Archives: 3/2007

Some scientists in Australia have developed a computer program that takes a photo of a woman’s face, and ranks her “beauty” on a scale from 1 to 10 with a +/- 1.5 point margin of error. They believe that the software can be used in cosmetic surgery to determine whether or not a surgery could actually make someone look more beautiful. Here’s a snippet of an article from The Age on the software:

Their invention uses facial measurements, related to ratios and images of models, actors and some 200 women from around the world.
To develop their system, they divided the face into measurements such as the distance between the top of the face and the chin and between the eyes.
They assembled 215 images of women of different ages, levels of attractiveness and ethnic backgrounds, including photographs of Claudia Schiffer (pictured), Kate Moss and Catherine Zeta-Jones.
The images were shown to a mixed gender, multi-racial panel of 50 volunteers who gave each face a rating of between one and 10.
They found while participants sometimes varied greatly in the ratings they gave, overall there was significant agreement over what was an attractive face.
Next they analysed the facial measurements of the women in the test images as well as the ratios between the measurements.
By looking for correlations, they were able to determine the features common in beautiful women, and develop software that combined this with facial-analysis technology.
Dr Piccardi said one danger of the software was that it could fall into the hands of adolescents or others sensitive about their looks and harm their self-image.

This kind of software brings up all kinds of questions. In terms of medicine, it is always helpful to be able to quantify something that is very subjective. On the other hand, is this really a problem right now in the medical field? It doesn’t take a computer to tell a doctor if he botched a nose job. Without a doubt this software will “fall into the wrong hands” eventually. Could it possibly be used against doctors who did a perfectly ok job, but whose patient is upset that the computer says they fell from an 8 to a 7?
It’s too bad that the program is only for women. But then again, who needs computers to tell men they’re ugly? That’s what wives/girlfriends are for.
Read the article here
(Hat Tip: Engadget)

245632gees PS3s Folding at Home Project Could Find a Cure for Alzheimers
Alright gamers, it’s not everyday that you get the opportunity to outpace the entire digital community in the race to find a cure for diseases like Alzheimer’s, Huntington’s, Parkinson’s and Cancer. But Stanford’s Folding@Home project is about to change all of that.

Since 2000, Folding@Home (FAH) has led to a major jump in the capabilities of molecular simulation. By joining together hundreds of thousands of PCs throughout the world, calculations which were previously considered impossible have now become routine. FAH has targeted the study of of protein folding and protein folding disease, and numerous scientific advances have come from the project.
Now in 2006, we are looking forward to another major advance in capabilities. This advance utilizes the new Cell processor in Sony’s PLAYSTATION 3 (PS3) to achieve performance previously only possible on supercomputers. With this new technology (as well as new advances with GPUs), we will likely be able to attain performance on the 100 gigaflop scale per computer. With about 10,000 such machines, we would be able to achieve performance on the petaflop scale. With software from Sony, the PlayStation 3 will now be able to contribute to the Folding@Home project, pushing Folding@Home a major step forward.
Our goal is to apply this new technology to push Folding@Home into a new level of capabilities, applying our simulations to further study of protein folding and related diseases, including Alzheimer’s Disease, Huntington’s Disease, and certain forms of cancer. With these computational advances, coupled with new simulation methodologies to harness the new techniques, we will be able to address questions previously considered impossible to tackle computationally, and make even greater impacts on our knowledge of folding and folding related diseases.
ADVANCED FEATURES FOR THE PS3
The PS3 client will also support some advanced visualization features. While the Cell microprocessor does most of the calculation processing of the simulation, the graphic chip of the PLAYSTATION 3 system (the RSX) displays the actual folding process in real-time using new technologies such as HDR and ISO surface rendering. It is possible to navigate the 3D space of the molecule using the interactive controller of the PS3, allowing us to look at the protein from different angles in real-time. For a preview of a prototype of the GUI for the PS3 client, check one of these videos ( 355K avi, 866K avi , 6MB avi , 6MB avi– more videos and formats to come).

If the boys over at Gizmodo did their math right, 2 million PlayStation3 users will be able to contribute a mind boggling 30 gigaflops of “folding power” each!! To put that number into perspective, the average PC can barely eek out 1 gigaflop of folding power and that roughly 830 PS3′s are doing the equivalent work of 322,000 other active computers.
Remember to join the Medgadget Folding@Home team once you set up that PS3. We would even recommend getting one for gaming and one for folding.
Folding@Home for the PS3
Gizmodo has more here and here . . .
YouTube videos for Cure@PS3

lost%20in%20space NC State Researchers Create Robots to Invade Our Bloodstream Remember a time when robots were slow, awkward, and not in our blood? Our children won’t.

