Archives: 11/2008

nicast mesh NovaMesh from Nicast
Nicast out of Lod, Israel, developers of fine electrospun polymer “nanofabric”, will be introducing the company’s new NovaMesh™ Ventral Hernia Mesh at Medica 2008 conference in Germany next week. We have profiled Nicast’s proprietary poly-urethane nanometric scale fiber scaffolding twice before (see flashbacks at the end of this post).
nicast mesh2 NovaMesh from NicastFrom the product page:

The NovaMesh Ventral Hernia Mesh features improved resistance to tissue adhesion on the visceral-facing surface, and promotes excellent tissue ingrowth on the fascial surface. The NovaMesh is the first hernia mesh to exploit the unique properties of electrospun nanofabric.
These include:

  • Improved resistance to tissue adhesion on the visceral-facing surface
  • Excellent tissue ingrowth on the fascial surface
  • Near-perfect flatness, no creasing or kinking following tight rolling and unrolling
  • Biomimetic electrospun nanofabric
  • Easy handling and laparoscopic insertion – all sizes can fit through a trocar
  • No shrinkage
  • Press release: Nicast to Introduce the NovaMesh™ Ventral Hernia Mesh at Medica 2008 in Germany
    Product page: NovaMesh™ Ventral Hernia Mesh …
    Flashbacks: Europe Green Lights Nanofabric-based AVflo Vascular Graft ; Nanofiber-based Vascular Grafts by Nicast

    CoreTx top CoreTx for Stroke Rehab
    CoreTx is a nifty wireless device that is intended to be used by stroke victims to help restore controlled limb movement. Working with gyroscopic technology similar to the one inside of a Nintendo Wii controller, the unit tracks the precision and speed of a limb’s movement and provides feedback to the user.
    CoreTx side CoreTx for Stroke Rehab

    Core:Tx® is a software and hardware system that interfaces with a patient, giving him or her real-time feedback on the position and movement of selected joints. At the same time this system provides the clinician with valuable objective data on the patient’s performance and abilities.
    Used under the guidance of a therapist or healthcare professional, Core:Tx turns rehabilitation into a wireless, game-like challenge that is entertaining and works for a variety of patients recovering from neuromuscular conditions as well as joint injuries. The Core:Tx system is compatible with and enhances existing rehabilitation, preventative and strengthening protocols.

    CoreTx product page…
    CoreTx Professional user manual (.pdf)…

    prostat cancer cell New Cooling Device May Reduce Prostatectomy ComplicationsTaking the prostate out is not easy, and it is associated with two terrible side effects: impotence, and urinary incontinence. Recently, robotic surgery has been one way to cut down on the complication rate, but it’s still not perfect.
    The UroCool device from InnerCool, a subsidiary of Cardium therapeutics, is a rectally placed catheter that keeps the prostate nice and frosty during a prostatectomy. The device is theorized to reduce post-op complications and is currently undergoing clinical studies at UC Irvine.
    Here’s some more info from the press release:

    Dr. Ahlering and his colleague Dr. David S. Finley are conducting clinical studies designed to demonstrate safety and confirm the potential benefits of localized cooling during robotic-assisted prostatectomy, which is now the most common surgical technique for prostate cancer. The UroCool(TM) catheter is designed to be placed within the rectal cavity adjacent to the prostate during surgery. UroCool is used in conjunction
    with InnerCool’s Celsius Control Console which circulates cold saline in a closed loop within the catheter to allow for localized cooling. Drs. Ahlering and Finley believe that therapeutic cooling during prostate surgery (which includes both traditional open surgical approaches and the newer robotic-assisted technique) can reduce tissue damage and inflammation and thereby provide a faster return of bladder control (continence) and possibly erectile function (potency). From a practical viewpoint, they liken this concept to icing a severely sprained ankle in order to minimize tissue injury and shorten the recovery process.

    The hope is that patients will be more likely to have elective prostatectomies by reducing the complication rate.
    Read the press release here
    Image: Prostate cancer cell. (Wellcome-Images)

    breast radar Ground Penetrating Radar Looks for Breast Cancer
    Researchers at Bristol University have developed a breast imaging system that uses radio waves to look for dense spots within tissue. Unlike mammography, the new system avoids the harmful effects posed by x-ray radiation.

