Archives: 1/2007

5247poo NanoMission™: Nano Gaming
NanoMission™, a computer game that takes players through the world of nanoscience, is now available in beta.

London-based computer games development studio PlayGen and global nanotechnology consultancy Cientifica have announced the availability of the playable demo of NanoMission™ from www.nanomission.org
NanoMission™ is a cutting edge engaging learning experience which educates players about basic concepts in nanoscience through real world practical applications from microelectronics to drug delivery. The demo of the first module, nanomedicine, compels the player to select a suitable vehicle to deliver an anti cancer compound, and then navigate through the bloodstream to the site of the tumour, while avoiding the bodies’ natural defence mechanisms.
“Nanomedicine is an area that has caused a great deal of excitement but has also been tragically misrepresented”, commented Cientifica CEO Tim Harper. “the nanomedicie challenge within NanoMission illustrates how nanoscientists are learning from nature to produce viable drug delivery mechanisms for today’s market”
Professor Mark Welland FRS of the University of Cambridge added, “It is extremely important that as nanotechnology is introduced into an increasing range of products the real benefits are understood by all. This game is a great example of how the positive message of nanotechnology can be disseminated to schools.”
PlayGen are relying on partnerships with organisations such as the Royal Society of Chemistry to ensure the game meets the educational community requirements. The National Physical Laboratory is the latest member of the game’s scientific advisory board, bringing world class expertise in the challenges of measurement at the nanoscale and use of virtual worlds for science communication and knowledge transfer.
“Working with the scientific community has enabled us to develop NanoMission based on real science rather than science fiction”, notes Kam Memarzia, PlayGen’s managing director adding “We firmly believe computer games have a far greater role to play in today’s society, especially in promoting learning & understanding the real world around us.”


Press release
For more info and to download, visit here
(hat tip: MTB Europe)

eeg cap EEG Authentication: Because Fingerprints are so 90sScientists are always trying to come up with new security technologies. Have people been lopping off fingers and pulling out eyeballs so frequently as to necessitate some kind of “improvement”? That could be what the researchers at the Centre for Research and Technology Hellas, in Greece are thinking. Their product is the electroencephalogram authentication system. Here’s a little bit on the technology from newscientisttech.com:

Since an individual’s brain activity is determined by the unique pattern of neural pathway in their brain, the same technique can be used for identification, Tzovaras says. “It could be a very good security control,” he told New Scientist.
The authentication system requires a user to have EEG measurements taken beforehand with further measurements for each authentication test. This is done via a removable cap, which communicates wirelessly with a computer that analyses the data gathered. The cap has fewer electrodes than are normally used for EEG measurements, but can still provide enough information for authentication, according to Tzovaras.
Currently users must sit quietly with their eyes shut during each test. “We ask them to close their eyes and not speak”,” Tzovaras says, which provides “a much clearer picture”.
The result of each authentication test is compared with the user’s pre-recorded measurements, using signal-processing algorithms. These algorithms can be tuned to different security levels.

One might think that a system this complicated must be pretty accurate:

A separate group, led by Rafal Wardzinski at Warsaw University of Technology in Poland, is also working on EEG biometrics. In testing, this group found that the method could identify subjects with 88% accuracy.

Fingerprint scan accuracy is between 95-98%, and an iris scan is about 99.8% accurate. So why even bother?
Bonus question: Do you know what movie this quote is from?

My voice is my passport; verify me.

Read the article here
(Via: Engadget)

987645oo Copying Wrinkles for Better ProstheticsDomenic Eggbeer, a PhD student at the National Center for Product Design & Development Research in UK, hopes to apply the technology of rapid prototyping to improve the quality of prosthetics and to slash production times.

Mass production techniques have transformed the world and made advanced technology cheaply available in all kinds of areas. Rapid prototyping (aka 3D printing) could make these techniques available areas mass production won’t reach.
That’s important because economies of scale mean that some areas of life haven’t benefited from technology as much as they could. If demand is small, it’s simply too expensive, and just not worth it to mass produce. Assistive technologies that can improve the quality of life of disabled people, for example, are not a big enough market for mass production. But rapid prototyping could change all that.
“Today’s techniques have pretty much remained unchanged for forty years,” he told me. Skilled artists work with wax to sculpt a prosthesis, which is then used as a mould to make a finished piece of silicone. Skin texture is one of the most important features needed to make a prosthesis look realistic – it’s added to the wax using toothbrushes, orange peel or gauze. But the whole process takes 2-3 days with the patient having to be present for much of it.
Eggbeer has been testing a rapid prototyping machine for printing realistic skin instead. A close-up photo of their skin, or an imprint of it, can be used to instruct a 3D printer to produce the same texture in wax over a large area. The photo above shows some of the results.
Eggbeer’s goal is to use a few photos and perhaps 3D scans of the patient to quickly make a near-complete wax model of a prosthetic. “Instead of them sitting there for a whole day, they would only need come in for a final fitting, and adjustments,” he says.

