Archives: 1/2008

46343eyw1 Electronic Contact Lenses for Better Vision
Researchers at the University of Washington managed to embed an electronic circuit and LEDs directly into contact lenses, which seemed to look good on rabbit eyes. Though the circuit is not functional and the lights don’t light up, the development shows that future applications like direct video to the eye may indeed be possible.

The prototype device contains an electric circuit as well as red light-emitting diodes for a display, though it does not yet light up. The lenses were tested on rabbits for up to 20 minutes and the animals showed no adverse effects.
Ideally, installing or removing the bionic eye would be as easy as popping a contact lens in or out, and once installed the wearer would barely know the gadget was there, Parviz said. [Babak Parviz is a University of Washington assistant professor of electrical engineering --ed.]

46343eyw2 Electronic Contact Lenses for Better Vision

Building the lenses was a challenge because materials that are safe for use in the body, such as the flexible organic materials used in contact lenses, are delicate. Manufacturing electrical circuits, however, involves inorganic materials, scorching temperatures and toxic chemicals. Researchers built the circuits from layers of metal only a few nanometers thick, about one thousandth the width of a human hair, and constructed light-emitting diodes one third of a millimeter across. They then sprinkled the grayish powder of electrical components onto a sheet of flexible plastic. The shape of each tiny component dictates which piece it can attach to, a microfabrication technique known as self-assembly. Capillary forces — the same type of forces that make water move up a plant’s roots, and that cause the edge of a glass of water to curve upward — pull the pieces into position.
The prototype contact lens does not correct the wearer’s vision, but the technique could be used on a corrective lens, Parviz said. And all the gadgetry won’t obstruct a person’s view.
“There is a large area outside of the transparent part of the eye that we can use for placing instrumentation,” Parviz said. Future improvements will add wireless communication to and from the lens. The researchers hope to power the whole system using a combination of radio-frequency power and solar cells placed on the lens, Parviz said.

Press release: Contact lenses with circuits, lights a possible platform for superhuman vision

  • Hospital clown images ‘too scary’ … [BBC News]
  • Negative Studies of Depression Meds Remain Unpublished … [WSJ]
  • New Bacteria Strain Is Striking Gay Men … [NY Times]
  • New gene test for prostate cancer at hand … [Karolinska Institutet]
  • Chronic-pain treatment without side effects … [Nature]
  • Toxoplasma Infection Increases Risk of Schizophrenia, Study Suggests … [Johns Hopkins Children's Center]
  • Primer: making sense of T-cell memory … [Nature Clinical Practice Rheumatology]
  • New Chromosome Abnormality Linked to Autism Spectrum Disorders … [Children's Hospital Boston]
  • Common genetic variation in the type A endothelin-1 receptor is associated with ambulatory blood pressure: a family study … [Journal of Human Hypertension]
  • Vascular surgeons ask, what’s next for carotid artery stenting? [Elsevier]
  • Nature Publishing Group and Sermo Partner to Help Physicians Access, Interpret, and Contribute to Current Medical Research … [Sermo.com]
  • Canon Communications to Launch New Event for Drug and Medical Device Marketing … [Canon Communication]
  • CryoCor Files Patent Infringement Lawsuits Against CryoCath … [CryoCor]
  • St. Jude Medical Announces FDA and European CE Mark Approvals of Durata Defibrillation Lead … [St. Jude Medical]
  • RSB Spine, LLC Announces First Implantation of the InterPlate(TM) L for the Lumbar Spine … [ RSB Spine]
  • A good night’s sleep could improve long-term memory … [Medical Research Council UK]
  • Involuntary Rectal Exam in NY ER Leads to Lawsuit … [WSJ]
  • sterling screws Beef...Its Where Your Medical Implants Come From The next time you blow out your ACL, you may be surprised to learn that the surgeon won’t be using titanium screws, but rather bovine metatarsals.

    The most valuable parts of its cows are the inedible parts: pituitary glands, bones, heart muscles and hides. Medical companies covet them for making surgical glue, bone screws, collagen and artificial skin.
    As the engineers of the medical world, surgeons use various materials to rebuild the human body. For many years, reconstructive surgery has involved the use of metals like titanium in pins, screws and other parts. In recent years, however, surgeons have moved toward using biological tissue implants. Human tissue is the preferred material, but demand for human bone, cartilage and ligament outstrips the supply.
    “If you can use a xenograft — that is cow or pig bone — you can get all the bone you want,” said Farshid Guilak, director of the Orthopaedic Bioengineering Laboratory at Duke University.
    “The first thing we do is shape into rough-hewn shapes around the size and specification you might need,” Hartill said. “Then you do the fine machining. It’s actually a screw and it has a thread, so we use identical (cutting and milling) equipment to the titanium-screw manufacturers.”
    One popular product is the Sterling Interference Screws [manufactured by Regeneration Technologies -ed], shown above, which are made from bovine metatarsals, the small bones in and around the feet. They’re often used in reconstructive surgery such as repairing the torn anterior cruciate ligament that plagues many athletes.

