Archives: 2006

4574sav1 Savvycheck: DIY Yeast Diagnosis
Savvycheck is a new at-home product for women to diagnose yeast infection. Currently sold only in Switzerland, Scandinavia, and Israel, the polyclonal antibodies test is a product of Savyon Diagnostics, an Israeli company.

Early feedback indicates that the new test is a welcome addition to the world of women’s health. “The response was very positive,” says Dr. Michael Dan, Professor of Internal Medicine at Tel Aviv University who was involved in the clinical trials for the test. “With this new kit, a woman can not only treat herself, but can do it appropriately, by being able to diagnose herself by simple means. This kit is an important step forward.”
4574sav2 Savvycheck: DIY Yeast DiagnosisSimplicity is one of the Savvycheck’s main advantages. The kit is composed of a sampling swab and disposable detection device. After a woman takes a sample from herself, she inserts the swab into the device. From there, the kit uses what’s known as lateral-flow technology – the same process used in many pregnancy tests. As the antigens contained in the vaginal sample travel down the test strip, they react with a complex containing anti-Candida antibodies, and move towards a control line and a test line. If the control line turns blue, the test is working. If the test line turns blue, the woman has a yeast infection.
Tests have shown a 100% concordance between women performing the tests on themselves and doctors performing the tests. The accuracy rate is over 90%.

More
Product page

987643hhi HydrAlert DeviceMedgadget has learned that an MIT medical device startup Hemetrics is developing a glucometer-like monitor of hydration.
From the company’s proposal that was submitted to MIT:

Hemetrics is developing a unique handheld product, HydrAlert, for inexpensively ($800 per unit), rapidly (6 seconds) and accurately (99%) putting a number on dehydration, making it easier to recognize and treat, and greatly reducing the costs from a missed diagnosis…
Measurement of sodium ion concentration in blood is a gold standard for detecting dehydration and its opposing malady, hyponatremia (overhydration). Blood sodium ion concentration is measured in a droplet of blood applied to a specially coated test strip and then inserted into the HydrAlert device. The test strip chemistry is proprietary and protected by provisional patent filings. The successfully proven diabetes business model will be used to detect something new: dehydration.

YouTube company video presentation
Company website

547655tt2 Growing Heart Muscle Goes 3D
Growing 3-dimensional heart tissue in just four days at the Artificial Heart Laboratory sounds like the stuff of science fiction, but it’s reality for Ravi K. Birla, Ph.D at the University of Michigan.

It looks, contracts and responds almost like natural heart muscle — even though it was grown in the lab. And it brings scientists another step closer to the goal of creating replacement parts for damaged human hearts, or eventually growing an entirely new heart from just a spoonful of loose heart cells.
This week, University of Michigan researchers are reporting significant progress in growing bioengineered heart muscle, or BEHM, with organized cells, capable of generating pulsating forces and reacting to stimulation more like real muscle than ever before.
The three-dimensional tissue was grown using an innovative technique that is faster than others that have been tried in recent years, but still yields tissue with significantly better properties. The approach uses a fibrin gel to support rat cardiac cells temporarily, before the fibrin breaks down as the cells organize into tissue.
The U-M team details its achievement in a new paper published online in the Journal of Biomedical Materials Research Part A.
And while BEHM is still years away from use as a human heart treatment, or as a testing ground for new cardiovascular drugs, the U-M researchers say their results should help accelerate progress toward those goals. U-M is applying for patent protection on the development and is actively looking for a corporate partner to help bring the technology to market.
Ravi K. Birla, Ph.D., of the Artificial Heart Laboratory in U-M’s Section of Cardiac Surgery and the U-M Cardiovascular Center, led the research team.
“Many different approaches to growing heart muscle tissue from cells are being tried around the world, and we’re pursuing several avenues in our laboratory,” says Birla. “But from these results we can say that utilizing a fibrin hydrogel yields a product that is ready within a few days, that spontaneously organizes and begins to contract with a significant and measurable force, and that responds appropriately to external factors such as calcium.”
The new paper actually compares two different ways of using fibrin gel as a basis for creating BEHM: layering on top of the gel, and embedding within it. In the end, the layering approach produced a more cohesive tissue that contracted with more force — a key finding because embedding has been seen as the more promising technique.

Read more here . . .

