Archives: 1/2010

6345gga Protectan Technology May Lead to Drugs That Mitigate Effects of Radiation Exposure
Cleveland Biolabs, a company out of St. Buffalo, NY, has received the first US patent for technology to make drugs to treat radiation exposure in mammals. The Protectan system utilizes flagellin protein to mess with the mechanisms of apoptotic cell death, specifically focusing on how those mechanisms differ between normal and tumor cells.

CBLB502 is a derivative of a microbial protein, which has demonstrated the capacity to reduce injury from acute stresses, such as radiation in animal models. CBLB502 mobilizes several cell protective mechanisms, including inhibition of programmed cell death (apoptosis), reduction of oxidative damage and induction of regeneration-promoting cytokines.
CBLB502 is being developed under the U.S. Food and Drug Administration’s Animal Efficacy Rule to treat Acute Radiation Syndrome (ARS) or radiation poisoning from any exposure to radiation such as a nuclear or radiological weapon/ dirty bomb, or from a nuclear accident. This approval pathway requires demonstration of efficacy in representative animal models and safety and drug metabolism testing in healthy human volunteers.
Evidence of CBLB502′s mechanism of action and activity in animal models was published in Science Magazine in April 2008 (Science, 2008, vol. 320, pp. 226-230). Data from 50 subjects in an initial Phase I safety and tolerability study indicated that CBLB502 was well tolerated and that normalized biomarker results corresponded to previously demonstrated activity in animal models of ARS. There is currently no FDA approved medical countermeasure to treat ARS.
CBLB502 is also being developed as a supportive care measure to reduce and prevent occurrence of side effects of radiotherapy or chemotherapy in cancer treatment.

Cleveland BioLabs technology backgrounder…
Press release: Cleveland BioLabs Receives First U.S. Patent for Radiation Protection Drug CBLB502…
US Patent 7,638,485: Modulating apoptosis

Art

98234n Medicine and Art: Imagining a Future for Life and Love
The Mori Art Museum in Tokyo, Japan is currently hosting an exhibition that highlights the intersection of art and medicine, and the role of the human body in bringing those two intellectual worlds together. Though the collection mainly consists of historical objects, many from the distant past, the aim of the curators is to draw attention to how medical technology will impact our lives in the future.
55234nnsd Medicine and Art: Imagining a Future for Life and Love

For most human beings their own body represents both the most familiar and most unknown of worlds. From ancient times humans have sought to unravel the secret mechanisms of the body, developing in the process a wealth of medical expertise. At the same time we have seen our own bodies as vessels for the representation of ideals of beauty, and long sought to depict our bodies in paintings and drawings. Leonardo da Vinci, who went so far as to dissect human bodies in order to make more accurate depictions of them, is perhaps the single creator whose output best embodies the integration of the scientific and artistic aspects of the body.
This exhibition, with its theme of “the human body as the meeting place of science (medicine) and art,” was made possible with the cooperation of the Wellcome Trust, the world’s largest independent charity funding research into human health. Consisting of around 150 valuable medical artifacts from the Wellcome Collection and around 30 works of old Japanese and contemporary art, the exhibition presents an integrated vision of medicine and the arts, science and beauty. The show is a unique attempt to reconsider the science’s role in health and happiness and also the meaning of human life and death.

Mori Art Museum: Medicine and Art: Imagining a Future for Life and Love…
(hat tip: ScienceRoll)

OTC

mandometer Gadgets for Getting in Shape
Technology Review is profiling some of the more innovative gadgets that are on the market to help people stay fit. From personal activity monitors to the Mandometer (pictured) that keeps an eye on how much and how fast you consume your food, the selection of devices should provide an ample solution to anyone trying to obsessively track every aspect of their life.
Link: Gadgets for Getting in Shape…

3214gdf With Its Touch Based Tablet, Is Apple Aiming at Clinics?There are a lot of rumors swirling on the Internet about the upcoming unveiling of the Apple tablet computer. The TinyComb blog is reporting that Cedars-Sinai hospital execs have been meeting with Apple reps to push their upcoming touchscreen device for clinical applications.
Here’s the scoop:

While the whole tech news world sits around waiting to see what the official deal with the Apple tablet is and if anyone is going to buy this thing, Apple has been quietly ensuring the instant success of their tablet device. How? Apple has been going around targeting their first major paying customer for the device, which is not the average consumer, but the Healthcare industry (sorry fan bois, you’re not first priority here). This is a move widely overlooked by the media, since Apple has generally tried to own the consumer arena, and besides the film industry, hasn’t dominated enterprise. Well, now that they own the music, mobile, laptop and every teenager market, the medical industry is the next up to take over. [What's my intel? My Dad plays golf with Cedas-Sanai hospital execs, who say they have been getting frequent visits from Apple about a new device in the last 6 weeks].

