Archives: 4/2006

454514 Photonic Surgery to Zap Tumors
Put a non-coherent light source together with a semi-coherent article summary and what do you get? A new way of fighting cancer!

A group of Israeli researchers have shown how to carry out surgery using a non-coherent light source. The device could provide a cheaper and safer alternative to conventional laser surgery (Appl. Phys. Lett. 88 114104).
…In 2002, Jeffrey Gordon and colleagues at the Ben-Gurion University of the Negev in Israel developed an alternative to laser surgery that focused ordinary sunlight into a narrow optical fibre using a parabolic mirror. The device can provide the same power and flux levels as lasers but solar surgery is of limited practical value because some countries are sunnier than others.
The team has now achieved similar results using light from commercially available short-arc discharge lamps — a system that does not rely on the presence of sunlight. The set-up uses two mirrors to concentrate the light and a third to “recycle” light emissions…
The device has a number of advantages over lasers — one is that its output contains visible wavelengths, which can penetrate more deeply into tissue than the infrared or ultraviolet radiation from lasers. Another bonus is cost: Gordon says that the system can destroy as much tissue per unit of energy as a laser, but is at least ten times cheaper. The device is also safer than conventional laser systems because the light can be seen, in contrast to lasers that operate outside visible wavelengths.

We’re still getting over the line about how solar surgery’s appeal was limited because “some countries are sunnier than others.” That’s true, yes, but it’s also worth noting most operating rooms are not exactly open to the elements.
Still, we’re glad the research team is no longer reliant on the sun, which has caused far more cancer than it will ever cure. And we’re psyched to see visible-light beams in the OR — they’re safer, penetrate deeper, and have a much bigger ‘wow’ factor than invisible beams.
More from Applied Physics Letters

tru touch Police Use Medgadgets to Diagnose DWI
What do diabetics have to do with drunk driving? Well, the cutting edge technology that enables pain-free glucose monitoring has been applied to measure blood alcohol at the roadside.
Now, we’ve blogged about needle-free blood sugar monitoring before (1,2) but failed to recognize that the market for drunks is at least as big as the diabetes demographic (we suppose it depends on the neighborhood). But the folks at InSight Solutions were sober to this reality, and created TruTouch:

The company’s device generates a beam of infrared (IR) radiation and channels this through optical fibres into a cradle designed to attach to a forearm. When a suspect’s arm is placed in the cradle, the infrared light penetrates to a depth of 5 millimetres and the reflected light is picked up by a bunch of IR sensors. The beam is constantly moved over the skin to avoid burning it.
The reflected beam is combined with the original one to create an interference pattern. This will change depending on the amount infrared absorbed, which will depend on levels of alcohol in the blood…
The device should produce a stable infrared signal for at least two years, the company says. But, to avoid legal challenges, the patent recommends police surgeons periodically check the device for accuracy by putting a piece of gel soaked in pure alcohol into its cradle.

“Police surgeons” ? There’s a scary thought, or maybe a typo. And we’d like to volunteer a few acquaintances of ours to help calibrate the device (in a controlled setting, of course).
More from TruTouch… Including the patent
Via Gizmodo

ENT

354345 Varibel, The Glasses That HearDelft University of Technology from the Netherlands is reporting that its engineers have developed spectacles that can assist patients with hearing difficulties. The product has been picked up by Philips, Frame Holland, the design agencies MMID and Verhoeven, to develop a consumer product:

Many hearing aids intensify sounds from all directions. The result is that people hear noise, but not the people they are speaking to. Because people have such difficulty understanding what others are saying, many people – in spite of their hearing aid – have less social contact with others or must retire from their jobs earlier than desired. The hearing-glasses can provide a solution to this problem, say the experts and users who have tried and tested the Varibel.
The Varibel cannot be compared to traditional hearing aids. In each leg of the glass’ frame there is a row of four tiny, interconnected microphones, which selectively intensify the sounds that come from the front, while dampening the surrounding noise. With this solution, the user can separate the desired sounds from the undesired background noise. Dr. C.H.M. Stengs, ENT specialist at the Rijnstate Hospital in Arnhem, said of the Varibel: “Practical experience with the hearing-glasses supports the theoretical claims that the ability to understand speech is much better. There is a significant improvement in the sound quality.”
With Varibel, natural sounds can still be heard. This solution allows people to hear naturally and clearly in the direction in which they are looking. This has great advantages for daily life. Martin de Jong, audio-technician from Huizen, says: “With the Varibel, the natural sounds that people enjoy are retained. This works surprisingly well. People can hear good and at the same time clearly – and especially in rooms such as in a cafe or at a birthday party.”

