Archives: 7/2006

Remember UK’s first beating heart transplant surgery made possible by TransMedics Organ Care System we reported last month? Well now that pioneering medical technology, a warm blood perfusion technology device, is on display at the Science Museum in London.
2006 2924 TransMedics in the Science Museum24 Hour Museum reports:

Pioneering medical technology set to revolutionise the way we carry out transplants will be on display at the Science Museum for National Transplant Week, which runs from Monday 10th – Saturday 15th July 2006.
The equipment – on temporary loan to the museum from its designers, TransMedics – enabled surgeons at Papworth Hospital to carry out the UK’s first beating heart transplant on 22nd May 2006.
Now, visitors to the Science Museum’s science and technology gallery, Antenna, will be able to see this life-saving medical apparatus firsthand, as well as amazing footage of a heart pumping in the apparatus’ chamber.
Natasha Waterson, Antenna Exhibition Developer said: “Right now, some organs are wasted because they can’t be transported and transplanted in time. A heart can only be stored for around 4-6 hours before it becomes unusable and it’s hard for medical teams to match a suitable patient and operate in time.”
“This new equipment from TransMedics can keep donor hearts alive for up to twelve hours, allowing medical teams to minimise the risk of organ rejection and up the success rate of transplants, which is good news for the 8,000 UK citizens who are currently on transplant waiting lists.”
The technology is currently being trialled at Papworth Hospital and works much like a portable life support system for individual organs, and is an innovative mix of exiting organ donor technology and new medical science.
5351254 TransMedics in the Science MuseumA heart is placed within a sterile chamber and then revived. Blood is sampled and the heart tested using ultrasound. Monitors track vital signs and provide important information for surgical teams assessing the heart for transplant. Pumps maintain a pulse-like flow of blood and nutrients to the heart stop it from deteriorating and becoming too damaged for a successful transplant.

For more on the technology, visit Trasmedics..
For the Museum, visit 24HourMuseum

MIT’s Technology Review features an interview with Drew Endy, an assistant professor of biological engineering at MIT, about the security concerns of synthetic biology and about efforts of scientists to prevent terrorists from acquiring the know-how of this emerging field. Link
Medgadget search: Synthetic Biology

9813759as Nanotech Surfaces for Ortho ImplantsBiomed engineers from Brown University came up with a novel type of surface for implants, one that discourages bacterial infestation:

Thomas Webster, an associate professor of engineering at Brown, led the research. Results are published in the Journal of Biomedical Materials Research.
“We’ve found a method of coating implants that discourages bacteria growth,” Webster said, “and it does so significantly. The hope is that this technique will lead to safer, longer-lasting implants…”
Webster, along with former Purdue University colleagues Gabriel Colon and Brian Ward, knew that abrading or coating implants to produce microscopic bumps, which create a sand-papery surface, aid in bone growth. This helps anchor the implant in the body and extends its life. Some artificial joints now sport these microstructured surfaces.
But the team wondered if smaller peaks and craters–ones that measure on the nanometer scale–would work even better. And how would bacteria react? So they experimented.
The engineers chose zinc and titanium oxides as their materials. Zinc oxide is a well-known antimicrobial agent. Titanium oxide, strong and light, is a commonly used in implants. Engineers took nanoparticles of these ceramics and pressed them into dime-sized discs. They took microparticles of these same materials and made more discs. Discs with nanostructured surfaces had bumps that measured only .023 microns in diameter. Discs with microstructured surfaces had bumps that measured about 5 microns in diameter. Under a microscope, the surface differences are extreme; the nanostructured discs look like saw-toothed mountains, the microstructured discs look like smooth plateaus.
The engineers put S. epidermidis on the discs and waited an hour. Then they counted the bacteria. The results were dramatic. Microstructured zinc oxide discs were host to 1,000 times more bacteria than the nanostructured zinc oxide discs. Similar, but less striking, results were duplicated on titanium oxide discs.
The engineers conducted similar experiments with bone-forming cells and found that twice as many of these cells grew and formed bone on nanostructured discs. Other indicators of healthy bone growth, such as collagen synthesis, were also stronger with nanostructured discs.
“Surface area seems to be key,” Webster said. “With the nanostructured surfaces we created, surface area increased by 25 to 35 percent. We think that this additional area, along with the unique surface energetics of these nanomaterials, gave bone-forming cells more places to adhere. But with bacteria, increased surface area may work the other way, exposing the bugs to more of the germ-fighting properties of the zinc oxide.”