Link: Apple’s Tablet Is For The Healthcare Industry…
(hat tip: INNOBLOG)

23498342 Video Scout Mini Camera for Endoscopic Applications
asd234d Video Scout Mini Camera for Endoscopic ApplicationsBC Tech out of Santa Cruz, CA has released a tiny video camera targeted at integration into small, and even disposable, endoscopic devices for high quality image transmission.
At only 3 millimeters in diameter and featuring four LED’s for lighting the scene, the camera has a 400 x 400 resolution CCD streaming at 30 frames a second. Perhaps this camera can be embedded into a cable that plugs into a device like an iPhone to make an endoscope straight out of Star Trek.
Product page: Video Scout…
Press release: BC Tech’s Tiny New Camera Gives Vision to Disposable Medical Devices…

award lr The 2009 Medical Weblog Awards Sponsored by Epocrates

With 2009 now in the history books, it’s time to select last year’s best of the best in the medical blogosphere. Welcome to the 2009 Medical Weblog Awards! This is the sixth year of the competition and these awards are designed to showcase the best medblogs, and to highlight the exciting and useful role that the medical blogosphere plays in medicine and society.
The categories for this year’s awards are:

  • Best Medical Weblog
  • Best New Medical Weblog (established in 2009)
  • Best Literary Medical Weblog
  • Best Clinical Sciences Weblog
  • Best Health Policies/Ethics Weblog
  • Best Medical Technologies/Informatics Weblog
  • Best Patient’s Blog
  • Nominations are now accepted in the comments section of this post. When nominating, please indicate the blog’s name and URL, as well as your thoughts why this particular blog deserves recognition. A blog can participate in more than one category, so please be precise which one(s). When we have all the nominees, Medgadget editors will sort through all the blogs, and we will select five blogs in each category based on merit, and on our own internal voting results.
    The following time line will be observed:

  • Nominations will be accepted until Sunday, January 24, 2010.
  • We will announce the finalists on Monday, January 25, 2010.
  • Polls will be open from Wednesday, January 27, 2010 and will close 12 midnight on Sunday, February 14, 2010 (EST).
  • Winners will be announced on Friday, February 19, 2010.
  • bbabbbab The 2009 Medical Weblog Awards Sponsored by Epocrates
    This year’s competition is sponsored by Epocrates, developers of the #1 medical application trusted by over 900,000 healthcare professionals. werwa The 2009 Medical Weblog Awards Sponsored by EpocratesEpocrates is generously donating an iPod touch to winners in each category along with a subscription to its most popular premium suite, Epocrates Essentials. The grand prize winner in the Best Medical Weblog category will receive an iPod touch with the top-of-the-line suite, Epocrates Essentials Deluxe, and a $50 iTunes gift card. Epocrates premium mobile suite provides clinicians with all they need at the point of care – from drugs to diseases and diagnostics. The grand prize package is valued at over $500.
    756778hi The 2009 Medical Weblog Awards Sponsored by Epocrates
    Of course, bragging rights are the ultimate reward, and we wish everyone the best of luck!
    Medgadget.com, as well as the individual blogs of our editors, are not eligible to participate in the awards.
    Voting for the awards will be open to all, but you will only be able to vote once. (No hacking or cookie manipulation will be tolerated — only one vote for each category from a particular IP address.)
    All final decisions will be made by our editors.
    Good luck to all!
    UPDATE: The 2009 Medical Weblog Awards Nominees…

