Archives: 10/2007

46534leu1 Wireless EEG Powered by Body Heat
This autonomous electroencephalogram system, powered by body heat, is another interesting device developed by the IMEC, a Belgium/Netherlands nanotechnologies research center.
46534leu2 Wireless EEG Powered by Body HeatHere’s more about this prototype’s technology:

The entire system is wearable and integrated into a headband. The small size, low power consumption of only 0.8mW and autonomous operation increase the patient’s autonomy and quality of life. Potential applications are detection of imbalance between the two halves of the brain, detection of certain kinds of brain trauma and monitoring of brain activity.
The EEG system uses IMEC’s proprietary ultra-low power biopotential readout ASIC to extract high-quality EEG signals with micro-power consumption. A low-power digital signal-processing block encodes the extracted EEG data which is sent to a PC via a 2.4GHz wireless radio. The whole system consumes only 0.8mW.
The thermoelectric generator is mounted on the forehead and converts the heat flow between the skin and air into electrical power. The generator is composed of 10 thermoelectric units interconnected in a flexible way. At room temperature, the generated power is about 2-2.5mW or 0.03mW/cm2 which is the theoretical limit of power generation on human skin. Higher power generation would cause an uncomfortable sense of cold. The EEG system is operational in less than one minute after switching on the device.
Future research targets further reduction of the power consumption of the different system components including the radio and processor. Also, a semiconductor process for manufacturing thermopiles is under development. This will allow a significant reduction of the production cost.

IMEC: IMEC realizes wireless EEG system powered by body heat …

346234ecg A Wireless ECG PatchIMEC, a Belgium/Netherlands research center in nanoelectronics and nanotechnologies, has developed what it describes as a “wireless, flexible and stretchable” ECG patch for comfortable continuous cardiac monitoring:

The ECG patch is a hybrid system combining electronic assembly on a flexible Polyimide substrate and textile integration. This allows achieving flexibility and stretchability. Standard ECG electrodes are used for attachment to the body. The ECG patch can fit body curves and allows optimal, personalized, placement of the electrodes. It can therefore be used to monitor cardiac activity ‘on-the-move’ in daily-life conditions, thus opening new perspectives for cardiovascular disease management. Placed on the arm or on the leg, the same system can also be used to monitor muscle activity (EMG).
The core of the wireless ECG patch consists of a miniaturized wireless sensor node integrated on a flexible, Polyimide, substrate. It integrates IMEC’s proprietary single-channel ultra-low-power biopotential ASIC for the monitoring of the ECG signal. It also includes a commercial microprocessor enabling local digital signal processing, a 2.4GHz radio link and a miniaturized rechargeable Lithium-ion battery. The battery is placed under the electronic components to ensure the local rigidity required for long-term functioning of the electronic components. In addition, the sensor node features a fork-antenna and a snap-on connector (for connection to the electrode). The total size of the flexible core part is 60x20mm2. Two additional snap-on connectors are coupled to the central part with short conductive wires. The complete system is then integrated into textile to form the ECG patch. The use of very short wires and their integration into textile allows the minimization of an important source of artifacts due to wire movement.
The wireless ECG patch can work in continuous monitoring mode, in which the ECG – or EMG – data is continuously transmitted to the receiver (sample frequency between 250 and 1000Hz). For cases in which only heart rate information is required, the heart rate can be computed locally on the node and then sent over-air to the receiver. This allows drastic reduction of the use of the radio and hence increases the autonomy of the system. The embedded miniaturized rechargeable battery offers a capacity of 175mAh, which allows for an optimal autonomy of the system varying from one day in continuous monitoring to several days for simple heart rate monitoring. The signal is sent to a receiver connected to a PC or to a data-logger for later download on a computer.

IMEC realizes wireless, flexible and stretchable ECG patch for comfortable cardiac monitoring …
(hat tip: The Engineer)

Tara Parker-Pope, a health blogger at the New York Times, has compiled a list of websites that will fascinate your kids with the wonderful world of biology and medicine.