Dr. Palter from docinthemachine.com has a couple of interesting posts about the amazing medical advances that we owe to overwhelming military funding. Unfortunately, a particularly promising project known as the Trauma Pod is in danger of losing its funding.
Doc in the Machine quotes Dr. Satava’s description of the Trauma pod:

Like many revolutionary ideas, science fiction imagines what might be possible and it takes decades for hard science to catch up. Such is the case for Trauma Pod, a new capability and a new challenging research project for pre-hospital or far forward battlefield casualty care. Concepts of Trauma Pod can be traced back to the 1957 science fiction book “Starship Troopers” by Robert Heinlein, in which a self contained casualty “cocoon” was sent automatically from the spaceship directly to the wounded soldier on the battlefield. The casualty was placed inside this cocoon or pod, which was imagined to be a combination intensive care unit (ICU) and operating room (OR), capable of completely rescuing and, if necessary, operating upon a wounded soldier while being returned safely to the spaceship. As fantastic as that might have seemed, we are well over half way there, with systems that are currently deployed in Iraq and Afghanistan (and in clinical trials in select U.S. civilian trauma centers) and future systems to ultimately realize the full potential as so clearly articulated by Heinlein

The first of three videos illustrate how the Trauma pod would function if allowed to be fully developed.


To view the remaining videos, including both the prototype and the currently deployed product, head on over to Dr. Palter’s blog.

8765789woo Ultrastrong Carbon Nanotube MusclesRay Baughman, director of the Nanotech Institute at the University of Texas at Dallas, recently presented his research on the development of ‘artificial muscles’ that could someday be used in prosthetic limbs or possibly even microscale machines for use in the human body.

By spinning carbon nanotubes into yarn a fraction of the width of a human hair, researchers have developed artificial muscles that exert 100 times the force, per area, of natural muscle. This is according to Ray Baughman, director of the Nanotech Institute at the University of Texas at Dallas, who presented the research in Boston last week at the Materials Research Society conference.
Artificial muscles–actuators based on such materials as certain types of metals and polymers that shrink, grow, or change shape–are useful for prosthetic limbs, microscale machines, and robots. “Our biggest problem right now [in developing artificial muscles] is [that] the level of force being generated is not high,” says Yoseph Bar-Cohen, senior research scientist at NASA’s Jet Propulsion Laboratory, in Pasadena, CA. “Carbon nanotubes potentially can create enormous force.”
In Baughman’s latest work, done in collaboration with John Madden at the University of British Columbia, the researchers made actuators out of carbon-nanotube yarns. The yarns are created by first growing densely packed nanotubes, each about 100 micrometers long. The carbon nanotubes are then gathered from a portion of this field and spun together into long, thin threads. The nanotube yarn can be just 2 percent of the width of a hair–not even visible–but upwards of a meter long. According to Baughman, spinning these threads was “like hauling in a fish with an invisible line.” In his conference presentation, he described yarns that could support loads 150 times greater than nanotube papers could.

Read the full article at MIT’s Technology Review . . .

condom viag Groundbreaking Research Brings Nothing but ShameDisturbing new findings from a two-year study by the Indian Council of Medical Research, and reported by the BBC:

A survey of more than 1,000 men in India has concluded that condoms made according to international sizes are too large for a majority of Indian men.

“It’s not size, it’s what you do with it that matters,” he said. [Sunil Mehra, the former editor of the Indian version of men's magazine Maxim --ed.]
“From our population, the evidence is Indians are doing pretty well.”

Link at the BBC

63573faas Lab on a Chip Does Rapid Analysis of Breast MilkA team of researchers from UC Davis has done some interesting research into the biochemistry of human milk, using a specialized lab-on-a-chip technology by Agilent.
From UC Davis press release:

Oligosaccharides are sugar-like molecules that are the third-largest solid component of breast milk, after lactose and lipids. More than 200 oligosaccharides have been identified in milk, but there has been no way to measure their presence in an individual sample in a single test or run. They do not have direct nutritional value, and their role in development is not clear.
A recent study published online in the Journal of Agricultural and Food Chemistry detailed the successful use of two analytical tools to identify oligosaccharides in samples from five women in single runs. The tools were a “glycan chip” developed by Agilent specifically for this purpose, and a time-of-flight mass spectrometer used to characterize each oligosaccharide by determining its molecular mass to a precision of two parts per million.
The researchers found large variations between women in the total numbers and abundance of different oligosaccharides, with the total number per individual varying from 33 to 124. Only a few oligosaccharides were common to all subjects.
The combination of techniques has enabled a more complete understanding of these complex oligosaccharides, said Carlito Lebrilla, professor of chemistry at UC Davis and lead author on the paper. The techniques could be extended to other glycan structures, with medical and therapeutic applications, he said.
The new technique paves the way for further research into oligosaccharide function in human development, said co-author Rudi Grimm, worldwide proteomics and metabolomics market development manager with Agilent’s Life Sciences and Chemical Analysis (LSCA) group.

