Archives: 4/2008

movie3 cd Scientists Create Biomolecular Movies
Investigators from the Argonne National Laboratory, using the Advanced Photon Source, an X-ray synchrotron covered by us many times before, were able to reconstruct real motions of biological molecules in solutions. Pictured above is animation of the molecular structure of porphyrin changing along “with a calculated X-ray scattering pattern that corresponds to the structure of a light-harvesting porphyrin array.”

Biological and organic molecules in solution are far more complex than the standard crystalline structures of salt or metals since they are constantly moving and changing over time. These motions have not yet been seen directly, but scientists using the high-intensity X-rays at the Advanced Photon Source have measured images that are "blurred" by these motions and have used them to create more accurate movies of molecular motions.
Computer simulations are currently the only way to visualize molecular motions in solution, but researchers have not had a means to check the accuracy of these simulations for complex molecules. For the first time, scientists can see the movements first hand and compare them to their theoretical counterparts.
" The blurring that we see in our solution X-ray patterns are remarkably sensitive to the type of the molecular motion," senior chemist David Tiede said. "For the first time, we are able to test the accuracy of the simulation and change it to fit data better. Without it, we had no way of knowing how accurate the models were."
Tiede hopes an improved accuracy in molecular modeling will give insights into the structure and behavior of the molecules. Collaborators at the National Institutes of Health have used this approach to help determine structures of important biological molecules.
Tiede and his collaborators also plan to examine how a structure reacts to an outside stimulus. By using a laser to excite the atoms, he will create a movie that shows how the molecule reacts to the initial laser pulse and also how it returns to a stable condition.
"We hope to establish between’good’ and’bad’ molecular actors in important chemical processes like photosynthesis, solar energy and catalysts," Tiede said. "Once we see that, we can make these processes work better."

Press release: Argonne scientists develop techniques for creating molecular movies…

68768gw1 GeeWhiz Condom Catheter: Its Medicare Approved   Diapers Are Not!
For the latest in leak proof convenience and comfort, check out the GeeWhiz Condom Catheter from Leading Edge Innovations Inc., the winner of this year’s Medical Design Excellence Awards.
68768gw2 GeeWhiz Condom Catheter: Its Medicare Approved   Diapers Are Not!According to the manufacturer, the product “has a fantastically high satisfaction rating by the patients and as important, their caregivers.” We can’t wait to try it on:

  • Patented & Patent Pending Technology for a “leak proof” seal
  • No glue or skin adhesives required.
  • The GeeWhiz® is easy to apply — by one’s self or your caregiver
  • It’s also easy to remove
  • It features a quick connect and disconnect for use at day or night
  • It has a leak proof seal so you can rest assured
  • Cannot accidentally be removed
  • We are skeptical about the last point: if they can pull out central lines and chest tubes, they can definitely pull off an external condom catheter.
    Product page: GeeWhiz and Sizing Guide
    Press release: 33 Innovative Products Win Medical Design Excellence Awards…

    45343fl How Endogenous Steroids Rule on the Trading Floor
    An interdisciplinary group of scientists from the University of Cambridge decided to take a look at trading behaviors of male brokers in the City of London, and found that sell and buy decisions, and their successes, are often linked to hormonal concentrations of testosterone and cortisol.
    From the abstract of the study, published at Proc. Natl. Acad. Sci.:

    Little is known about the role of the endocrine system in financial risk taking. Here, we report the findings of a study in which we sampled, under real working conditions, endogenous steroids from a group of male traders in the City of London. We found that a trader’s morning testosterone level predicts his day’s profitability. We also found that a trader’s cortisol rises with both the variance of his trading results and the volatility of the market. Our results suggest that higher testosterone may contribute to economic return, whereas cortisol is increased by risk. Our results point to a further possibility: testosterone and cortisol are known to have cognitive and behavioral effects, so if the acutely elevated steroids we observed were to persist or increase as volatility rises, they may shift risk preferences and even affect a trader’s ability to engage in rational choice.

