Archives: 4/2008

John Kanzius, a businessman and radio technician diagnosed with leukemia, came up with what some call “the most promising breakthroughs in cancer.” His “radio wave machine” is discussed in the following segment from CBS’ 60 Minutes:


More from CBS: The Kanzius Machine: A Cancer Cure?…

6774sp1 Spiegelmer Technology
NOXXON Pharma AG, a company from Berlin, is trying to develop clinically useful aptamers of nucleic acids, a mirror image L-oligonucleotides branded as Spiegelmers®. (“spiegel” is mirror in German.) The company was just recently awarded a research grant from the Federal Ministry of Education and Research to further advance the firm’s promising technology.

A Spiegelmer® is a mirror-image oligonucleotide that can bind to a pharmacologically relevant target molecule in a manner conceptually similar to an antibody that recognizes an antigen. The mirror image configuration of the oligonucleotide confers tremendous stability in all biological environments, as naturally occurring nucleases cannot degrade Spiegelmers.
Identification of Spiegelmers involves screening of extremely large combinatorial libraries containing over 1015 different molecules. NOXXON’s technology combines the SELEX process (Systematic Evolution of Ligands by EXponential Enrichment) – the method to screen such a library – with chemical mirroring technology (see flash animation). Employing NOXXON’s technology Spiegelmers® can be rapidly generated against a wide variety of target molecules.
Unlike antibodies Spiegelmer are chemical entities unknown to nature and do not require complex biological production processes. Instead Spiegelmers can be synthesized in the laboratory using a process that is easily scalable. NOXXON has established optimized production and quality control methods…
Spiegelmers possess the high affinity binding characteristics of the best aptamers and antibodies in the low nanomolar and picomolar range, while defying enzymatic degradation that severely limits the utility of aptamers. Data indicate that Spiegelmers are stable in human plasma for over 60 hours at 37 °C.
Spiegelmers should not be confused with antisense RNAs in that they do not directly interfere with protein synthesis of their target molecules. They are designed to bind specifically to extracellular molecules, either a receptor or its ligand, similar to the behavior of a monoclonal antibody, aptamer or peptide. However, recent findings by NOXXON demonstrate that Spiegelmers are capable of entering cells and interfering with intracellular processes as well.

Product page: Spiegelmers technology…
Press release: NOXXON Receives Research Grant from the Federal Ministry of Education and Research (.pdf)…

45858re TONO PEN AVIA Tonometer Gets MDEA AwardTono-Pen Avia applanation tonometer, a device designed to diagnose glaucoma and other intraocular pressure disorders, is another winner of this year’s Medical Design Excellence Awards. Reichert Inc., a Depew, NY firm behind the device, explains the benefits of its hand-held instrument:

No Calibration
The TONO-PEN AVIA does not require daily calibration.
Accurate and Easy to Use
The TONO-PEN AVIA is designed to help eliminate operator error and functions in any position, making it ideal to use on all your patients, including those in beds or wheelchairs. Activated by the push of a button, the IOP measurement is displayed on two large, easy-to-read, LCD screens. Patients will appreciate the quick and gentle measurement process.
Intelligent
The TONO-PEN AVIA utilizes micro strain gauge technology and a 1.0mm transducer tip. The device displays the average of 10 independent readings along with a statistical confidence indicator, ensuring accurate, repeatable, and reliable tonometry results.
Versatile
The TONO-PEN AVIA tonometer features the same proven accuracy as the clinically trusted TONO-PEN XL, but with a more ergonomic design, four times longer lasting battery, and larger LCD screens. The proven reliability of Reichert’s applanation tonometers allows operators to take IOP measurements confidently anytime, anywhere, and in any position.

Product page: TONO-PEN AVIA Applanation Tonometer…
Press release: 33 Innovative Products Win Medical Design Excellence Awards…

Mini Dollar highres Worlds Smallest Spinal Cord Stimulator Approved in US, Europe
St. Jude Medical just announced that the company’s rechargeable, longest-lasting Eon Mini implantable neurostimulator has received approval from the FDA, as well as a CE Mark from the EU.

Even with its small size, the Eon Mini has the longest-lasting battery life of any rechargeable spinal cord stimulation (SCS) device in its class. It is the only small rechargeable neurostimulator to receive a 10-year battery longevity approval by the FDA. For patients this means the device should provide sustainable therapy and maintain a reasonable recharge interval for 10 years of use at high settings. The device’s battery longevity also may mean that patients require fewer battery replacement surgeries.