    The radar breast imaging system is built using transmitters and receivers arranged around a ceramic cup, which the breast sits in. These transmitters view the breast from several different angles.
    In the initial stages of the study the team used mammogram images to compare similar abnormalities in the new 3D image produced from the radio breast imaging system.
    Professor Preece from the University’s Medical Physics, said: "I started off looking at breast tumour imaging in 1990 using a hand held scanner similar to ultrasound however it did not have enough sensitivity and that’s when I got to know some people in engineering and together we approached the EPSRC to help.
    "Using this engineering knowledge we built the machine using ground penetrating radar, a similar technique to land mine detection to take four hundred quarter of a second pictures of the breast to form a 3D image.
    "Women do not feel any sensation and it equates to the same type of radiation exposure as speaking into a mobile phone at arms length which makes it much safer.
    Mike Shere, Associate Specialist Breast Clinician at NBT, added: "Currently women are diagnosed in three ways: firstly by a clinician then by using imaging such as mammography and ultrasound and lastly by a needle biopsy.
    "The radar breast imaging system came to Frenchay in September this year and so far around 60 women have been examined using it.
    "It takes less time to operate than a mammogram approximately six minutes for both breasts compared with 30-45 minutes for an MRI, and like an MRI it provides a very detailed 3D digital image.

    Press release: New technology could revolutionize breast cancer screening …
    Related research article: EVALUATION OF A HEMI-SPHERICAL WIDEBAND ANTENNA ARRAY FOR BREAST CANCER IMAGING

     How Math May Solve SepticemiaThe next time your teenager complains, “But when am I ever going to use this?”, referring to math they are learning in school, now you can reply, “Septicemia!”
    As we know, septicemia occurs when bacteria enter the bloodstream from an infected organ or site, and despite many methods designed to reduce the spread of infections, fighting infections with antibiotics once they occur, and other supportive therapies, septicemia, or a resultant sepsis, remains a leading cause of death in hospitals. Could mathematics help us solve this problem?
    Well, the University of Michigan School of Medicine is researching mathematical approaches that may become a powerful ally in hunting down and destroying the bacteria that cause septicemia. Using complex mathematical techniques that model bacteria behavior in the bloodstream, scientists may be able to offer a mechanical approach to help rid the body of bacteria, which would be a welcome addition to our declining list of effective antibiotics.


    From the story released by the University of Michigan:

    John Younger M.D., M.S., and his team have more research to do before their models yield results that might affect human treatment. But already, they are seeing the potential for how to improve the models and use them to simulate different aspects of human bacteremia and sepsis.
    “We’re trying to understand the rules for how bacteria traffic in the bloodstream – and if you understand the timing of those events you might be able to better understand how best to detect the bloodstream infection when it’s present,” he says. “We’re also working on ways to fundamentally change the rules of engagement between the bacteria and the host. There are mechanical features at play in terms of getting these bacteria in flowing blood out. If we can change the mechanics of that interaction, then we can potentially have a therapy that the bacteria don’t really have an opportunity to defend against or develop resistance against. And that could be a useful therapy.”

    (more…)

    defib03 History and Science of Cardiac DefibrillatorsCardiac defibrillators have come a long way in the last half a century. If you pay enough attention, you will notice that defibrillators are ubiquitous: now readily seen hanging on public institution walls like first aid kits of old. IEEE Spectrum magazine has an extensive article covering the history of the defibrillator, including the pictured device invented by Dr. Claude Beck in the 1940′s at University Hospitals of Cleveland. Regulating the electric current to stimulate the heart is an interesting science from both the clinical as well as the engineering perspective, and Spectrum gives a rather in depth overview of the functionality of modern fully automatic units by tracing the device’s development through the years.
    A snippet:

    Kouwenhoven and Knickerbocker’s observation was picked up by a pioneering cardiac surgeon, Claude Beck, at the University Hospitals of Cleveland. He began delivering ac directly to the exposed hearts of animals he had put into ventricular fibrillation. Beck might have continued methodically with his animal experiments, except that in 1947 a 14-year-old patient’s heart stopped during surgery. Out of desperation, Beck ordered that his research unit be brought up from the hospital’s basement. This simple defibrillator consisted of a transformer to isolate the patient from the 110-volt ac wall supply, a variable resistor to limit the current to a heart-safe value, and two metal tablespoons with wooden handles to deliver the jolt to the exposed heart [see “Saved by a Spoon”].
    The first shock failed, so Beck administered a second. That brought the patient back to life, and the event made national news. But because so little was known about why the technique worked or how to improve it, these crude ac systems persisted for several years. Recipients of closed-chest ac defibrillation tended to suffer unpleasant side effects from the large steady currents, including broken ribs and damage to the heart ­muscle—if they were saved at all.
    Unknown to Beck and his colleagues in America, investigators in Europe and Russia were far ahead of them in animal research and were beginning to use a single pulse, or dc, defibrillation. In the 1890s, Jean-Louis Prévost and Frederic Batelli, two physiologists at the University of Geneva, revived animals with a capacitor discharge delivered directly to the heart.
    Decades later, one of their graduate students, Lina Schtern, moved to the Soviet Union and continued to refine the ­technique—that is, until she received a death sentence during a crackdown on intellectuals under Joseph Stalin. She was eventually pardoned by the dictator himself, who (according to accepted rumor) believed that she could bring people back from the dead.