Link

3214521ra First Nanoscale pH Meter ReportedHere’s an interesting development in applying nanoscience for diagnostic purposes. And in this case it is for diagnostic intracellular purposes. From the Rice University press office:

Using unique nanoparticles that convert laser light into useful information, Rice University scientists have created the world’s first nano-sized pH meter.
The discovery, which appears online this week in the journal Nano Letters, present s biologists with the first potential means of measuring accurate pH changes over a wide pH range in real-time inside living tissue and cells.
“Almost every biologist I speak with comes up with one or two things they’d like to measure with this,” said lead researcher Naomi Halas, the Stanley C. Moore Professor of Electrical and Computer Engineering, professor of chemistry and director of Rice’s Laboratory for Nanophotonics (LANP).
For example, pH may be useful in determining whether or not some cancer tumors are malignant. With current methods, a piece of the tumor would need to be physically removed via biopsy – a painful and invasive procedure – and visually evaluated under a microscope. Halas said LANP’s new nano-pH meter could be used instead as an “optical biopsy” to measure the pH inside the tumor with nothing more invasive than an injection.
Halas’s LANP team created the pH sensor using nanoshells, optically tuned nanoparticles invented by Halas. Each nanoshell contains a tiny core of non-conducting silica that’s covered by a thin shell of metal, usually gold. Many times smaller than living cells, nanoshells can be produced with great precision and the metal shells can be tuned to absorb or scatter specific wavelengths of light.
To form the pH sensor, Halas’ team coated the nanoshells with pH-sensitive molecules called paramercaptobenzoic acid, or pMBA. When placed in solutions of varying acidity and illuminated, the nanoshell-molecule device provides small but easily detectable changes in the properties of the scattered light that, when “decoded,” can be used to determine the pH of the nanodevice’s local environment to remarkably high accuracy. Inspired by techniques normally applied to image recognition, the team formulated an efficient statistical learning procedure to produce the device output, achieving an average accuracy of 0.1 pH units.

Make no mistake about it: such technology is urgently needed. Being able to know intracellular acid-base balance for a specific organ or a whole body will open all sorts of novel treatment strategies, especially in the critically ill.
The press release

German investigators have demonstrated that sperm cells, derived from embryonic stem cells, have a reproductive potential.
From BBC News:

Professor Karim Nayernia and colleagues at the Georg-August University in Göttingen, Germany, took stem cells from a mouse embryo that was only a few days old and grew these cells in the laboratory.
Using a specialised sorting instrument they were able to isolate some stem cells that had begun to develop as sperm.
They encouraged these early-stage sperm cells, known as spermatogonial stem cells, to grow into adult sperm cells and then injected some of these into female mouse eggs.
The fertilised eggs grew and were successfully transplanted into female mice and produced seven babies.

Link

13251451so Quantum Effect to Power Artificial Muscles?
Quantum physics research done at Ohio State University on solitons, particles that behave like self-reinforcing solitary waves, might have implications for the development of artificial muscles (and possibly other technologies) for humans and robots:

Li [Ju Li, assistant professor of materials science and engineering at Ohio State -ed.] explained that each soliton is made up of an electron surrounded by other particles called phonons. Just as a photon is a particle of light energy, a phonon is a particle of vibrational energy.
The new study suggests that the electron inside a soliton can attain different energy states, just like the electron in a hydrogen atom…
The soliton’s quantum mechanical properties — including these newly discovered energy states — are important because they affect how the particle carries a charge through organic materials such as conducting polymers at the molecular level.
“These extra electronic states will have an effect — we just don’t know right now if it will be for better or worse,” he said.
Li and his longtime collaborators from MIT published their findings in a recent issue of the Proceedings of the National Academy of Sciences (PNAS).
The name “soliton” is short for “solitary wave.” Though scientists often treat particles such as electrons as waves, soliton waves are different. Ordinary electron waves spread out and diminish over time, and soliton waves don’t.
“It’s like when you make a ripple in water — it quickly spreads and disappears,” Li said. “But a soliton is a strange kind of object. Once it is made, it maintains its character for a long time.”
In fiber optics, normal light waves gradually flatten out; unless the signal is boosted periodically, it disappears. In contrast, solitonic light waves retain their structure and keep going without assistance. Some telecommunication companies have exploited that fact by using solitons to cheaply send signals over long distances.
Before solitons can be fully exploited in a wider range of applications, scientists must learn more about their basic properties, Li said. He’s especially interested in how solitons carry a charge through conducting polymers, which consist of long, skinny chains of molecules.
The tiny chains are practically one-dimensional, and this calls some strange physics into play, Li said.
In their PNAS paper, Li and MIT colleagues Xi Lin, Clemens Forst, and Sidney Yip describe a detailed calculation of what happens to solitons at a quantum-mechanical level as they travel along a chain of the organic polymer polyacetylene…
Because polymer chains tend to bend and twist as solitons pass through them, scientists have wondered whether solitons could be used to power artificial muscles for high-tech robots and devices to aid human mobility. Such muscles would be made of organic polymers, and flex in response to light or electrochemical stimulation.
“If fully understood, solitons may also be harnessed to drive molecular motors in nanotechnology,” Li said.