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61234232 The Medfusion™ 3500 Syringe Pump
Smiths Medical, a UK based company, has announced that its Medfusion™ 3500 pump has landed the company a hefty contract with Mass General: $3 million and the prestige of being used at the hospital known throughout Massachusetts.
The pump, according to the company, is full of safety features and comes preloaded with a drug library of more than 4,000 meds, over 100 dosing units and “safety dose limits on all infusion parameters to help reduce medication errors that may otherwise occur.”
In addition:

A comprehensive array of pressure-related safety features, including rapid alarm response time and pressure trend displays, is also fully integrated. Add its ergonomic features and flexible communication modes, and the result is clear.
The breakthrough rapid occlusion detection technology with FlowSentry™ offers a comprehensive array of pressure-related safety features. This includes our rapid alarm response time (less than five minutes at 1.0 ml/hr with a 60cc syringe) and reduced false alarms. An enhanced graphic display of pressure trend allows earlier opportunities for clinical intervention and a post-occlusion bolus reduction feature decreases post-occlusion bolus to less than 0.3 ml. All this without the use of expensive dedicated disposable sets.
A horizontal design protects the entire syringe barrel and allows effortless, single-handed loading of all syringe sizes. The large, bright screen with adjustable backlighting complements an intuitive hardware interface.
The Medfusion™ 3500 Syringe Pump imports and exports data as an integrated part of any patient data management system. An improved communication accessory will allow the pump to communicate in any of a number of modes including bar code, ethernet, RS232 and wireless. These protocols may be adapted and customized to interface with your bedside environment.

The question for our readers: identify the medication in the syringe in the picture above (anesthesiologists are prohibited from participation).
More about the pump…

237543 AMA from Down Under: Ban Boxing Before Next GamesThe Australian Medical Association wants to ban boxing from the Commonwealth and Olympic Games, according to a punchy press release:

“A competition in which the winner is determined either by delivering a greater number of blows to his opponent or by literally knocking his opponent senseless is no sport,” Dr Haikerwal says. [Dr Mukesh Haikerwal, the AMA President -ed.]
“Boxing has damaging health effects, both immediate and over the longer term. The potential for serious injury was evident in some of the mis-matched bouts at the Melbourne Games.
“International events based on a spirit of goodwill – such as Olympic and Commonwealth Games – are no place for interpersonal violence and injury.
“As athletes, officials and spectators look forward to the next games, it’s time to remove boxing from the sporting line-up.”
According to the international boxing rules used at Commonwealth and Olympic Games, a boxer scores points by a hit which lands “directly … on any part of the front or sides of the head or body above the belt”.
A knock-out blow also wins a round, and a contestant earns a foul if he avoids being hit by intentionally falling or turning his back – so boxers can be penalised for avoiding serious injury.
Statistics compiled by the USA-based Journal of Combative Sport show that between 2000 and 2005, 53 people died around the world as a direct result of boxing – an average of 10.6 deaths per year.
The AMA opposes all forms of boxing, and has been calling for nine years for boxing to be banned from Commonwealth and Olympic Games, and the World Medical Association has lobbied for a total ban on boxing since 1983.
AMA Queensland President Dr Steve Hambleton also has called for boxing to be removed from the Games bill, saying brain damage and debilitating diseases such as Parkinson’s are recognised consequences of boxing.

(hat tip: Kevin, M.D.)

Art / OTC

damian osullivan proaesthet The proAesthetics Collection
The proAesthetics Collection of porcelain prosthetic devices, was developed by Damian O’Sullivan over a three month period at European Ceramic Work Centre (EKWC) in the Netherlands, according to Core77.

The series reflects the inherent beauty of recovery and mirrors the healing process of our mending bones. Slightly awkward and very fragile, just like us, they cry out, ‘handle with care’!

More at Core77
More at MoCo Loco
damianosullivan.com
(hat tip: WMMNA)

31344 Eyeglasses Through the Ages: An Online ExhibitDavid Fleishman, M.D., an ophthamologist and a curator of an on-line museum and encyclopedia of vision aids, describes the exhibit called “Eyeglasses Through the Ages,” a look at the 730 year history of spectacles:

We generally take for granted one of the world’s most important inventions–spectacles. Imagine what life would be like not being able to see images clearly or sharply. According to a January 11, 1999 feature article in Newsweek Magazine, reading glasses are one of the most important inventions of the past 2000 years. They developed because of the work of artisans, like glassmakers, jewelers and clockmakers, along with some of the most brilliant scientific minds over the centuries. According to Dr. J. William Rosenthal, “Philosophers, monks, mathematicians, physicists, microscopists, astronomers, and chemists all played vital roles in developing this instrument.”

