Archives: 6/2006

glucon2 Glucon Reports Positive ResultsAccording to an article at the Globes [online], the Israeli company Glucon has presented good clinical results at the American Diabetes Association’s 66th Scientific Sessions. Company’s prototype noninvasive glucometer was shown “by a clinical study to be as precise as invasive blood sugar measurement devices.”
Glucon’s photoacoustics-based technology explained:

Photoacoustics involves ultrasonic waves created by the absorption of light. These ultrasound waves are generated by illuminating the tissue with laser pulses at several selected wavelengths. Analysis of the acoustic signals can map the depth profile of the absorbance of light in the tissue.
Glucon uses Photoacoustics to map the influence of the glucose on the optical properties of the blood inside blood vessels. The acoustics element is used for the localization of the measured volume inside a blood vessel, as well as removing the influence of the outer layers of the skin. The optics element provides the specificity to glucose by using several light wavelengths.

77463413 Glucon Reports Positive Results
Company’s website
Flashback: Glucon: Blood Sugar Magic; Glucone: noninvasive blood glucose

5314534 Novel Nanomaterial for Diagnostic DevicesInspired by a beetle from the Namib Desert that has adopted a mechanism to collect water from the morning fog, a group of scientists from MIT came up with a novel material:

When that fog rolls in, the Namib Desert beetle is ready with a moisture-collection system exquisitely adapted to its desert habitat. Inspired by this dime-sized beetle, MIT researchers have produced a new material that can capture and control tiny amounts of water.
The material combines a superhydrophobic (water-repelling) surface with superhydrophilic (water-attracting) bumps that trap water droplets and control water flow. The work was published in the online version of Nano Letters on Tuesday, May 2.
Potential applications for the new material include harvesting water, making a lab on a chip (for diagnostics and DNA screening) and creating microfluidic devices and cooling devices, according to lead researchers Robert Cohen, the St. Laurent Professor of Chemical Engineering, and Michael Rubner, the TDK Professor of Polymer Materials Science and Engineering.
The U.S. military has also expressed interest in using the material as a self-decontaminating surface that could channel and collect harmful substances.
The researchers got their inspiration after reading a 2001 article in Nature describing the Namib Desert beetle’s moisture-collection strategy. Scientists had already learned to copy the water-repellent lotus leaf, and the desert beetle shell seemed like another good candidate for “bio-mimicry.”
“If you sat at your desk and tried to just think of ways to do things, it would take a very long time,” Cohen said. “Once you see these things in action, it’s obvious what you have to do.”
The desert beetle has evolved to take perfect advantage of the tiny amount of water available in the desert. The fog that drifts over the Namib Desert is so light that normal condensation can’t take place, so “you need something specially designed to hold and collect that condensation,” Rubner said.
When fog blows horizontally across the surface of the beetle’s back, tiny water droplets, 15 to 20 microns, or millionths of a meter, in diameter, start to accumulate on top of bumps on its back.
The bumps, which attract water, are surrounded by waxy water-repelling channels. “That allows small amounts of moisture in the air to start to collect on the tops of the hydrophilic bumps, and it grows into bigger and bigger droplets,” Rubner said. “When it gets large, it overcomes the pinning force that holds it and rolls down into the beetle’s mouth for a fresh drink of water.”
To create a material with the same abilities, the researchers manipulated two characteristics — roughness and nanoporosity (spongelike capability on a nanometer, or billionths of a meter, scale).
By repeatedly dipping glass or plastic substrates into solutions of charged polymer chains dissolved in water, the researchers can control the surface texture of the material. Each time the substrate is dipped into solution, another layer of charged polymer coats the surface, adding texture and making the material more porous. Silica nanoparticles are then added to create an even rougher texture that helps trap water droplets.
The material is then coated with a Teflon-like substance, making it superhydrophobic. Once that water-repellent layer is laid down, layers of charged polymers and nanoparticles can be added in certain areas, using a properly formulated water/alcohol solvent mixture, thereby creating a superhydrophilic pattern. The researchers can manipulate the technique to create any kind of pattern they want.

The press release

patientsniffer goto SPOT NOSED: A Hi Tech Nose For Disease DetectionThe Discovery Channel is presenting a special on SPOT-NOSED, an e-nose project reported by us back in May.
Here’s their teaser:

The mechanical sniffer, currently undergoing development and testing as part of a project called SPOT-NOSED, could dramatically change how doctors diagnose illness.
The technology behind the device was inspired by the human nose, but its effectiveness is comparable to more sensitive animal noses.
“The human nose is not especially well suited for odor recognition, as compared to the noses of dogs or rats,” said Oscar Ruiz, who is working on the project.
Ruiz, a professor in the Department of Electronics at the University of Barcelona, Spain, added, “There are some groups in the world that have trained dogs to diagnose some diseases like melanoma or prostate cancer in urine.”
He explained to Discovery News that the sniffing device could do something similar, only it would use bioelectric sensors.
The gadget consists of a layer of proteins, designed to mimic natural olfactory receptors, placed on a gold microelectrode mounted on a two-millimeter-long computer chip.
patientsniffer2 goto SPOT NOSED: A Hi Tech Nose For Disease DetectionOne end of the chip is immersed in a liquid cell containing additional microelectrodes, all of which connect to an instrument that measures electrochemical changes.
At present, the researchers are pumping odor-causing chemicals into the liquid cell to record the signature spectrums that result when the nose receptors encounter them. Skin cancer cells, for example, create distinctive electrochemical patterns, as do bacterial infections, failing organs and other tissue cells, even when they are healthy.
So far, the researchers have worked with an olfactory receptor protein from rats and one from humans. The proposed electronic nose will need several hundred such proteins to detect multiple smells.

