Archives: 11/2008

google flu Google Joins Nanny State to Monitor Flu?
Drudge is reporting that Google plans on releasing a tool to the federal government that uses data gathered from web searches for flu related keywords to notify health agencies where an outbreak might be happening. Lets for a minute ignore the privacy implications of this project and think of the potential benefits of an early warning system that notices patterns as soon as people start getting the sniffles.


Google explains its methodology:

We have found a close relationship between how many people search for flu-related topics and how many people actually have flu symptoms. Of course, not every person who searches for “flu” is actually sick, but a pattern emerges when all the flu-related search queries from each state and region are added together. We compared our query counts with data from a surveillance system managed by the U.S. Centers for Disease Control and Prevention (CDC) and discovered that some search queries tend to be popular exactly when flu season is happening. By counting how often we see these search queries, we can estimate how much flu is circulating in various regions of the United States.
During the 2007-2008 flu season, an early version of Google Flu Trends was used to share results each week with the Epidemiology and Prevention Branch of the Influenza Division at CDC. Across each of the nine surveillance regions of the United States, we were able to accurately estimate current flu levels one to two weeks faster than published CDC reports.
CDC uses a variety of methods to track influenza across the United States each year. One method relies on a network of more than 1500 doctors who see 16 million patients each year. The doctors keep track of the percentage of their patients who have an influenza-like illness, also known as an “ILI percentage”. CDC and state health departments collect and aggregate this data each week, providing a good indicator of overall flu activity across the United States.
So why bother with estimates from aggregated search queries? It turns out that traditional flu surveillance systems take 1-2 weeks to collect and release surveillance data, but Google search queries can be automatically counted very quickly. By making our flu estimates available each day, Google Flu Trends may provide an early-warning system for outbreaks of influenza.

Developing at Drudge
Project page: Google Flu Trends…

CNAP MONITOR 500 Continuous Noninvasive Blood Pressure Monitoring  with CNAP Monitor 500
CNSystems Medizintechnik AG, a medical technology firm out of Graz, Austria, has received FDA approval to market the company’s CNAP™ Monitor 500, that performs continuous noninvasive blood pressure monitoring. The unit can be used in conjunction with other monitoring systems or alone as a self contained, battery powered unit.
58779uyt1 Continuous Noninvasive Blood Pressure Monitoring  with CNAP Monitor 500
More about the technology and the device from the press release:
58779uyt2 Continuous Noninvasive Blood Pressure Monitoring  with CNAP Monitor 500

CNAP™ traces blood pressure changes through the patented CNAP™ cuff at the fingers and calibrates the derived values once in a while to an upper arm measurement. This way the physician is provided with blood pressure values is the one he/she is familiar with and the patient’s individual physiology is optimally taken care of. If the position of measurement is changed relatively to heart height, just trigger a new upper arm measurement for the recalibration to the new measurement situation…
The CNAP™ Monitor 500 measures non-invasive and continuous blood pressure in real-time and can predict responsiveness to fluid administration. In the perioperative setting, detecting blood pressure drops and their cause in time is crucial for peri- and postoperative outcome. However, until recently only invasive methods provided quality information to the clinician. CNAP™ provides reliable blood pressure monitoring comparable to invasive techniques and adds valuable information about fluid responsiveness of the patient non-invasively. This allows spreading the highest level of blood pressure monitoring to all perioperative settings where close blood pressure monitoring is indicated, but the risk and discomfort of invasive measurement is not justified.

Product page: CNAP™ Monitor 500 …
Product brochure (.pdf)…
Press release: CNSystems Medizintechnik AG Receives FDA Approval for CNAP(TM) Monitor 500…

pureheart Clean Shopping Carts Prevent Infections, Welcome GermaphobesToday’s Wall Street Journal is profiling a shopping cart sanitizing system, dubbed PureCart™, the makers of which claim an over 99% kill rate of common pathogens that could be present on the carts. Germaphobic parents can now forget about bringing wet wipes to the store in a futile attempt to clean every object and crevice their kids can get their hands on.
Here’s some info about the system from the manufacturer:

The Solution Control System is user-friendly, simple to operate and reliable. It consists of a pump, tanks and control components that are housed in a separate enclosure. The system requires only a connection to a 110 VAC, 20 Amp power source, a fresh water supply and a drain.
The simple-to-use master control panel operates the start/stop of the unit, as well as provides indications of critical components and function. A key switch allows the system to run, or use the remote start/stop control to initiate unit operation.
The enclosure is a compact fiberglass unit featuring door protectors at the entrance and exit. The unit features a fixed guide system to insure the carts track through the unit at the proper distance from the spray nozzles. The enclosure is sturdy, yet portable, with retractable casters. It can also be secured for semi-permanent installation. The purifying mist is substantially contained in the enclosure through the use of flexible unit dividers. A sloped floor directs any overspray and excess solution to a drain connection.