32344 Eyeglasses Through the Ages: An Online Exhibit

No one really knows about the early history of image magnification. In ancient times, someone noticed that convex-shaped glass magnified images. Sometime between the year 1000 and 1250 crude technology began to develop regarding reading stones (simple magnifiers). English Franciscan Friar Roger Bacon (1220 -1292), in his 1268 ‘Opus Majus’, noted that letters could be seen better and larger when viewed through less than half a sphere of glass. Bacon’s experiments confirmed the principle of the convex (converging) lens, described by Alhazen (965-1038) Arabian mathematician, optician and astronomer at Cairo, and even earlier by the Greeks. Bacon recognized that this could assist weak eyes or the vision of aged persons.
Early recorded evidence demonstrates that glasses first appeared in Pisa, Italy about the year 1286. Technically, they were formed from two primitive convex shaped glass/crystal stones. Each was surrounded by a frame and given a handle. These were then connected together through the ends of their handles by a rivet.

Take a stroll through the virtual halls of the exhibition and check out the website itself…
What a nice way to end the week! Thanks for stopping by. Thanks for your readership. We’ll see you Monday!

421432 Nanopore Method for DNA Sequencing
Here’s another example on how nanotechnology might revolutionize medicine. Developed by a team of physicists at the University of California, San Diego, the method to sequence DNA as it passes through nanopore has been shown to be feasible, fast and, probably, cheap:

The paper, published in the April issue of the journal Nano Letters, describes a method to sequence a human genome in a matter of hours at a potentially low cost, by measuring the electrical perturbations generated by a single strand of DNA as it passes through a pore more than a thousand times smaller than the diameter of a human hair. Because sequencing a person’s genome would take several months and millions of dollars with current DNA sequencing technology, the researchers say that the new method has the potential to usher in a revolution in medicine.
“Current DNA sequencing methods are too slow and expensive for it to be realistic to sequence people’s genomes to tailor medical treatments for each individual,” said Massimiliano Di Ventra, an associate professor of physics at UCSD who directed the project. “The practical implementation of our approach could make the dream of personalizing medicine according to a person’s unique genetic makeup a reality.”
The physicists used mathematical calculations and computer modeling of the motions and electrical fluctuations of DNA molecules to determine how to distinguish each of the four different bases (A, G, C, T) that constitute a strand of DNA. They based their calculations on a pore about a nanometer in diameter made from silicon nitride-a material that is easy to work with and commonly used in nanostructures-surrounded by two pairs of tiny gold electrodes. The electrodes would record the electrical current perpendicular to the DNA strand as the DNA passed through the pore. Because each DNA base is structurally and chemically different, each base creates its own distinct electronic signature.

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Developed and described by a team of investigators from the University of California, Davis, and Lawrence Livermore National Laboratory, the test is touted to be more accurate and simple. Unless, of course, you consider the use of a $2 million accelerator mass spectrometer to be a hurdle in the test. And then there are some specially designed bacteria:

The current definitive test for pernicious anemia, called the Schilling test, involves the ingestion of a low but significant amount of radiation and the collection of all urine produced in a 24-hour period. In contrast, the new test uses a single drop of blood and involves negligible radiation exposure – an amount equivalent to that received on a cross-country flight.
To measure vitamin B12 absorption with the new test, the researchers had a healthy male subject drink water containing 1.5 micrograms of purified carbon-14-labeled vitamin B12 (14C- B12), an amount of vitamin B12 equivalent to that found in a 2-ounce steak. Blood samples were taken every hours for the first 12 hours, and then less frequently thereafter to assess absorption of the labeled vitamin. The blood samples were then analyzed at Lawrence Livermore National Laboratory using an accelerator mass spectrometer, a sophisticated instrument that counts single atoms of 14C.
The UC Davis researchers collaborated to create the microscale system in bacteria that produced the 14C- B12 compound and evaluated absorption in a human subject. The team included nutritional biochemists Stephen R. Dueker and Colleen Carkeet at the School of Agricultural and Environmental Sciences, who worked with microbiologists John Roth and Peter Anderson from the College of Biological Sciences to synthesize the new compound in Salmonella enterica, a bacterium that normally produces B12 under anaerobic conditions. It also included Green and Joshua Miller, B and B12 vitamin experts from the School of Medicine, and nuclear physicist Bruce Buchholz at Lawrence Livermore National Laboratory, who designed dosimetry and conducted the accelerator mass spectrometry studies.
“I knew it was technologically possible to create 14C-B12 and use it to measure levels of the vitamin in blood via accelerator mass spectrometry,” said Dueker. “But we were having difficulty finding a strain of bacteria to produce the vitamin with the 14C in just the right place.”
That’s when they turned to fellow microbiology professor John Roth and his postdoctoral fellow Peter Anderson, who was working on a strain of Salmonella bacteria that turned out to be perfect for creating 14C-B12.
“We turned this bacteria into a micromachine for making labeled B12,” said Anderson. “The strain of bacteria was so efficient, that it converted all the labeled material it was given into 14C-B12. Vitamin B12 is one of nature’s most complex substances. By harnessing the power of bacteria, we were able to create the test…”

The research is cool but way, way too far from being clinically implemented.
More in the press release…
More about the accelerator mass spectrometry at Lawrence Livermore N.L…