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Flashback: Novel Olfactory Sensor Developed

ureabanner Cold but Clean: Urine For Sale
This one is sure for aficionados of “the bionic, the bomb, the puff, the blow, the black, the herb, the sensie, the cronic, the sweet Mary Jane, the shit, Ganja, split, reefa, the bad, the buddha, the home grown, the ill, the maui-maui, the method, pot, lethal turbo, tie, shake, skunk, stress, whacky, weed, glaze, the boot, dimebag, Scooby Doo, bob, bogey, back yard boogie.”
Site
(hat tip: Kevin M.D. )

The FDA just recently cleared the Sequitor Steerable Guidewire, from Biosphere Medical, to be marketed the US. BioSphere Medical Inc. is the innovative medical device company using bioengineered microscopes to treat uterine fibroids, hypervascularized tumors and vascular malformations by a procedure called embolization. Here’s how Sequitor follows up on that:

Designed specifically to address the needs of interventionalists, Sequitor facilitates the placement of catheters within the peripheral vasculature for various interventional procedures, including both uterine fibroid embolization and embolization of hypervascularized tumors, such as liver tumors.
The Sequitor has the following characteristics:
– A durable atraumatic polymer tip that reduces the risk of vascular spasm but retains its shape for selective vessel access;
– A highly visible distal segment, comprised of a radiopaque coil and polymer jacket, which provides visibility under live imaging;
– A specially tempered wire core designed to transmit one-to-one torque response without kinking; and
– PASSTHRU(TM) lubricious, hydrophilic coating that facilitates wire trackability.

BioSphere Medical will start shipping of Sequitor in early July.
Press release
Company website

3452355 New Material Holds Promise for Vascular Grafts
It is not an uncommon procedure to surgically replace a clogged artery with an engineered replacement. Virginia Commonwealth University claims that they have developed a promising new material for this purpose:

The material is a blend of polydioxanone (PDO), a synthetic biodegradable polymer that has been used in suture materials for years, and elastin fibers, used to enhance elasticity and bioactivity of the graft. Elastin, a natural polymer, is also a major component of the arterial wall and is critical to the graft in providing a base for the cells to recognize and interact with the body. Using a technique known as electrospinning, researchers were able to manipulate the PDO-elastin composite into a conduit, or hose, for use as a small diameter vascular graft.
“We have created a vascular graft with a combination of strength and bioactivity – two things we need to maintain and regenerate the graft. Although the body is the best bioreactor for tissue regeneration or wound healing, we hope this new material will be recognized by the body as an environment conducive for regeneration,” said lead author Gary Bowlin, Ph.D., the Harris professor of biomedical engineering in the VCU School of Engineering.
According to Bowlin, the composition of the material reinforces the graft’s mechanical strength, which is critical in order to hold the blood pressure and forces while the regeneration process is taking place. The PDO-elastin blend undergoes slow degradation and causes few adverse reactions compared with previous materials used for the same purpose, he said. The purpose of the new material would be to help a patient regenerate a new artery. If it works as designed the researchers hope that at six months post-surgery, there would be no more synthetic structure left, he said.

The materials currently available for vascular grafts are not ideal, the most popular of which is ePTFE (Teflon…expanded polytetraflouroethylene if you’re really curious), which has been used since 1975 and remains in the body forever once implanted, potentially leading to clots and complications later on. We’re hopeful that this new material will become a succesful replacement.
Read the press release here

Art

genomedance20060614 Dancers Plier about DNAScience is starting to become a hot commodity. There have been recent attempts to make research accessible to the masses. What people will probably find is that these cryptic scientific papers will make them feel like they don’t know how to read, which is not uncommon to how we feel when reading “the literature.” There is definitely a communication problem in the science community, both on the science-to-science and science-to-public ends. This is how Liz Lerman, a clever choreographer, felt. Deciding to address this issue through her own work, she created Ferocious Beauty: Genome, a dance about the human genome.