    5634ee Global Warming Beliefs and The Hippocratic Oath: How BMJ Leadership Fails on Both
    After two years, it’s time we took another look at the practices and preachings of British Medical Journal‘s globe-trotting Editor-in-Chief, Dr. Fiona Godlee.
    You may know of Dr. Godlee from her work editing one of our favorite journals (their recent Christmas issue is another gem). Or, you may know her from her outspoken activism regarding global warming. Indeed, she has used the pages of BMJ as a bully pulpit, even as she describes herself as a “climate criminal.”
    4352godlee Global Warming Beliefs and The Hippocratic Oath: How BMJ Leadership Fails on BothYou can hit up the flashbacks at the bottom of this post to review our past interactions with Dr. Godlee (from those exchanges we created a page that updates her Carbon Footprint).
    Recently, however, Dr. Godlee and her staff upped the ante, and we feel it’s time to once again inquire into the discrepancies between what this woman and her company advocates, and what they do. In September 2009, BMJ together with Lancet has published an editorial proclaiming that if international leaders meeting for UN talks in Copenhagen do not agree to radical reductions in carbon emissions, the world will face an inevitable “global health catastrophe”. In addition, in June 2009, BMJ has published yet another editorial that calls for suspension of medical conferences to combat the Global Warming (the opinion piece, “Are international medical conferences an outdated luxury the planet can’t afford? Yes,” by Dr. Malcolm Green, professor emeritus of respiratory medicine from Imperial College, is reminiscent of the original editorial by Dr. Fiona Godlee, that has asked all clinicians, back in 2007, to suspend travels to medical conferences to save the planet from carbon dioxide).
    We must point this out: If Dr. Godlee and BMJ believe that Anthropomorphic Global Warming constitutes the number one threat to the health of humanity, she and her coworkers are actively engaged into practices that directly contradict their own opinions and, even the Hippocratic Oath itself.
    Back in 2007, in response to prior statements on her own blog, in articles, in multiple international conferences, and even on our own website, we wrote an open letter to Dr. Godlee and the rest of BMJ leadership to demonstrate concrete actions to reduce the carbon footprint of the publication. Those calls for the last two years went unanswered:
    1. BMJ continues to chop and reprocess trees. BMJ Group still distributes its pulp publication all over the world, via trucks, ships, planes, trains, and other modes of transportation.
    2. Dr. Godlee and other BMJ editors continue to travel the world over. In the last two years, she and her colleagues have attended conferences in the following places (all documented attendances): Vancouver, BC, Canada, Castro Brothers’ Havana, Cuba, African country of Mali (if you want to know where Mali is and what she did there, check out her blog post), Singapore, Amsterdam, Atlanta, Georgia, Oxford, UK, Birmingham, UK, Glasgow, Scotland, Paris, France, Vienna, Austria, Gastein, Austria, Verona, Italy, Boston, Massachusetts, Copenhagen, Denmark and more. To view the full extend of documented BMJ leadership’s sightings, check out the interactive map here.
    3. While the journal is touting to others to “lead by example,” and to abstain from meetings, BMJ is keeping its medical conferences business strong. A quick online search reveals a large number of upcoming medical conferences, all sponsored or organized by BMJ Group, including the conference in Nice, France and many BMJ Masterclasses slated all over the UK. Furthermore, while its editors preach restraint to the rest of us, BMJ Group continues to proselytize its conferences business in a special webpage.
    Now it’s 2010. We don’t want to debate the details of Anthropomorphic Global Warming, but we can accept and appreciate that BMJ‘s own editorial has stated global warming “leaves no room for complacency.” The doctors at BMJ believe that global warming is a threat to health, and CO2, in essence, is a poison. They demand action, from all of us.
    Yet they continue to travel extensively, and unnecessarily, generating patient-killing poisons as a byproduct of their business.
    We cannot help but recall the Third Tenet of the Hippocratic Oath: “I will neither give a deadly drug to anybody if asked for it, nor will I make a suggestion to this effect.”.
    BMJ’s leadership, and specifically Dr. Godlee, really must take the following steps to reduce and eliminate the company’s carbon footprint:
    1. BMJ has to stop production and distribution of all its print publications in Europe, North America, Australia, and other parts of the world that have broad internet penetration.
    2. BMJ has to curtail world wide travels of all of its leaders, at least of those who believe in the Anthropomorphic Global Warming and its effect on health, and vigorously promote teleconferencing.
    3. If the company leadership is asking other clinicians to abstain from the medical conference travels, BMJ should close its conference business, and transition its educational arm to an online format.
    4. To be responsible, BMJ should provide the medical community with a transparent and detailed plan on how the company will tackle the transition to a minimal carbon footprint.
    Before BMJ and its leadership asks the medical community (again) to make sacrifices, a journal with their reputation should “lead by example,” take its own words seriously, and properly protect our patients — the planet’s people.
    On the web: Carbon Footprint of Dr. Fiona Godlee, Editor of the British Medical Journal…
    Flashbacks: BMJ Urges Others, Fails to “Lead by Example” on Climate Change; Fionagate: An Illustrated, Interactive Website; Feet to the Fire: Responding to Dr. Godlee ; Carbon Footprint, or How to Spot Other People’s Garbage