Link

89316350ed Rub It UpHere’s an explosive piece of news. Futura Medical plc, a Guildford, Surrey, UK company, announced that it has “developed a highly efficient and proprietary delivery system for the absorption of active molecules through the skin. This delivery system is used in a gel form for MED2002, the Company’s topical treatment for men with erectile dysfunction (ED) currently undergoing late stage clinical trials.” What this means for the commoner, is that the company promises to deliver a nitroglycerin rub for you know what, to get a strong and unitary result.

MED2002 is based on the active compound GTN within a patented gel delivery system. GTN is a potent vasodilator and has been used for the treatment of angina and associated cardio-vascular defects for more than 40 years, where it has been determined to be a safe and effective drug with a known side-effect profile.
MED2002 is applied to the glans area of the penis with a single dose applicator. It has been designed to deliver an effective, rapid-onset, locally active dose with a low systemic uptake which will help to reduce unwanted side effects and minimize the potential for adverse interaction with other centrally acting drugs that may also be taken concomitantly by the patient, especially PDE5 inhibitors such as Viagra™, Cialis™ or Levitra™.
This is a less invasive method of application compared with other treatments and is consistent with sexual foreplay. The GTN is absorbed into the penile blood system and is converted to nitric oxide having the effect of relaxing muscles surrounding the corpus cavernosa and dilating the penile arteries. This allows the corpus cavernosa to engorge with blood and, following sexual stimulation, a natural erection occurs.
MED2002 is expected to become the world’s first non-prescription pharmaceutical treatment for men with ED. By being available from pharmacies without the need for a doctor’s prescription, MED2002 will be aimed at satisfying a large unmet demand from men with ED.

So far Futura Medical seems to be mum about the possible effect of nitroglycerin on the receiving party, as it is likely to be highly absorbed through mucosa (or right palmar dermis.) It is also not clear to us how the TNT rub will behave once real sparks start to fly.
Product page
Politically correct coverage at BBC News
Flashbacks: For full armamentarium see: HarmonySystem for Sex Without (Physical) Pain ; The ‘Viagra’ Condom; ViagraRing: Always Within Reach

UPC lg And I Dont Gotta Go Right NowHaving trouble controlling “the urge?” Is all your furniture covered in protective sheets of plastic? The Urgent PC Neuromodulation System from Uroplasty Inc., recently approved by the FDA, may be just what you need! The device works by stimulating the tibial nerve. From their website:

The Urgent PC System provides:
Sacral neuromodulation via the tibial nerve, delivered in simple, 30- minute outpatient sessions.
Cost-effectiveness throughout treatment program.
Effective treatment, even when conventional therapy has failed.
Ease of use for the clinician.
A low-risk treatment option for patients with minimal side-effects (reported side-effects include redness or discomfort at the treatment site).
In the treatment of Overactive Bladder:
Documented success rates of 60 – 80%.
Statistically significant reductions in daytime voiding frequency, nighttime voiding frequency and leakage episodes.
In the treatment of Faecal Incontinence:
78% of patients achieved a long-term improvement in faecal incontinence.

We’re so excited we could wet our pants with glee… but we can’t, because we’ve been neuromodulated.
Check out Uroplasty’s website here

India’s Central Drugs Standard Control Organization has issued new rules pertaining to all medical devices to be manufactured or sold in India…

The guidelines, which were issued by India’s Central Drugs Standard Control Organization (CDSCO), give manufacturers 60 days to obtain a license for medical devices they already manufacture in India. The current devices manufactured such as cardiac stents, drug eluting stents, catheters and orthopedic implants can be sold for up to six months until an application is approved or rejected.
Registration fees of $1,500 per manufacturing premise will be levied on device manufacturers with a fee of $1,000 per single device. This $1,000 fee would not be applicable of the device only varies in size or shape without any change in the material method of use.

The original article doesn’t elaborate as to the nature of the approval process. Whether this will require the stringent standards of the US FDA is unclear. Attempts to locate information on the CDSCO homepage proved fruitless.