Wesleyan, a small, private university in Middletown, Connecticut, led in commissioning the genome dance project after Pam Tatge, director of the university’s Center for the Arts, saw Lerman’s troupe perform. Lerman, known for her choreography of political and social issues and her intergenerational troupe of dancers, mentioned her desire to do a dance based on the human genome. So Tatge introduced her to Laura Grabel, a professor of biology who was then dean of natural sciences and mathematics at Wesleyan. Grabel danced professionally herself while she was in graduate school and as a postdoctoral fellow, and she was intrigued by the idea of using dance to communicate science to the public.
As artists-in-residence at Wesleyan, Lerman and Dance Exchange members immersed themselves in the life of a campus already known for its strength in the arts as well as the sciences. They joined a class that Grabel teaches with philosophy professor Lori Gruen, called “Reproduction in the 21st Century,” inventing science in movement, such as a menstrual cycle dance. They also met with Wesleyan’s dance faculty and taught a master class for dance students.
To prepare themselves to create a dance about genetics research, the promises it makes, and the issues it poses, the dancers began getting to know the science faculty in their native habitat. Lerman filmed Grabel studying the development of mouse embryos. Dancer Ted Johnson-who eventually performed the role of pioneering monk- geneticist Gregor Mendel in the two-act, multimedia production-got acquainted with biology professor Laurel Appel’s room full of fruit flies.
…At first, Wesleyan’s science faculty was concerned about whether Lerman and her dancers could get the science right in their genome dance. The professors needn’t have worried. The choreographer and her troupe spent six months immersing themselves in the history and concepts of genetics and the Human Genome Project. “She asked such good questions,” Laurel Appel recalls. “She said, ‘Our toolkit is movement, costumes, lighting, and music. What is your toolkit?’”
In February 2006, Ferocious Beauty: Genome premiered at Wesleyan to a sold-out house and a rave review in the New York Times. The Dance Exchange also presented the performance at Williams College in Williamstown, Massachusetts during February. The journal Science published a photo of the dancer playing Gregor Mendel, garbed in flowing white, guiding another white-clad dancer on a journey that retraces evolution’s footsteps, and the Chronicle of Higher Education reported on the singular production, which explores not only the history of genetics, but its implications for society, particularly in issues of ancestry, aging, and perfection.

We are looking forward to the next generation of doctors who will study radiology from their professors through interpretive dance.
Read the full article here

62456225 Device for Transplantation in Diabetes Shows PromiseHere’s some interesting research into islet cell transplantation for the treatment of type I diabetes mellitus. Using a specialized implant, pre-vascularized to keep islet cells going, scientists out of the Diabetes Research Institute at the University of Miami, Leonard M. Miller School of Medicine (DRI), have shown a potential for its clinical use. From the press release:

In patients with type 1 diabetes, the immune system mistakenly attacks islet cells in the pancreas – the cells that produce insulin to regulate the body’s levels of blood sugar. In islet cell transplantation, insulin-producing cells are harvested from donor pancreata and injected into the liver through that organ’s portal vein – the main blood supply into the liver…
In the study, investigators implanted a 2 centimeter-long device (about one inch) with a diameter of approximately half-a-centimeter into an animal model. The device is made of biocompatible stainless steel mesh and polytetrafluoroethylene (PTFE) plastic caps and a plug (see photo) .
The device was left implanted for 40 days during which tissue and new blood vessels proliferated around and inside it. The plug retains space inside the mesh. After 40 days, through a small incision, the plug is removed and islet cells in a saline solution are injected into the space.
The device is capped and the incision closed.Insulin production was measured within days of islet cell transplantation and proper blood sugar was quickly achieved and maintained. Scientists found no adverse effects even 180 days after transplantation. In laboratory models where the device was removed the diabetic condition quickly returned.
“This alternative to transplanting islets into the liver is easy to perform, easy to evaluate and provides an ideal new site for islet transplantation,” said Pileggi. [Antonello Pileggi, M.D., professor of surgery at DRI ed.] The next step is a larger study to repeat these results and generate more data to present to the Food and Drug Administration.
The eventual objective is to test a similar approach in clinical trials to treat patients with type 1 diabetes, as an alternative to intrahepatic islet transplantation.

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(hat tip: Diabetes Mine)

ClosedStrapfix Study Shows Device Doesnt Improve CPR SurvivalThe latest research, published in JAMA, shows that there is no evidence of improved outcome in device-assisted CPRs. From the press office at Ohio State University Medical Center:

The randomized study, conducted in five North American cities including Columbus, showed that victims of sudden cardiac arrest were more likely to be discharged alive from the hospital if they received manual cardio-pulmonary resuscitation (CPR) rather than CPR administered by the mechanical device…
The study involved 1,071 people who experienced out-of-hospital cardiac arrest in Columbus, Seattle, Pittsburgh, and Vancouver and Calgary, Canada. The study, originally planned to last 12-18 months, was halted in March 2005, nine months after it began, when it became apparent that the study device was not improving long-term outcomes…
In a controlled laboratory setting, the device produced greater blood flow to the heart and brain than manual CPR. But when deployed in real-life emergencies, as provided in the study, researchers found that patients were less likely to survive if they received compressions from the device. In the AutoPulse group, survival to discharge from the hospital was 5.8 percent, while survival to discharge in the manual group was 9.9 percent.

Flashback: AutoPulse Resuscitation System