21534toil Ins and Outs

  • Report says drop weight to cut cancer… [Reuters]
  • Bush Official Heading to Europe on Health Study Trip … [WSJ]
  • The Beating Question for Medtronic’s Recall … [WSJ]
  • Personalized genomes go mainstream … [Nature]
  • New Brain Cells Listen Before They Talk … [Yale]
  • ISU technology detects single molecule of virus associated with cervical cancer … [Iowa State University]
  • University of Pittsburgh Cardiologists Identify New Gene Responsible for Sudden Cardiac Arrest … [University of Pittsburgh]
  • Economic motivation may affect how often some physicians order imaging studies … [MGH]
  • Study: Med school leaders largely tied to drug companies and device manufacturers … [AP]
  • Designing Medical Devices Requires a Pound of Flesh … [Wired]
  • Latest tests find the toxic metal in more products … [Consumer Reports]
  • Six-Pack Surgery: From Puffy to Buff … [WSJ]
  • World Toilet Summit conference opens in Delhi … [BBC News]
  • 32542ert Scientists Observe Evolution in the Nanoworld
    Investigators from the research groups of Dr. Klaus Kern at the Max Planck Institute for Solid State Research in Stuttgart (MPI) and of Mario Ruben at the Karlsruhe Institute of Technology (KIT) created a surface slime, composed of molecules with predetermined functions, and observed a fascinating self organization of these molecules into nanostructures. Scientists believe that their findings are a direct example, and a possible way, on how to create simple life forms. Furthermore, they believe that their nanostructures, reported in the Proceedings of the National Academy of Sciences, “also hold great promise as an efficient avenue to new catalysts, nanotechnologies, and surface applications.”

    … this observation of molecular organization at surfaces may lead to further insight of how simple, inanimate molecules can build up biological entities of increasing structural and functional complexity, such as membranes, cells, leaves, trees, etc. “The ability of molecules to selectively sort themselves in highly organized structures is a fundamental requirement for all molecular based systems, including biological organisms,” explains Prof. Dr. Klaus Kern, director of the Nanoscale Science Department at the MPI.
    Dr. Mario Ruben’s research team at KIT is responsible for designing molecules with built-in instructions, which when read out activate the self-selection process. He comments: “Spontaneous ordering from random mixtures only occurs when built-in instructions are carefully designed and sufficiently strong to initiate successful self-selection.”
    Scientists at the MPI directly observe the basic step of self-selection by imaging grid-like assemblies of molecules, which have sorted themselves by size. The features of the grid pattern are about one nanometer in size (0.000 000 001 meters), so small that they can only be imaged using state-of-the-art, ultra sensitive microscopy techniques. “Creating such miniscule architectures with features 50 000 times smaller than a hair is not a simple task,” according to Dr. Steven Tait of the MPI. “Carving these nanometer structures with current technology would be inefficient and extremely expensive. Our strategy is to utilize instructed building blocks which can arrange themselves into desired structures.”
    The molecules are placed on ultra-clean metal surfaces and heated gently to enable motion, sorting, and organization. “The molecule movement on the copper surface is restricted to two-dimensions, but is still efficient enough to allow mixing of the molecules. By placing the molecules on a surface, we have the enormous advantage of being able to use specialized microscopes to ‘see’ the nanometer scale structures of the molecular assemblies,” explains Alexander Langner, a graduate student at the MPI and first author of the study.

    Link: Evolution in the Nanoworld …

    76567mit Synthetic Genomics and Its Policy ImplicationsAfter 20 months of research and discussions, a group of scientists, ethicists and policy makers from J. Craig Venter Institute (JCVI), the Center for Strategic & International Studies (CSIS), and the Massachusetts Institute of Technology released the report called Synthetic Genomics: Options for Governance, which “outlines areas for interventions and policy options to help mitigate potential risks with this promising area of research.”
    From the press statement by the J. Craig Venter Institute:

    Synthetic genomics is a field of research in which scientists use chemically created pieces of DNA (called oligonucleotides or oligos) to design and assemble chromosomes, parts of chromosomes, genes and gene pathways. Scientists foresee many potential positive applications including new pharmaceuticals and biologically produced, green fuels. However, as with many technologies, there is the potential for misuse and accidents.
    The core group set out to analyze the state of the technology in synthetic genomics and to develop a comprehensive set of options for policy makers, researchers, and companies in the field. The report includes options that help to enhance biosecurity, foster laboratory safety, and protect the communities and environment outside of laboratories…
    The group identified three areas for policy intervention and outlined policy options for each intervention point. Drew Endy noted, “Our report draws upon the perspectives of many different stakeholders, including developers and users of DNA synthesis technology, as well as the biosecurity community. We hope that our efforts will help ongoing discussions of the responsible use of synthetic genomics techniques and tools.”
    The first set of options applies to firms that supply synthetic DNA, both those that supply gene- and genome length strands of DNA and those that supply much shorter oligonucleotides. This set includes the option, for example, that firms must use special software to screen orders for potentially harmful DNA.
    The second set of options is aimed at the oversight or regulation of DNA synthesizers and reagents used in synthesis. For example, owners of DNA synthesizers might be required to register their machines, or that licenses might be required in order to purchase specific chemicals needed to synthesize DNA.
    The final set of options is aimed exclusively at legitimate users of synthetic genomics technologies. The options cover both the education of users (e.g., modules in university courses that explicitly discuss the risks and best practices when using these new technologies) and prior review of experiments (for example, expanding the roles of institutional biosafety committees to review a broader range of “risky” experiments).

    Here’s the full report to read, or you can send it to the printer:


    For criticism of the report, head on to the ETC Group
    JCVI’s press release: New Policy Report Outlines Options for Governance of Synthetic Genomics …
    Report: Synthetic Genomics: Options for Governance …
    Flashbacks: Medgadget synthetic biology archives…

    Solviva PR Solviva™ Family of BiomaterialsBelgian chemical and pharmaceutical firm Solvay S.A.‘s Advanced Polymers unit has announced the launch of its Solviva biomaterials line, designed for use in implantable medical devices.

    Solviva Biomaterials are comprised of:

  • Zeniva™ PEEK (polyetheretherketone) — one of the most chemically resistant plastics available, exhibiting high strength and stiffness along with excellent toughness and fatigue resistance
  • Proniva™ SRP (self-reinforced polyphenylene) — the stiffest and strongest unreinforced thermoplastic available, offering exceptional chemical resistance and hardness
  • Veriva™ PPSU (polyphenylsulfone) — offers unsurpassed toughness combined with transparency and excellent chemical resistance
  • Eviva™ PSU (polysulfone) — offers practical toughness in a strong, transparent polymer
  • According to a press release, Solvay Advanced Polymers is currently in active product trials for its line of Solviva
    biomaterials with several medical device manufacturers including Zimmer Medical.
    Solvay Advanced Polymers …
    Press release: Solvay Advanced Polymers launches Solviva™ Biomaterials available for use in implantable medical devices (.pdf)…

    34534eve1 FulFil Adjustable Face Implant Goes Strong for Two Years
    Evera Medical, a Foster City, CA manufacturer of the facial saline-adjustable implant FulFil, is reporting that more than 670 of the devices have been implanted in the last two years with “no serious adverse events.” The company markets its implants under two names, with FulFil™ being an international product, which was issued the European CE Mark in April for “augmentation of facial soft tissue, including lip augmentation,” and in the US the device is called VeraFil™, and it was cleared by the FDA for “augmentation and reconstruction in and around the orbit of the eye,” according to Evera Medical.
    34534eve2 FulFil Adjustable Face Implant Goes Strong for Two YearsWe have not seen this device before, so here’s a quick look at the company’s technology:

    The FulFil implant is made up of a very thin compliant and porous membrane. This membrane is made of ePTFE, which is 50 microns in thickness and surrounds a silicone balloon that is filled with normal saline. The pores within the ePTFE membrane allow limited tissue incorporation without a fibrotic response often causing painful and rigid encapsulation of the implant. A patented ‘slip plane’ technology allows full movement between the silicone balloon and the outer ePTFE layer, thereby contributing to discreet and limited tissue growth.
    This novel technology is ideal for adding volume to the lips as flexibility and full animation of the mouth is maintained. Contrary to other implants made of thicker synthetic material, the lips remain full, soft and natural looking. Volume is added with normal saline to achieve the desired appearance.

    Product page: FulFil implant …

    durex last longer 3 Too Quick on the Draw?  Durex Wants You!
    Now that baseball is over, what is the average male supposed to concentrate on to prolong their “time at the office?” Have no fears fellas, the fine folks at Durex have just released a line of promotional products just for you. Unfortunately, the details are a bit sketchy, but it looks like Durex created these climax postponing pillowcases to promote their new Performa Condoms which have built-in anesthetic cream to delay the inevitable.
    Enjoy!
    (hat tip: Core77 Design Blog, Direct Daily)