EonMini Red highres Worlds Smallest Spinal Cord Stimulator Approved in US, Europe

The Eon Mini also allows patients the freedom to comfortably recharge the device’s battery while taking a walk, cooking a meal or shopping because the charging system is fully portable. Additionally, Eon Mini has the greatest recommended implant depth of any small rechargeable SCS device, so the device can be placed more discreetly, potentially making it less noticeable.
In addition, the Eon Mini device features the following:

  • Enhanced microchip and software (NeuroDynamix™) technology that continuously selects the most efficient power management mode, preserving the battery’s capacity to deliver therapy.
  • Constant current circuitry that automatically adjusts power output to deliver consistent therapy over time.
  • Advanced programming capability that allows physicians to treat up to eight pain areas simultaneously to address complex pain patterns.
  • A 16-contact header that is compatible with all St. Jude Medical SCS leads, giving physicians more control in designing the system for optimal pain relief.
  • Product page: The Eon Neurostimulation System…
    Press release: St. Jude Medical Receives FDA and CE Mark Approvals for the World’s Smallest, Longest-Lasting Rechargeable Neurostimulator to Treat Chronic Pain…

    35232nv1 NovoFine Autocover, a Needle for Insulin InjectionThough not a new product, the NovoFine® Autocover® needle for insulin injection from Novo Nordisk is worth mentioning, primarily because it was just recognized at the eleventh annual Medical Design Excellence Awards (MDEA).

    NovoFine® Autocover® is designed to conceal the needle during injection and may therefore help diabetes patients overcome needle anxiety. As many as 10% of people with diabetes suffer from a fear of needles, to the point where they actually avoid injections.
    NovoFine® Autocover® has currently been launched in the US, UK, Spain, Italy, the Netherlands, Denmark, France and Ireland. It is used with the Novo Nordisk FlexPen® and other Novo Nordisk insulin injection devices.

    Product page: NovoFine® Autocover®…
    Press releases: Novo Nordisk wins design award for NovoFine® Autocover®…; 33 Innovative Products Win Medical Design Excellence Awards…

    heartstringsIII seal 01 us  HEARTSTRING III Proximal Seal System for CABGMAQUET Cardiovascular is releasing the newest model of the popular proximal anastomotic device for heart surgery, designed to offer a complete hemostatic seal without the need for an aortic side clamp. For those of you who are confused, HEARTSTRING now belongs to MAQUET Cardiovascular, after the firm acquired Boston Scientific’s Vascular Surgery and Cardiac Surgery divisions, which in turn included the products and services of Guidant Cardiac Surgery.

    This latest version of MAQUET’s innovative HEARTSTRING proximal seal technology allows surgeons to perform coronary artery bypass grafts without the use of a partial occlusion clamp during beating heart surgery.
    “We firmly believe that off-pump beating heart surgery results in better patient outcomes. The HEARTSTRING device provides a means to reduce aortic manipulation, a well-appreciated risk factor for adverse neurologic complications in coronary artery bypass,” said John D. Puskas M.D., Chief of Cardiac Surgery at Emory Crawford Long Hospital and Professor of Surgery. “With its unique features and improved delivery system, the new HEARTSTRING III system makes it easier for the cardiac surgeon to perform a clampless proximal anastomosis for either saphenous vein or radial artery conduits.”

    heartstringsIII loader 01 u HEARTSTRING III Proximal Seal System for CABG

    The HEARTSTRING III system features an improved seal loader and delivery device for fast, easy placement. Once deployed, it maintains a low compliant profile for optimal hemostasis at the anastomotic site. The HEARTSTRING III system enables surgeons to use their own hand-suturing technique for creating a proximal anastomosis with either venous or arterial grafts. With its elegant design and small operational footprint, there is no foreign material left inside the vessel after completion of the anastomosis. The Aortic Cutter makes a single, clean hole in the aorta for graft placement. The HEARTSTRING III system allows for maximum surgical flexibility. Surgeons have the option to perform distal or proximal grafts first and to use grafts of varying lengths, hooded grafts, and angled take-offs.

    Video showing the functionality of the system. (Windows Media)
    Product page: HEARTSTRING® III Proximal Seal System
    Press release: MAQUET Cardiovascular Launches HEARTSTRING III Proximal Seal System for Coronary Artery Bypass Graft Surgery

    4633wq Nanoparticles As Hearing AidsNanoBioMagnetics, Inc. of Edmond, Oklahoma has received a patent for using metallic nanoparticles as the main component for creating a hearing aid system.