Full article at the New Scientist Blog . . .

2735laa Ancient Book of Herbs Used in the War on BacteriaThe history of medicine is a rich and fascinating topic which has very little relevance to non-geeks… until now! Researchers from the Mayo Clinic have published a paper in the BMJ, which used an ancient herbal text as a guide to finding novel drugs. Apparently they stumbled onto an antibiotic that can wipe out some of the more stubborn strains of super bacterias. Here’s more from the press release:

A unique Mayo Clinic collaboration has revived the healing wisdom of Pacific Island cultures by testing a therapeutic plant extract described in a 17th century Dutch herbal text for its anti-bacterial properties. Early results show that extracts from the Atun tree effectively control bacteria that can cause diarrhea, as claimed by naturalist Georg Eberhard Rumpf, circa 1650. He documented his traditional healing methods in the book Ambonese Herbal.
The Mayo Clinic-led team’s report appears in the Dec. 23 edition of The British Medical Journal… In their report, Mayo Clinic researchers demonstrate the feasibility of using sophisticated data mining techniques on historical texts to identify new drugs.
The study provides a creative new model for drug discovery. It integrates nontraditional, ancient medical information with advanced technologies to identify promising natural products to investigate as drugs for new and better therapies.
“Natural products are invaluable sources of healing agents — consider, for example, that aspirin derived originally from willow bark, and the molecular basis of the anti-cancer chemotherapeutic agent Taxol™ was derived from the bark of the Pacific yew tree. So it’s not so far-fetched to think that the contributions of an ancient text and insights from traditional medicine really may impact modern public health,” explains Brent Bauer, M.D., director of the Mayo Clinic Complementary and Integrative Medicine Program.
For thousands of years, people around the world have lived intimately with botanical healing agents and evolved effective healing traditions. “Our work shows just how much we can learn from them. But to make the most of what is fast becoming lost knowledge, we have to respect, preserve and work with traditional healing cultures,” adds Eric Buenz, Ph.D., researcher for Minnesota-based BioSciential, LLC.
Rumpf referred to himself as Rumphius, in the Latinized scientific manner of the day. Rumphius was a German-born naturalist who worked for the Dutch East Indies Company. His book is an account of the herbal healing traditions on the Indonesian island of Ambon. Rumphius’ description of Atun kernels’ therapeutic properties is what modern medicine calls “antimotility agents,” they stop diarrhea. Writes Rumphius: “… these same kernels … will halt all kinds of diarrhea, but very suddenly, forcefully and powerfully, so that one should use them with care in dysentery cases, because that illness or affliction should not be halted too quickly; and some considered this medicament a great secret, and relied on it completely.”

Press release
Searching historical herbal texts for potential new drugs. BMJ 2006;333:1314-1315.
More from the New York Times

096989dd Take 2 Shots and Have Your Liver Call Me in the Morning
What do you buy the alcoholic who has everything? No, not a new liver. But the next best thing would be a Korean cellphone that [magically] monitors your liver enzymes and knows when to call your doctor. We’ll wait for the next generation model that will actually start the admission order for us.

Telecoms Korea has an attention grabbing post today about a mobile phone which can diagnose liver conditions.
“The Bionano Research Team of the Korea Research Institute of Bioscience and Biotechnology developed a bio sensor to measure GOT (Glutamine Oxaloacetic Transaminase) and GPT (Glutamine Pyruvic Transaminase) in blood and linked the sensor to a mobile phone. The result can also be transmitted to hospitals, said the research team.”

(hat tip: Gizmodo via NewLaunches via EngadgetMobile via Textually)

9832trauma1 The TraumaTransfer™
Medgadget has learned that IMT International Trade AG, a Swiss company, is planning to introduce its TraumaTransfer™ device at the Trauma & Critical Care show in Las Vegas in March 2007.
Here’s how the company presents its trauma board:

What is TraumaTransfer™?
TraumaTransfer™ is designed for fast and safe immobilisation and transferring of trauma-patients intrahospital.
What are the advantages of TraumaTransfer™?
TraumaTransfer™ allows you to eliminate several cumbersome and potentially dangerous lifts of the traumapatient. Therefore it is safer and more comfortable for the patient and easier for the staff.
9832trauma2 The TraumaTransfer™TraumaTransfer™ is optimized for x-ray and CT and leaves no artefacts in the pictures like vacuum-mattresses do.
Due to the pressure-relieving material, the risk for pressure-injuries is minimized.
For whom should it be used?
All trauma patients, even a slightly injured patient in need of x-ray or CT should be placed on the TraumaTransfer™. Patients with cerebral aneurysm or AVM will also benefit from being placed on the TraumaTransfer™.