    More from Wired
    Regeneration Technologies

    tiw99291%20%28300%20x%20206%29 Portable Device for Quick, Cheap Alzheimers ScreeningEarly screening for disabling neurological illnesses such as Alzheimer’s offers countless benefits to the booming elderly population.

    The Georgia Tech and Emory device, called DETECT, gives individuals a roughly ten-minute test designed to gauge reaction time and memory – functions that, when impaired, are associated with the earliest stages of Alzheimer’s disease. The test is a specially modified, shortened version of the traditional pen and paper test and could be given repeatedly by doctors to evaluate any changes in cognitive functions.
    “We really envision this to be part of the normal preventative care a patient receives from a general practitioner,” said Michelle LaPlaca, Ph.D., one of the creators of the device and an associate professor in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University. “It would be part of a regular preventative medicine exam much like a PSA test or EKG (electrocardiogram), serving as a cognitive impairment vital sign of sorts.”
    The portable test runs patients through a battery of visual and auditory stimuli such as pictures and words that assess cognitive abilities relative to age, gauging reaction time and memory capabilities. Its software can track cognitive capabilities – and decline – year to year during annual appointments. And because the device blocks outside sound and light from the patient’s environment, it can be administered in virtually any setting, providing more consistent results.
    Preliminary analysis of the first 100 patients of a 400-person clinical study being conducted at Emory’s Wesley Woods Center has shown that the 10-minute DETECT test has similar accuracy to the 90-minute “Gold Standard” pen and paper test.

    There are plans to commercialize the device by the end of this year.
    Spinoff company: Zenda Technologies
    Press Release

    collapsible chair Freedom   Collapsible Commode Chair
    When you’ve gotta go, you gotta go, and designer Julie Clyde thinks that portability is a long overdue trait in today’s commode market.

    Collapsible lightweight shower/commode chair, specifically designed for disabled people who travel and require a lighter, more compact alternitive to currently available products. The “Freedom” is the only one of its kind. This chair is designed with the aspiration to help the many people with disabilities gain more freedom and personal space which is so often compromised. With its innovative storage/ collapsibility it has potential to be used personally and in hospitals, nursing homes where minimal storage space is required. The simplicity of the quick release pins on the hub of the main wheel and also at the top of the castor wheels, means they can easily be removed and packs in on top of the collapsed commode frame in a carry case.

    Yanko Design

    Thanks to a cooperative effort between Mercy Health Centers and students from the University of Arkansas, hospital gift shops will be installing full integrated RFID scanners for maximum ease and efficiency. Hospitals may not be able to track surgical supplies in your gut yet with RFID tags, but at least your flowers and jujubes are never missed.

    “With the implementation of RFID technology, we’ll be bringing volunteer groups into the high tech world, along with a higher level of automation, security and inventory control,” Michelle Bass, director of compliance and customer relations at Mercy Health System of Northwest Arkansas, said. “We’re very excited about our healthcare transformation taking place, and are ensuring it touches every level of Mercy, right down to the gift shop.
    In addition to incorporating cutting-edge retail technology, the gift shop at the new campus will offer boutique-style items to customers. Available product lines will include Woodwick Candles, Camille Beckman lotions, See’s candy, Willow Tree collectibles and a large variety of nice baby items, among other items.

    Full Story
    (hat tip: Jay Parkinson)

    easy writer Easy Writing For The Disabled
    As any occupational therapist can attest to, children with disabilities often struggle to master essential fine motor skills like writing. Designer Oskar Daniel hopes that his unorthodox design may be the solution.

    You may not put much thought into it but it takes a symphony of small muscles in your hand to operate a pen/pencil. For some people this is beyond their ability so designer Oskar Daniel set out to create a pen the Easy Writer.
    wacom%20graphire%20bt Easy Writing For The DisabledA pen or graphite tip is inserted into a small hourglass shaped holder which provides all the support. The rubberized knob makes it easy to grip with your palm to move the pen. Effort is powered by the arm instead of the hand. It may not be the best solution since typing would be easier but there’s something personal about seeing your own writing.