    The patent, titled “Method and Apparatus for Improving Hearing,” is based on the use of magnetically responsive nanoparticles implanted in the organs of the middle ear to drive tissue vibrations in the amplification of sound. The technology was the first demonstration of the nanomechanical movement of tissue and operates in principle much like a typical commercial electromagnetic hearing aid. Development and validation was done during 2002 – 2004. The company now will move the technology through commercialization partnerships.
    Statistics of the National Institutes of Health indicate sensorineural hearing loss affects approximately 28 million Americans. The technology covered by today’s patent has the potential to move hearing aid systems to smaller and totally implantable hearing devices, achieving more favorable patient economics, performance and compliance.

    Press release (PDF): NanoBioMagnetics Announces Issuance of US Patent
    Patent application at USPTO…
    Company page: NanoBioMagnetics, Inc.
    (hat tip: The Engineer Online)

    4534dd1 The Single Tooth Anesthesia (STA) System
    Canon Communications’ Medical Design Excellence Awards (MDEA) are in. The first winning product that we want to profile is the Single Tooth Anesthesia (STA) System from Milestone Scientific, a Livingston, NJ company. Touted as a computerized local anesthesia injection system, the STA can “accommodate all standard 1.8 ml local anesthetic cartridges and a variety of luer lock needle sizes.”
    4534dd2 The Single Tooth Anesthesia (STA) SystemHere’s how the company profiles its device to dentists:

    The Single Tooth Anesthesia (STA™) System from Milestone Scientific is the first computer-controlled local dental anesthetic system where just one injection at a single tooth is all that’s needed to scientifically, safely and predictably ensure single-session injection precision. It’s even highly effective for multi-quadrant cases.
    STA is the only system of its kind with patented real-time visual and audible feedback technology, allowing you to easily obtain proper needle placement between the tooth and bone…
    STA increases your confidence administering the Block – proper technique prevents needle deflection – improving your ability to inject into the Block the first time!
    Single tooth anesthesia means that you get right to work – with faster onset – and your patients return to their routine without collateral numbing.
    "It’s the best shot I ever had" – "It’s the best shot I ever gave" that’s what you can expect to hear.
    Voted one of the practices "Best Investments" find out why STA dentists have happily packed away their needles and syringes.

    Press release: 33 Innovative Products Win Medical Design Excellence Awards…

    biomimetics A Survey of BiomimeticsThis month’s National Geographic magazine is featuring an article on the exciting field of Biomimetics, or the science of mimicking nature in the development of new materials and products. Of all the industries, medicine will probably be one of the biggest beneficiaries of future discoveries in this field.

    For all nature’s sophistication, many of its clever devices are made from simple materials like keratin, calcium carbonate, and silica, which nature manipulates into structures of fantastic complexity, strength, and toughness. The abalone, for example, makes its shell out of calcium carbonate, the same stuff as soft chalk. Yet by coaxing this material into walls of staggered, nanoscale bricks through a subtle play of proteins, it creates an armor as tough as Kevlar —3,000 times harder than chalk. Understanding the microscale and nanoscale structures responsible for a living material’s exceptional properties is critical to re-creating it synthetically. So today Andrew Parker had arranged to view the skin of a thorny devil museum specimen under a scanning electron microscope, hoping to find the hidden structures that allow it to absorb and channel water so effectively.
    With a microscopist at the helm, we soared over the surface of the thorny devil’s skin like a deep-space probe orbiting a distant planet, dipping down now and then at Parker’s request to explore some curious feature of the terrain. There seemed to be little of interest in the Matterhornlike macrostructure of an individual thorn, though Parker speculated that it might wick away heat from the lizard’s body or perhaps help capture the morning dew. Halfway down the thorn, however, he noticed a series of nodules set in rows, which seemed to grade down to a larger water-collection structure. Finally we dove into a crevasse at the base of the thorn and encountered a honeycomb-like field of indentations, each 25 microns across.
    "Ah-ha!" Parker exclaimed, like Sherlock Holmes alighting upon a clue. "This is clearly a superhydrophobic surface for channeling water between the scales." A subsequent examination of the thorny devil’s skin with an instrument called a micro-CT scanner confirmed his theory, revealing tiny capillaries between the scales evidently designed to guide water toward the lizard’s mouth. "I think we’ve pretty well cracked the thorny devil structure," he said. "We’re ready to make a prototype."

    Full article at National Geographic: Biomimetics: Design by Nature…