North Carolina State University scientists have figured out a method to supply microscopic devices with enough energy to not only allow them to propel themselves through liquid – a difficult function in its own right – but also to perform some other functions, like emitting light.
The findings have the potential to lead to “smart devices” or “microrobots” that can interact with their environment and perform certain tasks – like moving, sensing other materials, including biological materials, lighting up and spinning – on their own.
The millimeter-sized devices can be controlled externally and have the potential to be powered by radio waves.
The research is published in the February 2007 edition of Nature Materials.
The researchers – Dr. Orlin Velev, associate professor of chemical and biomolecular engineering at NC State and principal investigator of the project, Suk Tai Chang, a graduate student at NC State and their colleagues Dr. Dimiter Petsev from the University of New Mexico and Dr. Vesselin Paunov from the University of Hull in the United Kingdom – took various types of millimeter-sized diodes, or electronic devices containing two electrodes, and placed them in a liquid-filled dish with two external electrodes placed on the outer edges of the dish. The researchers applied alternating electric fields to the electrodes at the outer edges of the dish, which provided energy for the diodes to move on their own. The diodes absorb the external field energy and convert it into motion in a process called electro-osmosis.
velev diodes sm NC State Researchers Create Robots to Invade Our Bloodstream
“There are very few ways to make microdevices move around, especially in liquid, because as you scale down the size of the device, viscosity plays a more important role . It’s somewhat like swimming in molasses,” Velev said. “We have shown how to provide devices with external energy from electrical fields, which the devices convert into directional motion that can be controlled electronically.”
But the researchers’ self-propelling microdevices do more than just move through liquid. The paper describes how the voltage induced within the devices’ electrodes can be used to perform other functions, like emitting light or spinning around. Velev and his colleagues also controlled the speed at which some diodes move by directing a laser beam at the tiny devices, proving further that the devices can sense their environment and act in certain ways.
This sensing function could be very important, Velev says, if it can be used to separate biological molecules, such as looking for a particular protein and analyzing it. He also envisions future tiny devices that can move through biological fluids for applications like drug delivery or microsurgery.
Now that they’ve proven the concept, Velev and his team are working to create better microfluidic devices where the flow of microscopic volumes of liquid can be steered and controlled by electronic diode pumps, valves and mixers. Microfluidic devices with diode pumps can achieve better analysis of biological samples, assist in development of drugs or perform other biotechnology operations.

Press Release . . .
(hat tip: Engadget)

Watch out medical students, the next time you have to practice breaking bad news to standardized patients, you may be hooked up to skin sensors to measure the quality of your empathy.

“To our knowledge, this is the first study of the physiology of shared emotions during live psychotherapy sessions,” said Carl Marci, the Harvard psychiatrist who led the study. “We were pleased to find evidence for a biological basis of empathic connections. Our results suggest that therapists perceived as being more empathic have more positive emotional experiences in common with patients.”
Marci said research has shown that lack of empathy is the biggest predictor of a poor outcome for patients in psychotherapy. Still, empathy isn’t everything, he said.
“Empathy is important, but it’s not the whole story,” Marci said. “It’s not sufficient to determine the outcome of therapy.”
In a study published in the February issue of the Journal of Nervous and Mental Disease, Merci and his colleagues described using a combination of skin sensors and videotapes viewed by neutral observers to measure empathy. They said their results suggest a nervous network for empathy and emotional response that is “implicated in the ability to take another’s emotional perspective.”

PhysOrg . . .
Abstract . . .

  • Trojan horse strategy defeats drug-resistant bacteria
    [University of Washington]
  • Largest-ever study of its kind proves no mouth-to-mouth, continuous chest compressions better for out-of-hospital cardiac arrest
    [The University of Arizona Health Sciences Center]
  • Researchers create artificial enzyme that mimics the body’s internal engine
    [Stanford]
  • Liveblog: PS3′s Folding at Home is Coming
    [Gizmodo]
  • NOT FUNNY: Stanford study finds no conclusive benefit from treating kleptomania
    [Stanford]
  • Report: Binge Drinking Rises at Colleges
    [AP]
  • Interspecies Sex: Evolution’s Hidden Secret?
    [National Geographic News]
  • 26645reer A Microjet System for Intradermal Drug DeliveryResearchers from UC Santa Barbara, UC Berkley and in collaboration with California based StrataGent Life Sciences, developed a novel pulsed microject system engineered for protein drug delivery without any needle pain. Here’s an excerpt from UCSB:

    The researchers felt that the pain and bruising caused by previously-developed jet injectors was caused by the deep penetration of jets into the skin, creating negative reactions of nerves and capillaries. The pulsed mircrojets engineered by the researchers combine high velocity (more than 100 meters per second) with very small jet diameters (between 50 and 100 micrometers), delivering only 2 to 15 nanoliters of liquid drug at a time. The research showed that the pulsed microjet system could be used to effectively deliver drugs for local and systemic applications without using needles.
    “The microjet system delivers precise doses into superficial skin layers, thereby mitigating pain,” says Samir Mitragotri, a professor of chemical engineering at UCSB and a lead author of the paper. The system was designed as an alternative to the macro-scale systems that had been causing pain and bruising. “We realized that we had to find a way to stop the jets from going deep into the skin,” says Mitragotri. “Speeding the delivery, combined with using extremely small jet diameters and less liquid per pulsation, was shown to be more effective.”