    GI

    bil23nnad Cooks Zilver Biliary Stent Compares Favorably to Boston Scis Wallstent
    Cook Medical is touting a recent study that compares the effectiveness of the firm’s Zilver Biliary Stent to the most commonly used device, the Wallstent from Boston Scientific. Essentially, the conclusion of the international multi-center study, published in Gastrointestinal Endoscopy, is that the two stents have very similar performance (patency) characteristics, both exhibiting stent occlusions in the low 20% of cases. (The Zilver stent in a smaller 6mm diameter was found to exhibit a higher, 39.1%, rate of occlusion, hence that arm of the study was closed earlier than anticipated.)
    z234nn Cooks Zilver Biliary Stent Compares Favorably to Boston Scis Wallstent

    The MOZART study included a total of 241 patients in nine centers in the U.S., Canada and Europe who presented with malignant biliary obstructions – a complication associated with several forms of cancers – in which the bile ducts of the liver become blocked by tumors. Biliary obstructions or strictures impair liver function and cause a range of symptoms including abdominal pain, nausea, vomiting, fever and fatigue. The blocked ducts can be opened using stents inserted endoscopically that expand upon deployment. Plastic stents are cheaper than metal for this purpose, but data suggest that plastic stents occlude more readily when compared to SEMS, necessitating repeat procedures. In fact, SEMS have proved more robust and cost-effective in many clinical settings.
    According to the MOZART study, the 6-mm SEMS demonstrated a higher occlusion rate than the 10-mm SEMSs; therefore, the study agreed to close this arm to further patient entry and continue to follow the exiting enrolled patients. The remaining 10-mm SEMS patients revealed equal patency among SEMS.
    The two biliary stents in the MOZART study differ significantly in design, materials and mechanism of expansion, but achieved equal patency by several measures: for both, fewer than a quarter became occluded after placement over the life of the study. Treating physicians, who had more experience with Boston Scientific’s stent, reported the ease of positioning of the Zilver during the study.
    Cook Medical’s Zilver Biliary Stent is the first stent of its kind made of flexible laser-cut nitinol tubing. Nitinol, which is inherently kink-resistant, allows Zilver to conform to the ductal wall while providing reliable patency. Through the interlocking design construction, Zilver’s stent ends are atraumatic, potentially reducing the risk of ulceration or perforation. Its non-foreshortening design gives precise accuracy in placement; potentially reducing instances of migration and the need for repeat procedures. Additionally, four gold radiopaque markers at each end of the stent provide greater fluoroscopic visualization and exacting placement.
    Benefits and Offerings of the Zilver 635:

  • Zilver 635 has the markets only 6 FR introducer, the optimal platform for hilar and bifurcation stenting;
  • Utilizes Cook’s proprietary Flexor coil-reinforced introducer technology: a truly unique material that has excellent pushability and flexibility while providing a distinct advantage in stent placement due to its kink resistance;
  • The only system in the world that allows two stents to be placed simultaneously through a standard 4.2-mm channel duodendoscope, thereby increasing procedural efficiency;
  • Includes a shelf-less tip design to ensure smooth withdrawal of the introducer through the deployed stent.
  • zilb3 Cooks Zilver Biliary Stent Compares Favorably to Boston Scis Wallstent
    Press release: First and Only International Study of its Kind Shakes up Metal Biliary Stent Market…
    Product page: Zilver 635…
    Abstract in Gastrointestinal Endoscopy: Comparative performance of uncoated, self-expanding metal biliary stents of different designs in 2 diameters: final results of an international multicenter, randomized, controlled trial

    At the ongoing Consumer Electronics Show in Las Vegas, Engadget got a chance to try out a new breath activated computer mouse controller from Zyxio out of Henderson, Nevada. The yet to be released device looks like it’ll be marketed as an additional controller for video gamers and for other people doing tasks where the hands are already busy, like drivers. But if sufficiently effective, we might see it assist the disabled in controlling all kinds of helpful gadgets.
    Here’s Engadget‘s video:


    More from Engadget…