Archives: 6/2008

36553erg ERGYS2 Shows Positive Results as Exercise Option for Paraplegics
MTB Europe is reporting about a study conducted on paraplegics using an electric muscle stimulating training system from Therapeutic Alliances Inc. out of Fairborn, Ohio, a device called ERGYS2. One of the early adopters of this system was the late Christopher Reeve.

In an exercise study completed last year, patients who were paralysed from the chest or waist down experienced an average increase in their oxygen uptake by 25% and in their heart pumping volume by fully 37% after just eight weeks of training.
Never before has so much improvement or such impressive results been documented in this patient group.
The Ergys 2 is a stationary training bicycle, where the patient’s legs and feet are strapped to a leg holder and pedals. Electrodes are then fastened to the patient’s thigh and seat muscles, and electrical impulses trigger the muscles to contract and relax.
The impulses are computer controlled to guarantee the best possible effect. Even though it may seem like artificial training, it is real enough as it’s the patient’s own muscles that are working. And it is movement that demands energy: the blood flow increases, and the pulse goes up. The exercise has an effect on muscle mass, muscle strength, oxygen uptake and the heart’s pumping volume.

More at MTB Europe
Product page: ERGYS2

fsebroadcast Complimentary eBroadcast from Frost & Sullivan
For those directly working in the medical device industry, Frost & Sullivan will be hosting a complimentary eBroadcast focusing on creating company growth by giving attention to the perceived value that customers hope to gain out of the relationship. The event, to be held next Wednesday, June 18, will feature speakers from Exogen, Ply Gem, and Frost & Sullivan, giving emphasis to practical approaches for growth strategies.
For more information and to register, go to the eBroadcast home page
Medgadget is a proud sponsor of this event.

carobnautes Carbon Nanotubes as Ultra Fast Membrane Transport Channels
At Lawrence Livermore, scientists have developed carbon nanotubes that can in a basic way selectively pass a number of different materials.
From the LLNL press release:

In biological systems, the membranes often contain a slippery inner surface with selective filter regions made up of specialized protein channels of sub-nanometer size. These pores regulate cellular traffic, allowing some of the smallest molecules in the world to traverse the membrane extremely quickly, while at the same time rejecting other small molecules and ions.
Researchers at Lawrence Livermore National Laboratory are mimicking that process with manmade carbon nanotube membranes, which have pores that are 100,000 times smaller than a human hair, and were able to determine the rejection mechanism within the pores.
“Hydrophobic, narrow diameter carbon nanotubes can provide a simplified model of membrane channels by reproducing these critical features in a simpler and more robust platform,” said Olgica Bakajin, who led the LLNL team whose study appeared in the June 6 online edition of the journal Proceedings of the National Academy of Sciences.
In the initial discovery, reported in the May 19, 2006 issue of the journal Science, the LLNL team found that water molecules in a carbon nanotube move fast and do not stick to the nanotube’s super smooth surface, much like water moves through biological channels. The water molecules travel in chains – because they interact with each other strongly via hydrogen bonds.
“You can visualize it as mini-freight trains of chain-bonded water molecules flying at high speed through a narrow nanotube tunnel,” said Hyung Gyu Park, an LLNL postdoctoral researcher and a team member.
One of the most promising applications for carbon nanotube membranes is sea water desalination. These membranes will some day be able to replace conventional membranes and greatly reduce energy use for desalination.
In the recent study, the researchers wanted to find out if the membranes with 1.6 nanometer (nm) pores reject ions that make up common salts. In fact, the pores did reject the ions and the team was able to understand the rejection mechanism.
“Our study showed that pores with a diameter of 1.6nm on the average, the salts get rejected due to the charge at the ends of the carbon nanotubes,” said Francesco Fornasiero, an LLNL postdoctoral researcher, team member and the study’s first author
Fast flow through carbon nanotube pores makes nanotube membranes more permeable than other membranes with the same pore sizes. Yet, just like conventional membranes, nanotube membranes exclude ions and other particles due to a combination of small pore size and pore charge effects.

Press release: Livermore researchers use carbon nanotubes for molecular transport …

photocathode gun h1 X Ray Linear Accelerator, A New Ultra Microscope Into LifeCornell University, thanks to a major grant from the NSF, is moving forward on building an ultra powerful, ultra fast x-ray machine that promises to capture biomolecular processes happening in full motion video. Using technology developed at the university, called energy-recovery linac (ERL), the plan is to build a mile long linear accelerator on which multiple research projects can operate at the same time.
From the press release:

Moving beyond traditional X-ray crystallography systems–where the arrangement of atoms in crystalline material is revealed by analyzing the way X-ray beams are scattered from electrons in the crystal–the energy-recovery linac offers significant advantages. For one, materials subjected to ultrabright X-ray pulses need not be in crystalline form. And the tightly focused beam allows studies at much smaller scales.
As envisioned and invented by experimental physicists at Cornell, energy-recovery linear accelerators produce high-energy, pulsed X-ray beams by injecting electrons into the electromagnetic fields of a series of superconducting microwave cavities in a linear accelerator. Then, in a return loop, the electron beam is turned into X-rays by passing through undulators, which force the beam to oscillate to the right and left of its mean path with horseshoe magnets of alternating orientations. The pulsed X-rays are now ready for studies in multiple stations at the facility.
While the ERL X-ray beam loses about 0.04 percent of its energy during oscillation, 99.98 percent of its remaining energy is recaptured into the electromagnetic fields when the electrons are re-injected into the linac for deceleration–providing energy to accelerate subsequent bunches of electrons.
Compared to a traditional storage-ring X-ray source, such as CHESS, which recycles electrons billions of times but suffers from a compromised beam size, ERLs send each bunch of electrons through the undulators only once. Again and again, ERLs recover and reuse energy that accelerates electron bunches, while maintaining very small beam size–the key to the brilliance needed to study intimate details at the nano-scale.