    Link @ UC Santa Barbara
    Flashback: Vitajet™ 3

    5435 Force Sensor for Cerebral Aneurysm TreatmentIn a joint effort, NTN corporation and Prof. Hideo Fujimoto, of the graduate school of Nagoya Institute of Technology, have developed a force sensing system for cerebral aneurysm treatment. Some details from NTN:

    The system measures and displays any minute force from the fingertips of a surgeon (operator) manipulating a very thin wire, which is only 0.3mm in diameter, passed through a catheter in cerebral arteries during minimally invasive treatment of aneurysms.
    Minimally invasive operations are becoming more prevalent in the medical field because they use a much smaller incision than that in the past to perform the same operation. This reduces trauma of the patient along with the recovery time. An aneurysm is a bulge, or balloon, in a blood vessel normally occurring near the brain. If left untreated, these aneurysms can burst, causing subarachnoid hemorrhaging. Coil Embolization is a procedure used to occlude the cerebral aneurysm, preventing its rupture. In this operation, a catheter is inserted through a vessel near the groin and a small micro catheter is worked to the location of the aneurysm. It is necessary for the surgical operator to work this very thin wire with minute force in order not to rupture the aneurysm or blood vessel by mistake. Then platinum coils are deployed into the aneurysm filling it from within and thus preventing blood from entering the aneurysm itself.

    Link to NTN product page…

    Nueron A Brain On/Off Switch
    MIT Technology Review reports that researchers at the Stanford Medical Center developed a novel method that switches different parts of the brain on and off. This research is an effort to provide a tool that one day can be used as a treatment option for people with different psychiatric problems. Here’s a scoop from the article:

    While scientists know something about the chemical imbalances underlying depression, it’s still unclear exactly which cells, or networks of cells, are responsible for it. In order to identify the circuits involved in such diseases, scientists must be able to turn neurons on and off. Standard methods, such as electrodes that activate neurons with jolts of electricity, are not precise enough for this task, so Deisseroth, postdoc Ed Boyden (now an assistant professor at MIT; see “Engineering the Brain”), and graduate student Feng Zhang developed a neural controller that can activate specific sets of neurons.
    They adapted a protein from a green alga to act as an “on switch” that neurons can be genetically engineered to produce (see “Artificially Firing Neurons,” TR35, September/October 2006). When the neuron is exposed to light, the protein triggers electrical activity within the cell that spreads to the next neuron in the circuit. Researchers can thus use light to activate certain neurons and look for specific responses–a twitch of a muscle, increased energy, or a wave of activity in a different part of the brain.
    Deisseroth is using this genetic light switch to study the biological basis of depression. Working with a group of rats that show symptoms similar to those seen in depressed humans, researchers in his lab have inserted the switch into neurons in different brain areas implicated in depression. They then use an optical fiber to shine light onto those cells, looking for activity patterns that alleviate the symptoms. Deisseroth says the findings should help scientists develop better antidepressants: if they know exactly which cells to target, they can look for molecules or delivery systems that affect only those cells. “Prozac goes to all the circuits in the brain, rather than just the relevant ones,” he says. “That’s part of the reason it has so many side effects.”

    Link

    42562mega New Color Display for Information Systems in the Medical Field
    Here are the details on a new color display from Siemens aimed at the medical community:

    The SCD 19110 offers high luminance of up to 300 cd/m2 (candelas per square meter) and an outstanding contrast ratio of 1000:1. The 19″ display is suitable for hospital information systems (HIS) and radiology information systems (RIS) as well as for review of medical images.
    The MVA (multi-domain vertical alignment) panel technology used on the SCD 19110 ensures a fast response time for gray-scale images and a wide viewing angle. This allows several persons to view the contents of the display simultaneously. The 1-megapixel display can be used universally in hospitals and permits applications in the radiological field.
    Like all displays from Siemens A&D, the new device is precalibrated in the factory. It has three preset look-up tables (LUTs) via which the display can be automatically adapted to the application in question. Simple selection of the suitable LUT increases flexibility for the user. The monitor parameters of the LUT comply with the DICOM (Digital Imaging and Communications in Medicine) standard. This means the display is also suitable for review of medical images.

    More from Siemens…