    Read the whole thing at IEEE Spectrum

    clevelendclinic top10 Cleveland Clinics Top Ten Medical Innovations 2009The Cleveland Clinic has released their annual list of the top ten medical innovations of next year. Their criteria for selection include innovations that have a high probability of success, are supported by data, on or close to market, and that are likely to have significant clinical impact. And now to the list…

    1. Use of Circulating Tumor Cell Technology:
    Use of new technology to measure circulating tumor cells as a predictor of success of chemotherapy.
    2. Warm Organ Perfusion Device:
    Warm organ perfusion device to preserve organs for transplantation during transplant.
    3. Diaphragm Pacing System:
    Improvements in multi-spectral image analysis to assess multiple protein pathway configuration in a single sample/cell.
    4. Multi-Spectral Imaging Systems:
    Use of a diaphragm (phrenic nerve) stimulator to enable paralyzed patients to breath without the assistance of a mechanical ventilator.
    5. Percutaneous Mitral Valve Regurgitation Repair:
    Use of a special clip to percutaneously repair mitral valve regurgitation (MVR).
    6. New Strategies for Creating Vaccines for Avian Flu:
    Use of new strategies for creating vaccines for avian flu, including genetically-engineered virus-like particles (VLPs) as the basis for vaccines.
    7. LESS and NOTES Applications:
    Laparoendoscopic single-site surgery (LESS) and Natural Orifice Transluminal Endoscopy (NOTES) for nephrectomy, cystectomy, prostatectomy, colon resection, and other applications.
    8. Integration of Diffusion Tensor Imaging (Tractography):
    Integration of diffusion tensor imaging (tractography) with surgical navigation of the brain to minimize damage to fiber tracts during brain surgery.
    9. Doppler-Guided Uterine Artery Occlusion:
    Doppler-guided non-invasive transvaginal uterine artery occlusion for treatment of symptomatic uterine fibroids.
    10. Private Sector National Health Information Exchange:
    Use of a common exchange standard among participants to enable access through the Internet regardless of provider source.

    Lists like these give us a clue to how well we’ve been doing covering medical innovations over the years. Check out our previous coverage of these hot technologies to stay up to date!
    Flashbacks: Beating heart transplant, diaphragm pacing, virus-like particles, percutaneous mitral valve repair, and detecting circulating tumor cells
    Read more about Cleveland Clinic’s top ten list
    here

    bone tester1 Mechanical Sensor Teams Up With Ultrasound for Bone Monitoring
    Scientists at Empa, a Swiss research institute, have developed a mechanical pressure sensor that can be embedded within orthopedic implants, close to bone fractures, to provide physicians with post-operative status updates. The sensor features no electronics, and its results are read externally via ultrasound. According to Empa, the device is designed to monitor the healing process in broken bones as they grow back together.
    From Empa:
    bone tester Mechanical Sensor Teams Up With Ultrasound for Bone Monitoring

    The solution is in the form of a small, hollow spiral which sits on the implant together with a fluid reservoir. When the implant is subject to compression or tension the level of fluid in the spiral changes. This level is measured with the help of an ultrasonic device, and the resulting data allows the mechanical loading on the implant to be calculated. The ultrasonic image is, however, too indistinct to allow the fluid level to be determined visually, so the Empa researchers decided to analyze the ultrasonic signal in more detail. They quickly found a dependence between the ultrasonic echo generated over the complete spiral and the actual fill level – the weaker the ultrasonic echo measured, the higher the level, and therefore the greater the force acting on the sensor.
    The sensor produces reliable measurement data, as numerous experiments with artificial tissues – mixtures of gelling agent, glass ballotini and graphite powder, which depending on the mixing ratios allow different types of tissue to be simulated – have demonstrated. Not only that, it is also economic to manufacture, being very much cheaper than the existing electronic versions. The next step is to test the accuracy of the new method using various animal tissues, since each material has its own acoustic signature because it reflects and absorbs ultrasonic energy differently.
    In addition, the Empa scientists are investigating the idea of making the sensor out of biodegradable materials, in which case the device would simply dissolve away in the patient’s body after completing its task. The surgeon need not therefore sharpen his scalpel a second time, there being no need to remove the sensor when the fracture has healed!

    Press release: Monitoring broken bones without using electronics …

    GI

    philips ipill iPill for Electronic Drug DeliveryLast November we covered Philips‘ application for a patent that described an electronic swallowable capsule that would deliver drugs close to where they would be most effective, or best absorbed in the gastrointestinal tract. Now Philips is introducing the iPill, a prototype device that features a pump to release a drug, a radio to communicate with the ex vivo world, an on board computer, and a battery to power it all.
    Philips promises to show off the device in Atlanta at the annual meeting of the American Association of Pharmaceutical Scientists this month.
    Press release: Philips’ intelligent pill targets drug development and treatment for digestive tract diseases…
    More from Reuters
    Flashbacks: Philips Electronic Drug Delivery Pill