    More from Nature: The testosterone of trading…
    Paper: Endogenous steroids and financial risk taking on a London trading floor Proc. Natl. Acad. Sci. USA, 10.1073/pnas.0704025105
    Image credit: miskan: Kuwait Stock Exchange

    ENT

    ear2 Lyric Hearing Aid
    The New York Times has an article on the impressive Lyric hearing aid from InSound Medical of Newark, California. With the help of miniaturization and smart use of materials, the device is made to be inserted within millimeters of the ear drum and worn 24 hours a day. Because of its proximity to the ear drum and the device’s size, the internal battery will supposedly run the unit for at least a month.

    Typically, anything that clogs the ear canal would trap moisture and pose an infection risk, but the Lyric is surrounded by a spongy material that allows moisture to escape. Because it sits so close to the ear drum, doctors say that it works more efficiently and that sounds are more natural because they don’t have to be amplified as much.
    When the Lyric’s battery dies, the entire device is replaced. Patients do not pay for a new device every time; instead, they pay an annual subscription fee of $2,900 to $3,600 for both ears (less if the hearing loss is in only one ear). Insurance plans typically do not cover the cost of the Lyric, or any other hearing device.
    A magnet is used to control the volume, turn it on and off and remove it when the battery runs out. It takes only a few minutes for a doctor to insert a replacement device.

    More from the New York Times
    Animation showing how the Lyric works
    Product page: Lyric Technology

  • Drug Safety Monitoring for the 21st Century … [WSJ]
  • As Factories Close, Health Care is ‘Employer of Last Resort’ … [WSJ]
  • Study challenges notion of ‘pandemic’ flu… [MIT]
  • The testosterone of trading… [Nature]
  • A genetic cause for iron deficiency… [Children's Hospital Boston]
  • Anaesthetic drug ‘numbs memory’ … [BBC]
  • MMR doctor admits ethics failing … [BBC]
  • In Blood Vessel Stents, Innovative Materials Allow Better Control, Delivery of Gene Therapy… [Children's Hospital of Philadelphia]
  • Boston Scientific Announces Japanese Approval of Heart Failure Lead… [Boston Scientific]
  • Philips to acquire Chinese patient monitoring company…… [Philips]
  • Husbands with OSA are More Likely to Adhere to CPAP if their Wives Share the Bed… [American Academy of Sleep Medicine]
  • Sturdy synapses: Researchers show that brain cell signaling is regulated by phosphate … [RIKEN Research]
  • NIH’s National Library of Medicine Opens Exciting New Interactive Exhibition, “Against the Odds: Making a Difference in Global Health”… [NIH]
  • 35434sta2 Open Aortic Stapler Approved in EUJust over two weeks ago we covered the Open Aortic Stapler from Israeli ES Vascular, Ltd, a device designed to allow for “one shot stapling of synthetic grafts to aorta in open repair of abdominal and thoracic aneurysmal and occlusive disease, replacing lengthy and cumbersome manual suturing in these major procedures”. The company just announced that the EU has awarded the device with a CE Mark of approval for marketing in Europe.
    Press release: ES Vascular Receives CE Mark for its First Aortic Stapler for End-to-End Anastomosis Between Synthetic Grafts and Aorta During Open Repair of Aortic Aneurysmal and Occlusive Disease…
    Product page with video demonstrating the device: Staplers for Open Aortic Surgery

    89544br Not Free Will After All?
    The latest neurophysiology research is showing that unconscious processes in the brain develop up to seven seconds before the conscious decision is made, and these processes could be predictive of the decision itself. Here’s what investigators from the Max Planck Institute for Human Cognitive and Brain Sciences in Leipzig, in collaboration with the Charité University Hospital and the Bernstein Center for Computational Neuroscience in Berlin, have demonstrated, as reported by the Max Planck Society for the Advancement of Science:

    The researchers from the group of Professor John-Dylan Haynes used a brain scanner to investigate what happens in the human brain just before a decision is made. "Many processes in the brain occur automatically and without involvement of our consciousness. This prevents our mind from being overloaded by simple routine tasks. But when it comes to decisions we tend to assume they are made by our conscious mind. This is questioned by our current findings." (Nature Neuroscience, April 13th 2008)
    In the study, participants could freely decide if they wanted to press a button with their left or right hand. They were free to make this decision whenever they wanted, but had to remember at which time they felt they had made up their mind. The aim of the experiment was to find out what happens in the brain in the period just before the person felt the decision was made. The researchers found that it was possible to predict from brain signals which option participants would take already seven seconds before they consciously made their decision. Normally researchers look at what happens when the decision is made, but not atwhat happens several seconds before. The fact that decisions can be predicted so long before they are made is a astonishing finding.
    This unprecedented prediction of a free decision was made possible by sophisticated computer programs that were trained to recognize typical brain activity patterns preceding each of the two choices. Micropatterns of activity in the frontopolar cortex were predictive of the choices even before participants knew which option they were going to choose. The decision could not be predicted perfectly, but prediction was clearly above chance. This suggests that the decision is unconsciously prepared ahead of time but the final decision might still be reversible.
    "Most researchers investigate what happens when people have to decide immediately, typically as a rapid response to an event in our environment. Here we were focusing on the more interesting decisions that are made in a more natural, self-paced manner", Haynes explains.
    More than 20 years ago the American brain scientist Benjamin Libet found a brain signal, the so-called "readiness-potential" that occurred a fraction of a second before a conscious decision. Libet’s experiments were highly controversial and sparked a huge debate. Many scientists argued that if our decisions are prepared unconsciously by the brain, then our feeling of "free will" must be an illusion. In this view, it is the brain that makes the decision, not a person’s conscious mind. Libet’s experiments were particularly controversial because he found only a brief time delay between brain activity and the conscious decision.
    In contrast, Haynes and colleagues now show that brain activity predicts even up to 7 seconds ahead of time how a person is going to decide. But they also warn that the study does not finally rule out free will: "Our study shows that decisions are unconsciously prepared much longer ahead than previously thought. But we do not know yet where the final decision is made. We need to investigate whether a decision prepared by these brain areas can still be reversed."

    Press release: Unconscious decisions in the brain…

    43553pl Human Placenta is Not a Nutritional SupplementWell, that’s what the FDA says at least. It seems Herbal Science International, Inc. (aka Jen-On Herbal Science International, Inc.) is recalling a number of dietary supplements for containing ephedrine alkaloids, aristolochic acid and human placenta?! From the FDA press release:

    Finally, the company is recalling Seng Jong Tzu Tong Tan, a product that contains human placenta. Human placenta may transmit disease and dietary supplements that contain it may not be lawfully marketed in the United States.

    In a lot of ways, this raises more questions than answers. What is placenta (basically a bloody membrane) supposed to treat? How was it processed to make into a pill? Where are they getting all of these placentae?
    It’s turning out to be a bad day for Asian pseudoscientific remedies.
    More from the FDA

    53245bl Rhino Horns as Aphrodisiacs? Not These OnesSome consumers of black market Rhino-horn soup (apparently a delicacy in Asia) may get more (or less?) than they bargained for. Two horns stolen from a South African museum are from the 19th century, when taxidermy followed a rather unique process. Jatti Bredekamp, chief executive of Iziko Museums explains…

    “Before the mid-twentieth century, taxidermy mounts were prepared by being soaked in arsenic and preserved from insect infestation through regular applications of DDT, both highly toxic poisons that retain their toxicity over time,” he said.
    Bredekamp said the horns were deliberately targeted in a carefully planned robbery, and might be destined for Asia, where ground rhino horns are a prized aphrodisiac.

    The theft is unfortunate, but hopefully a few poachers (or their supporters) get what they’ve got coming.
    More from Reuters
    Photo courtesy of Matt Field