Product brochure
Company site

8932acuf The AcuFocus ACI 7000™: Presbyopic Correction Technology
Bausch & Lomb has announced that the company made an equity investment in AcuFocus, Inc., a private firm in Irvine, California, and the designer of the ACI 7000, a corneal inlay for presbyopic correction:

The AcuFocus ACI 7000™ is designed to treat presbyopia, a condition which affects more than 50 million people in the United States. Presbyopia, a part of the normal aging process, reduces the ability of the eye to focus on near objects. Traditionally, most people with presbyopia have had to use reading glasses to improve their near vision. The AcuFocus corneal inlay is designed to treat presbyopia in all patients, including those who have had cataract surgery, and reduce their dependence on reading glasses.
The ACI 7000 corneal inlay is implanted in the cornea under a LASIK flap in a simple outpatient procedure. The device incorporates technology that increases the patient’s depth of field, thereby improving near vision. The ACI 7000 has been designed to maintain normal corneal physiology and corneal health. The procedure does not involve tissue removal nor does it permanently alter the cornea, so pre-implant vision can be restored if the inlay is removed.
Recent studies have demonstrated that the ACI 7000 improves near vision in patients who previously didn’t require vision correction (emmetropes) as well as those who have had LASIK surgery. Trials are being conducted to study the ACI 7000 in patients with intraocular lenses.
“Current surgical presbyopic solutions involve compromises that can negatively affect the quality of vision for many patients. The ACI 7000 corneal inlay is designed to remove those compromises through a safe and simple procedure,” said Daniel S. Durrie, MD., Principal Investigator. “Moreover, pre-clinical studies performed outside of the United States show excellent early results and high patient satisfaction.”

Bausch & Lomb press release
AcuFocus company’s site
Product details (.pdf)

9380colla Veritas® Collagen Matrix for Prevention of Surgical AdhesionsSynovis Life Technologies, Inc (St. Paul, MN) is reporting that its Veritas® Collagen Matrix technology is now indicated for prevention of post-operative adhesions. The company’s remodelable collagen material, on the market since 2000, has been used for a variety of applications, from gastric bypass and thoracic surgeries to pelvic floor reconstructions.
The press release
Veritas® Tissue technology page

08967alz Another Genetic Clue for Alzheimers
Howard Hughes Medical Institute (HHMI) is reporting that a group from the University of Toronto has located what seems to be a new gene linked to the most common form of Alzheimer’s disease.

In an advance online publication in Nature Genetics on January 14, 2007, St George-Hyslop and colleagues connected the gene to the disease in six different groups of people, although they did not pinpoint the exact genetic mutations in SORL1 responsible for Alzheimer’s. In their studies, the researchers used databases that include genetic information about people with and without Alzheimer’s disease. More than 6,800 individuals–45.8 percent of them affected with the disease–were included in the analysis, which is considered a large data set in the field, said St George-Hyslop.
“We looked for variations of SORL1 in nine different groups of people and found those variations to be associated with an increased risk of Alzheimer’s in six of them,” St George-Hyslop said. “That implies that SORL1 is not the only cause of Alzheimer’s, but it’s one of several. Some people with the disease will have a SORL1-related cause, and some won’t…”
After linking SORL1 to late-onset Alzheimer’s, the team investigated the gene’s function. Using cell culture studies, they discovered that decreasing the amount of SORL1 increased cells’ production of amyloid-beta, a toxic fragment of another protein that destroys neurons. Production of amyloid-beta is the key event in the progression of Alzheimer’s disease.
Amyloid-beta is made when cells improperly break down a protein called amyloid precursor protein (APP). Previous research had revealed that APP is subjected to a sequence of cellular events that either properly recycles APP or shunts it into cellular structures called endosomes, where it is chopped into amyloid-beta. Researchers had identified several genes involved in this cellular sorting process. St George Hyslop and his team reasoned that inherited defects in some of these proteins might cause more APP to be shunted into endosomes, causing more amyloid-beta to be made, thereby increasing risk for Alzheimer’s. When the team investigated these genes, only SORL1 was associated with an increased risk of Alzheimer’s.
“What we have now are three independent sets of observations, all implicating the SORL1 gene in Alzheimer’s disease,” said St George-Hyslop. “We started with an observation from pathologists, showing reduced SORL1 protein levels in the brains of patients with Alzheimer’s. Then we have the observation by us and other groups that if you reduce SORL1 expression–in either cell cultures or mice–you get an increase in the production of amyloid-beta. Now we can add our new observation that variants of the SORL1 gene are associated with an increased risk of Alzheimer’s.”

Press release
Picture caption: The green arrows track re-entry of APP from the cell surface when SORL1 is present. The red arrows show that, when SORL1 is absent, more APP moves into domains such as the late endosome/lysosome, where the black arrows show how it is subsequently cut by two enzymes, beta-secretase (BACE1) and gamma-secretase (PS1 y-sec), generating the neurotoxic amyloid beta-peptide (A&946;).