    Personally, we’d like to see a digital version that integrates with a Wacom Graphire tablet, to digitize and resize the users handwriting.
    More at Yanko Design

    low field%20mri Weaker, Cheaper, Better MRIs
    Researchers at Los Alamos National Laboratory are experimenting with MRI just slightly stronger than the earth’s own magnetic field in hopes of developing cheaper, more accurate methods of detecting tumors.

    Most MRI machines have a magnetic field of about 1.5 teslas, strong enough to yank metal objects out of the hands of the unwary. Zotev’s machine, however, generates a magnetic field of only 46 microteslas, roughly the same strength as the Earth’s magnetic field.
    Researchers at Los Alamos National Laboratory have made what they say are the first images of a human brain using magnetic fields a hundred-thousandth the strength of conventional magnetic resonance imaging (MRI), paving the way for lower cost medical images that might be better at detecting tumors.
    Because it needs fewer costly magnets, a weak­magnetic-field MRI machine might cost as little as US $100 000, compared with $1 million or more for a standard MRI system, says Zotev. But perhaps the most exciting thing about low-field imagers is that they can also perform another imaging technique, magneto­encephalography (MEG), which, conveniently, also relies on SQUIDs. MEG measures the magnetic fields produced by brain activity and is used to study seizures. Putting the two imaging modes together could mean matching images of brain activity from MEG with images of brain structure from MRI, and it might make for more precise brain surgery.
    Low-field MRI has other advantages, says John Clarke, a physicist at the University of California, Berkeley, who uses a single-SQUID MRI device to image tissue samples. “I’m personally quite excited about the idea of imaging tumors” with low-field MRI, he says. The difference between cancerous and noncancerous tissue is subtle, particularly in breast and prostate tumors, and the high-field strengths used in conventional MRI can drown out the signal. But low-field MRI will be able to detect the differences, Clarke predicts. A low-field MRI might also allow for scans during surgical procedures such as biopsies, because the weaker magnetic field would not heat up or pull at the metal biopsy needle.

    Read on at IEEE Spectrum

    63435mor1 Morgellons Disease: A New Skin Infection? CDC Wants to Know
    The Centers for Disease Control and Prevention (CDC) is launching a study, in conjunction with Kaiser Permanente’s Northern California Division of Research, to investigate whether multiple reports of a strange skin disease, that some call Morgellons, are true. ABC News is planning to run a story tonight on “Nightline” (11:35 ET), and has released the following statement about its upcoming program:

    People with the condition, referred to as Morgellons disease, say they have fibers and other inorganic material growing out of their skin.
    “We earnestly want to learn more about this unexplained illness which impacts the lives of those who suffer from it,” said Dr. Michele Pearson, principal investigator leading the study for CDC, in a press release. “Those who suffer have questions, and we want to help them.”
    “We have a team of epidemiologists, laboratorians and pathologists to carry out the study,” Pearson said…
    In 2006, a number of Morgellons sufferers told ABC News in interviews that when they consulted doctors, they received diagnoses that they called wrong or dismissive. Brandi Koch, the wife of former Major League Baseball player Billy Koch, said that she felt as if she was living in a horror movie, claiming she had colored fibers coming out of her skin.
    Koch, of Clearwater Beach, Fla., said that her life was good until one day in the shower when she noticed something strange — tiny fibers running through her skin.
    “The fibers look like hair, and they’re different colors,” Koch said.
    Koch said she knows that what she experienced “sounds crazy,” but it’s true. “If I had a family member call me up and say, ‘I have this stuff,’ I’d say, ‘I’m sending a straitjacket over. You need some help,’” she said.

    63435mor2 Morgellons Disease: A New Skin Infection? CDC Wants to KnowFrom the CDC statement:

    The investigation may take 12 months or longer to complete. Initially investigators will identify and recruit participants and collect detailed information on participants’ symptoms and potential factors that may contribute to the condition. Later eligible participants will undergo detailed clinical evaluations, including a general medical examination, dermatologic examination, mental health examination, skin biopsies, and multiple blood tests.

    Press release: CDC To Launch Study on Unexplained Illness
    CDC: Unexplained Dermopathy (aka “Morgellons”) …
    The Morgellons Research Foundation (MRF) …
    Images @ Morgellons Research Foundation…
    Lots of fuzzy images at MorgellonsUSA.com …