used in FMR force microscopy can be used to localize the FMR mode immediately beneath the probe. We demonstrate FMR modes localized within volumes having 200 nm lateral dimensions, and improvements of the approach may allow these dimensions to be decreased to tens of nanometres. Our study shows that this approach is capable of providing the microscopic detail required for the characterization of ferromagnets used in fields ranging from spintronics to biomagnetism. This method is applicable to buried and surface magnets, and, being a resonance technique, measures local internal fields and other magnetic properties with spectroscopic precision.

Abstract in Nature: Nanoscale scanning probe ferromagnetic resonance imaging using localized modes…
Press release: Scientists achieve highest-resolution MRI of a magnet…

659cb7bvs Injecting Chemical Bubbles into Live CellsIntroducing chemicals for research and therapeutic uses into individual cells can be tricky using microscopic needles, so researchers at Nanyang Technological University in Singapore have developed a method of shooting ultra-precise jets of liquid straight through the membrane. The method does not seem to damage the function of living cells.

The physicists produced the jets by focusing lasers into a fluid surrounding a target cell. The lasers heated molecules of a blue dye dissolved in the fluid, which in turn created tiny bubbles to rapidly grow and collapse. When these sorts of bubbles are produced individually, they create shock waves that spread throughout the liquid. But producing two adjacent bubbles in rapid succession results in small, powerful jets capable of poking tiny holes, measuring only 0.2 millionths of a meter across, in cell membranes.
The researchers confirmed that the jets allowed the introduction of fluids into the cell by checking for signs of the blue dye inside the pierced cells. The dye is toxic, and it killed the pierced cells, but the holes the jets produced were small enough that it’s likely that the jets will offer a way to inject live cells with nontoxic substances without significantly damaging them.


Article in Physical Review Letters: Aiming with bubbles…
APS press release: Single cell injections…

6je17712 Nanosensors Detect Cancer Biomarkers In Exhaled BreathResearchers at Technion – Israel Institute of Technology have shown that nanosensors can be effective in detecting certain types of cancer in exhaled breath. Pending further studies, it is hoped that this technology will be used for regular screening of patients as part of doctors’ appointments.

Exhaled alveolar breath was collected from 177 volunteers aged 20–75 years (patients with lung, colon, breast, and prostate cancers and healthy controls). Breath from cancerous subjects was collected before any treatment. The healthy population was healthy according to subjective patient’s data. The breath of volunteers was examined by a tailor-made array of cross-reactive nanosensors based on organically functionalised gold nanoparticles and gas chromatography linked to the mass spectrometry technique (GC-MS).
The results showed that the nanosensor array could differentiate between ‘healthy’ and ‘cancerous’ breath, and, furthermore, between the breath of patients having different cancer types. Moreover, the nanosensor array could distinguish between the breath patterns of different cancers in the same statistical analysis, irrespective of age, gender, lifestyle, and other confounding factors. The GC-MS results showed that each cancer could have a unique pattern of VOCs, when compared with healthy states, but not when compared with other cancer types.
The reported results could lead to the development of an inexpensive, easy-to-use, portable, non-invasive tool that overcomes many of the deficiencies associated with the currently available diagnostic methods for cancer.

Link: Breath test could help to detect cancer…
Abstract in British Journal of Cancer: Detection of lung, breast, colorectal, and prostate cancers from exhaled breath using a single array of nanosensors
Image credit: Fernando de Sousa

rvj8epxf Photoacoustic Imaging of Melanoma Using Gold NanocagesResearchers at Washington University in St. Louis have developed a new imaging technique for melanoma. For melanoma resection it is very important to obtain tumor free margins in order to prevent recurrence. Photoacoustic imaging works by absorption of light by tissue which causes slight heating (a matter of millikelvins) and with that thermoelastic expansion. By using pulsed light, an acoustic signal can be generated using this effect. Photoacoustic tomography detects structures that strongly absorb light such as melanomas which contain melanin. However even melanoma images are still fuzzy using only this method, so the researchers decided to use gold nanocages as a contrast agent. Using nanocages bioconjugated with a certain type of melanocyte-stimulating hormone, they were able to capture high-resolution photoacoustic tomography images where margins are clearly visible. Potential applications of this technique include detection of early stage melanomas and metastatic lymph nodes, treatment using photothermal effects and image-guided surgical resection. Here’s a short video showing the obtained images:


Press release: Seeing melanoma…
Article abstract: In Vivo Molecular Photoacoustic Tomography of Melanomas Targeted by Bioconjugated Gold Nanocages…

988yr439 InSpace Biodegradable Balloon for Rotator Cuffs Gets EU Clearance
According to Israeli business newspaper Globes, a local company called OrthoSpace Ltd. has obtained CE Mark of approval for its product, the InSpace balloon, which is designed to be a temporary bursa-like padding for patients suffering from rotator cuff tears.
A spokesperson for the company tells us the following about the device:

Massive Rotator cuff tears present both a physical and biological challenge to the surgeon attempting to repair them. The tear is considered irreparable according to pre-procedural MRI imaging or intra-operative assessment. The cuff tissue is often retracted and degenerated. The muscle tissue can be atrophied and with fat infiltratation.
While the average rate of rotator cuff re-tear post repair is approximately 20-40%, failure rates of massive tears can approach 100%. Surgeons are looking for a solution which will reduce significantly their patient pain.
By having the Biodegradable InSpace™ Balloon implanted between the acromion and the humeral head, a space is created between the bone structures; allowing for smooth and frictionless gliding. The InSpace™
Balloon demonstrated successfully pain reduction and ROM improvement, with very high safety profile.
The Balloon was initially designed for chronic, massive, non-reparable rotator-cuff tears; enabling leverage of other muscles. The Balloon may be inserted arthroscopically, or with a mini-open procedure.
The InSpace™ Balloon surgical technique is only five steps of fast and elegant procedure, which has the potential for a quick rehabilitation program.

Globes: Orthospace obtains CE Mark for shoulder balloon implant…
Company page: OrthoSpace …

rad4zzws Porcine Pericardium Patch Passes Permit PhaseKind of a cheat there with that last word, but the dCell Vascular Patch made by Tissue Regenix (York, UK) has received CE mark approval for sales in Europe.

The dCELL® Vascular Patch is a sterile, non-cellular biological scaffold manufactured to the highest quality and safety standards from porcine pericardium which is intended to be permanently implanted into the human body for vascular repair.

This product, and products like it, takes biological material from animals (pigs in this case) and through various processes strips out the material the human body would mount an immunological attack against while leaving the underlying structure, allowing grafts of things like heart valves without requiring immuno-suppresive drugs.
Full press release: Tissue Regenix receives approval to commence sales of its lead product the dCELL® Vascular Patch…
Product site: dCell Vascular Patch…

q3hh34 Research Suggests Autism Could be Diagnosed With a 15 Minute Brain ScanA team of researchers at King’s College London has developed a brain scan which can purportedly detect autism in adults. The scan, which uses MRI to obtain images of the brain, can identify autism based on the physical makeup of grey matter in the brain. Results of an initial study involving the scan were published in the Journal of Neuroscience today.

The team used an MRI scanner to take pictures of the brain’s grey matter. A separate imaging technique was then used to reconstruct these scans into 3D images that could be assessed for structure, shape and thickness – all intricate measurements that reveal Autism Spectrum Disorder (ASD) at its root.
The research studied 20 healthy adults, 20 adults with ASD, and 19 adults with ADHD. All participants were males aged between 20 and 68 years. After first being diagnosed by traditional methods (an IQ test, psychiatric interview, physical examination and blood test), scientists used the newly-developed brain scanning technique as a comparison. The brain scan was highly effective in identifying individuals with autism and may therefore provide a rapid diagnostic instrument, using biological signposts, to detect autism in the future.

KCL’s press release: Adult autism diagnosis by brain scan…
Abstract in The Journal of Neuroscience: Describing the Brain in Autism in Five Dimensions – Magnetic Resonance Imaging-Assisted Diagnosis of Autism Spectrum Disorder Using a Multiparameter Classification Approach