Link @ UC Davis
Article at the MIT’s Tech Review
Read more about the technology used in the study in Agilent’s press release
Product page

76544ass1 Kevlar like Dental CompositesDr. Vistasp Karbhari, a professor of structural engineering at UC San Diego, has quadrupled the strength of dental composites, thanks to a material similar to kevlar:

Vistasp Karbhari, a professor of structural engineering at UC San Diego, has developed fiber-reinforced polymer composites as strong, lightweight materials for aerospace, automotive, civil and marine applications, so he thought, “If they work so well in highway bridges, why not dental bridges?”
In a paper scheduled for publication in Dental Materials, Karbhari and Howard Strassler, a professor and director of Operative Dentistry at the University of Maryland Dental School, report the results of detailed engineering tests on dental composites containing glass fibers as well as the type of polyethylene fibers used in bullet-proof vests.
76544ass Kevlar like Dental CompositesKarbhari and Strassler found that the toughness of fiber-reinforced dental materials depends on the type and orientation of the fiber used. Their report, available at the Dental Materials website, shows that braided polyethylene fibers performed the best, boosting toughness by up to 433 percent compared to the composite alone…
The three products tested were a 3-millimeter-wide ribbon of unidirectional glass fibers, a 3-millimeter-wide ribbon of polyethylene fibers woven in a figure-8 stop-stitch leno-weave, and a 4-millimeter wide ribbon of polyethylene fibers woven in a biaxial braid. The resistance to breakage and various measures of toughness of the three preparations were compared to the dental composite alone.

Link

754745teeg Math to Improve Robotic SurgeryJohns Hopkins computer scientists in collaboration with surgeons are developing new mathematical models to improve the safety and efficiency of robotic surgery:

The project, supported by a three-year National Science Foundation grant, has yielded promising early results in modeling suturing work. The researchers performed the suturing with the help of a robotic surgical device, which recorded the movements and made them available for computer analysis.
“Surgery is a skilled activity, and it has a structure that can be taught and acquired,” said Gregory D. Hager, a professor of computer science in the university’s Whiting School of Engineering and principal investigator on the project. “We can think of that structure as the language of surgery.’ To develop mathematical models for this language, we’re borrowing techniques from speech recognition technology and applying them to motion recognition and skills assessment.”
Complicated surgical tasks, Hager said, unfold in a series of steps that resemble the way that words, sentences and paragraphs are used to convey language. “In speech recognition research, we break these down to their most basic sounds, called phonemes,” he said. “Following that example, our team wants to break surgical procedures down to simple gestures that can be represented mathematically by computer software.”
With that information in hand, the computer scientists hope to be able to recognize when a surgical task is being performed well and also to identify which movements can lead to operating room problems. Just as a speech recognition program might call attention to poor pronunciation or improper syntax, the system being developed by Hager’s team might identify surgical movements that are imprecise or too time-consuming.
But to get to that point, computers first must become fluent in the “language” of surgery. This will require computers to absorb data concerning the best ways to complete surgical tasks. As a first step, the researchers have begun collecting data recorded by Intuitive Surgical’s da Vinci Surgical Systems. These systems allow a surgeon, seated at a computer workstation, to guide robotic tools to perform minimally invasive procedures involving the heart, the prostate and other organs. Although only a tiny fraction of hospital operations involve the da Vinci, the device’s value to Hager’s team is that all of the robot’s surgical movements can be digitally recorded and processed. In a paper presented at the Medical Image Computing and Computer-Assisted Intervention Conference in October 2005, Hager’s team announced that it had developed a way to use data from the da Vinci to mathematically model surgical tasks such as suturing, a key first step in deciphering the language of surgery.

Full story @ Johns Hopkins…
Flashbacks: da Vinci Robot Surgery System; da Vinci Robot Surgery System in Action