Wall Street Journal video from a supermarket that installed the PureCart:


More from WSJ
Product page: PureCart Systems…

fmri brain Visualized: Hearing Inside the BrainResearchers at Maastricht University in Holland developed an innovative technology that uses functional MRI and computer software to reveal specific details of the hearing process. In gathered fMRI data scientists were able to identify who the subject was listening to and what that person was saying. Even though the study involved only three speakers pronouncing three simple sounds, the technology paves the way for future research into understanding how the brain processes auditory information.

Seven study subjects listened to three different speech sounds (the vowels /a/, /i/ and /u/), spoken by three different people, while their brain activity was mapped using neuroimaging techniques (fMRI). With the help of data mining methods the researchers developed an algorithm to translate this brain activity into unique patterns that determine the identity of a speech sound or a voice. The various acoustic characteristics of vocal cord vibrations (neural patterns) were found to determine the brain activity. Just like real fingerprints, these neural patterns are both unique and specific: the neural fingerprint of a speech sound does not change if uttered by somebody else and a speaker’s fingerprint remains the same, even if this person says something different.
Moreover, this study revealed that part of the complex sound-decoding process takes place in areas of the brain previously just associated with the early stages of sound processing. Existing neurocognitive models assume that processing sounds actively involves different regions of the brain according to a certain hierarchy: after a simple processing in the auditory cortex the more complex analysis (speech sounds into words) takes place in specialised regions of the brain. However, the findings from this study imply a less hierarchal processing of speech that is spread out more across the brain.

Press release: Maastricht University researchers produce ‘neural fingerprint’ of speech recognition …
Abstract in Science
Image credit

rhimage In the Works: Heart Powered Implanted PacemakerAccording to research presented at the American Heart Association’s Scientific Sessions 2008, a collaborative project to develop a device to harness the energy produced by the heart to power an implantable pacemaker is generating great deal of promise. A study of the SIMM, a catheter-mounted generator that can be placed on a conventional pacemaker or defibrillator lead, which uses balloons within the right atrium and ventricle to generate electricity, shows that the technology to develop self powering implantable cardiac devices may become clinically feasible.
From the press statement by the American Heart Association:

In a trailblazing experiment, a microgenerator powered by heartbeats produced almost 17 percent of the electricity needed to run an artificial pacemaker.
“This was a proof-of-concept study, and we proved the concept,” said Paul Roberts, M.D., first author of the study and a Consultant Electrophysiologist at Southampton University Hospital in the United Kingdom. “Harvesting surplus energy might be a major transition in implantable pacemakers and defibrillators because engineers will have more energy to work with.”
In their study, researchers found:

  • At a heart rate of 80 beats per minute (bpm), the device yielded an average harvested energy of 4.3 microjoules per cardiac cycle.
  • Increasing changes in the heart rate produced corresponding increases in energy. At 104 to 128 bpm, the harvested energy level increased 140 percent.
  • Decreases occurred when the researchers slowed the heartbeat or lowered blood pressure.
  • Implantation and surplus energy harvesting caused no significant injury to the lining of the heart’s chambers.
  • The innovative generator — called the self-energizing implantable medical microsystem (SIMM) — helps the heart produce more than enough energy with each beat to pump blood.
    The SIMM uses two compressible bladders and a microgenerator mounted on the lead of a pacemaker or defibrillator, the wire that connects the device to the heart.
    The lead is attached to the end of the right ventricle, and the bladders relay the energy from the pressure of each heartbeat to the microgenerator, which transforms it into electricity for use by the battery.

    Press release: Heart’s surplus energy may help power pacemakers, defibrillators …
    SIMM device technology page

    There are five days left to submit your story to our medical sci-fi writing contest. The contest is sponsored by the generous folks from Epocrates, who will provide the winner with the latest version of Epocrates Essentials Deluxe, a premium mobile suite of drugs, diseases and diagnostics that also features a medical dictionary, coding reference, clinical calculators and more, as well as the latest Palm® Tungsten™ E2 handheld. Medgadget will award the winner with a box set The Complete Wreck (A Series of Unfortunate Events, Books 1-13) by Lemony Snicket. Your entries will be judged by a panel made up of Medgadget staff joined by Dr. Allen Roberts from GruntDoc, Dr. Val Jones from Getting Better, and Amy Tenderich from Diabetes Mine.
    More details here

    intervene needle InterVene Needle Prevents Accidental PricksMedica 2008 conference in Düsseldorf is next week, but all sorts of companies are already showcasing their devices and technologies. InterVene Ltd. out of Staveley, UK has announced that the company will be presenting to the world its manually retractable hypodermic safety needle that goes on all sorts of commonly-used luer lock or luer slip syringes via an extrinsic attachment. Interestingly, despite this arrangement the device has only 0.03ml of dead space, “significantly less than the potential residual contents of the needle itself and well within the requirements of the International Standards Organisation (ISO) for deadspace,” the company says. The company also proclaims that InterVene Safety Needle is “the world”s first manually retractable, hypodermic safety needle.” But we are not 100% sure about that, to be frank.
    Nonetheless, here are the features from the product page:

  • Cost-effective solution to reduce needlestick injuries
  • Quick and easy to use, varying little from standard practice
  • Fits commonly-used luer lock or luer slip syringes
  • Fingers need never go forward of the contaminated needle
  • Low angle of entry and auto-alignment of bevel during venepuncture [sic]
  • Single-handed operation possible throughout
  • Impossible to reuse once the safety feature has been activated
  • Complies with ISO standards for deadspace
  • Suitable for intravenous, intramuscular and subcutaneous injection
  • Completely eliminates the chances of re-capping the needle cannula
  • Available in a variety of gauge sizes
  • safety needle InterVene Needle Prevents Accidental Pricks

    InterVene Safety Needle works particularly well with certain blood collection systems as a multi-sample needle.
    1. Automatic bevel alignment speeds up the needle insertion process.
    2. The needle’s offset design offers a very shallow angle of entry to the vein reducing the risk of popping the vein.
    3. The transparent cap of InterVene Safety Needle ensures that flashback visualisation of blood is immediate.
    These features are designed to assist the phlebotomist whilst offering a safety needle and reducing disposal costs.

    Device page: InterVene Manually Retractable Hypodermic Safety Needle …
    Press release: World’s first manually retractable safety needle unveiled at MEDICA …

    morbid auction2 Rare and Unusual Medical Book Collection Going to AuctionPBA Galleries in San Francisco will be hosting an auction selling off the medical and science library of Dr Gerald I. Sugarman. The good doctor must have been a bit of a quirk, judging by the morbid oddities and strange selections in the collection.
    Morbid Anatomy blog explains:

    A very kind Morbid Anatomy reader has alerted me to the upcoming Medical & Science Library of Gerald I. Sugarman, MD auction at PBA Galleries in San Francisco. The auction, which will take place on November 20th, features rare book, prints, instruments and ephemera from the realms of medicine, science and natural history.

    View the collection (228 books and instruemnts) to be auctioned off..
    (hat tip: Morbid Anatomy)

    leica LED Cool Light Microscopy with Leica DM IL LED
    Leica has released a new inverted routine microscope that features LED (light emitting diode) illumination of the target. LED’s tend to run much cooler, and so do not disturb samples that are sensitive to temperature fluctuations.
    More about the microscope from the press release:

    The low-maintenance light source with no heat build-up, the long free working distances and generous space for operation and the system’s high stability, create ideal conditions for microscopy with live samples. The Leica DM IL LED and the fluorescence variant Leica DM IL FLUO are exceptionally versatile and can be individually configured with a wide range of optics and accessories – advantages that are unique in this class of microscope.
    The Leica DM IL LED is suitable for a wide variety of cell and tissue culture examinations in biology and medicine, for studies in development biology or micromanipulation all the way up to live cell experiments in transgenics or electrophysiology. The Leica DM IL FLUO variant offers versatile
    application potential for fluorescence applications such as GFP labeling and can also be supplied with LED fluorescence illumination on request. Featuring an energysaving automatic shutoff, the compact illumination unit integrates a pre-centered LED with a lifetime of 50,000 hours – no more need for lamp change! The 10 watt power of the LED is fully converted into light.

    leica LED2 Cool Light Microscopy with Leica DM IL LED

    The transmitted light illumination, optimized condensers and contrasting techniques are specially geared to cytobiological applications. All available contrasting techniques can be easily and quickly adjusted to individual requirements. The integrated modulation contrast (IMC) is a special advantage. This unique technique, further developed by Leica Microsystems, does not require special objectives. The microscope is highly compatible with components of Leica research microscopes. For the first time, condensers have been designed for the Leica DM IL LED that are suitable for all contrasting techniques. With its working distance of at least 80 mm and an aperture of 0.30, the S80 condensor gives the greatest possible amount of space around the sample whilst providing optimum contrast. The continuously adjustable condenser height offers unique flexibility when using peripheral microtools. With an aperture of 0.45 and at least 40 mm working distance, the S40 condenser enables particularly high resolutions – ideal for phase contrast and IMC.

    Press release: First Inverted Routine Microscope with LED Light Source…
    Product page: Leica DM IL LED