Full story: Brightest X-ray Vision at the Nano-scale…
Video of Joel Brock of Cornell University, explaining the workings and hopes for the new project.

rewire Bacterial Chemical Sensors on the Horizon?New research out of MIT has deciphered part of the bacterial communication network that has long frustrated scientists. The multitude of communication pathways in bacteria share common enzymes, yet they are still able to communicate without any interference or “crosstalk.” The MIT scientists were able solve this problem, and even program their own bacterial communication pathways, by finding pairs of amino acid co-evolution. Here’s more on the discovery from MIT:

“If an organism has tons of this class of signaling pathway, why do we not get a lot of crosstalk?” said Laub. “How does the kinase pick out the right target?”
Based on earlier studies, the MIT researchers theorized that the specificity of the interaction is determined by a subset of amino acids on the histidine kinase and a corresponding subset of amino acids on the response regulator.
To confirm their theory, they looked for patterns of amino acid co-evolution in pairs of histidine kinases and their target response regulators.
Co-evolution occurs when a mutation in one of the two proteins is followed by a secondary mutation in the corresponding amino acid on the other protein, allowing the protein pair to maintain their interaction.
After searching a vast database of nearly 1,300 protein pairs, they identified a small set of co-evolved amino acids. They then confirmed that these amino acids govern signaling specificity by successfully rewiring five of the pathways by mutating the target amino acids.
Such manipulation could allow scientists to engineer bacteria that exhibit novel behavior such as glowing when they detect the presence of a pollutant such as toluene, said Laub.

Cheap chemical sensors that you could simply grow in a beaker would be incredibly useful.
Press release: MIT researchers unravel bacteria communication pathways …
Image caption: Diagram shows the structure of a histidine kinase (blue ribbons) and its target response regulator (green ribbons). The specificity of the interaction between the two proteins is primarily determined by the orange and red amino acid residues.

naootutebetop A Single Cell Pedometer Developed
Scientists at Fraunhofer Institute for Applied Optics and Precision Engineering have developed an optical sensor that can quantify the force that a cell exerts on a special surface as it moves across it, which should allow for creating somatic cell sorting machines and single cell diagnostic devices. The project is a part of the European Information Society Technologies initiative.
naootutebeside A Single Cell Pedometer Developed

It consists of a smooth surface that is studded with 250,000 tiny plastic columns measuring only five microns in diameter, rather like a fakir’s bed of nails. These columns are made of elastic polyurethane plastic. When a cell glides across them, it bends them very slightly sideways. This deflection is registered by a digital camera and analyzed by a special software program. The researchers working with project manager Dr. Norbert Danz of the Fraunhofer Institute for Applied Optics and Precision Engineering IOF in Jena have already shown that their ‘Cellforce’ sensor works. It will be the task of initial biological tests to show how different cell types behave. “Analysis of cell locomotion is important for numerous applications,” says Danz. “It could be used to check whether bone cells are successfully populating an implant, or how well a wound is healing.”
Developing the sensor was no easy undertaking. For one thing, the columns have to be coated in such a way that living cells are happy to move across their tips. The cells would otherwise avoid the tips and continue their journey lower down between the columns. In that case, there would be no deflection at all. Danz had the task of adapting the microscope required for cell magnification to make it exactly right for the application. Building the delicate column structure developed by researchers at the Fraunhofer Institute for Manufacturing Engineering and Applied Materials Research IFAM in Bremen is no less tricky: The researchers press liquid plastic at a pressure of 2000 bar into a negative mold and allow it to harden. It is a challenge even to manufacture the required mold, with its 250,000 micron-sized holes. To allow cost-effective production of the ‘Cellforce’ sensor in future, the researchers utilize commercially available plastics and well-established techniques from chip manufacture. The first ‘Cellforce’ prototype is expected to be ready in a year’s time.

Press release: Measuring the footprint of cells …
Project info page: Development of a single cell based biosensor for subcellular on-line monitoring of cell performance for diagnosis and healthcare…

oohhabaneros How Spicy is Your Meatball?An Oxford University professor has come upon a method that may one day replace the subjective, volunteer based Scoville testing method for determining the hotness of foods, with an objective chemical method using nanotubes and something called adsorptive stripping voltammetry.
Priding ourselves on being connoisseurs of the habanero pepper, we are somewhat saddened by the potential loss of tasting volunteer positions, but the scientists in us have been hoping for a more objective methodology.
Read on at The Guardian
(hat tip: Gizmodo)
Image by code poet..

52464tr Mechanical Hand With an Extra Sense of Touch
Intel researchers are showing off electrolocation technology implemented into a mechanical hand, a system that allows artificial fingertips of the hand to sense the presence of objects around them, before making physical contact. Essentially this may provide for faster response movements of mechanical prostheses, and is another sign that artificial limbs are overtaking our natural ones, be it strength, agility, or sensing features. The technology could also one day be incorporated into all kinds of haptic surgical robotic devices.
Check out the video of Wired editors playing with the device:


More from Wired
(hat tip: Gizmodo)

tanitascale xl Tanita Body Composition MonitorAn interesting personal scale, if it can be called in such a limited way, has been put to our attention as a nifty present for the health conscious and gadget obsessed man in your family. The device claims to provide accurate muscle mass and body fat numbers for each arm and leg, in addition to the body on the whole. And these and other numbers can be tracked via a graph screen on the top of the unit.
Our new father is planning to review the device hands on (feet on?) in the coming days to see if one needs to know Fortran to operate this thing.
Product page: Tanita BC558 Segmental Body Composition Monitor