Archives: 8/2005

angus Ten Tips for SingersThese recommendations are published as a press release from the Center for Voice and Swallowing at The New York Eye and Ear Infirmary. So if you are a singer, check out the press release or this Tips & Exercises for Getting a Great Voice page at the New York Eye and Ear Infirmary.

soundwavesbaha Medgadgeteer On The FrontierSome of our posts on Medgadget are based on the strange emails we receive from our readers — but this post is especially unusual. It concerns a letter we received from Phraust Byte, nickname of a gentleman from Hawaii, who is interested in undergoing a surgical procedure to implant a Bone Anchored Hearing Aid. The BAHA is an electronic device used to correct conductive and sensineural hearing loss.
The thing is, his hearing is not impaired.
Byte’s plan is to use the hearing aid as a permanent set of headphones that can be wirelessly interfaced with any number of other devices. In addition, the BAHA might be used backwards as a microphone picking up the vibrations of the skull while talking.
He wanted us to find an otolaryngologist willing to do the operation.
This represented a bit of a dilemma. We’re wary of the risks of surgery, even when it’s absolutely necessary — and this hardly qualified as necessary. But Byte was persistent.
That’s when it occurred to one of us that Byte could be suffering from sensory dysphoria — like the body dysphoria that leads to cosmetic plastic surgery, or the gender dysphoria documented in sex-change operations. So, after much internal debate, we’ve decided to give this gentleman space to call out for assistance from our readership.
He is interested in learning whether he can undergo this procedure, whether any doctors might be interested in participating in this project, and what regulations govern such a thing. If you have any thoughts on this, email us or Phraust directly at phraust (at) gmail [dot] com
Below is the original letter we received from Phraust Byte:

Hey there,
compactinsitu Medgadgeteer On The FrontierI’ve been looking to get myself a Bone Anchored hearing Aid for about a year now, and I have had the hardest time finding a doctor willing to implant it.
The problem is, I don’t have a hearing problem. In fact, my hearing is better than most. I have no problem however, with installing the titanium screw needed to resonate sound directly into my head. As I see it, it would offer me an “always on” bone mic & speaker, which could wirelessly connect to any of my devices (cell phones, pdas, computer, etc). The technology is easliy within reach for me to build a small wearable wireless unit, much like the sound processor they use with the B.A.H.A. system, but I do not want to lie about my condition (or lack thereof) to the doctor who will be installing this screw into my mastoid.
I’m hoping you can help me find a doctor (I’d really hate to end up in some “hospital” in Tiajuana with a rusty screwdriver and a bottle of tequila…) who is knowledgible in this field (and hopefully who is willing to do the operation for me), or with information regarding the potential hazards of having this done. I do not see why an operation like this shouldn’t be considered optional.
Any help at all will be greatly appreciated, although my luck so far (boingboing, gizmodo, and endgadget) has had no response whatsoever…
With fingers crossed!

That’s right — Medgadget boldly goes where other tech blogs fear to tread. Now we just need an ENT surgeon to put his or her license on the line…
For his more thorough thoughts about this project, take a look at this post.
More at Entific
Flashback: SOL.SuXXOR Cold Virus Detected

nr 6361a Structure of Bacterial Microcompartments DescribedResearchers from the lab of Dr. Todd O. Yeates, a UCLA professor of chemistry and biochemistry, have published a report in the journal Science desribing the 3D structures of newly discovered bacterial microcompartments. The research might open a new frontier in antibiotic development:

Cells of prokaryotes have been viewed as very primitive, although some contain unusual enclosures known as microcompartments, which appear to serve as primitive organelles inside bacterial cells, carrying out special reactions in their interior.
“Students who take a biology class learn in the first three days that cells of prokaryotes are uniform and without organization, while cells of eukaryotes have a complex organization,” Yeates said. “That contrast is becoming less stark; we are learning there is more of a continuum than a sharp divide. These microcompartments, which resemble viruses because they are built from thousands of protein subunits assembled into a shell-like architecture, are an important component of bacteria. I expect there will be a much greater focus on them now.”
Yeates’ Science paper reveals the first structures of the proteins that make up these shells, and the first high-resolution insights into how they function.
“Those microcompartments have remained shrouded in mystery, largely because of an absence of a detailed understanding of their architecture, of what the structures look like,” said Yeates, who also is a member of the California NanoSystems Institute and UCLA’s Molecular Biology Institute. “The complete three-dimensional structure is still unknown, but in this paper we have provided the first three-dimensional structure of the building blocks of the carboxysome, a protein shell which is the best-studied microcompartment…”
The structure of the carboxysome shows a repeating pattern of six protein molecules packed closely together.
“We didn’t know six would be the magic number,” Yeates said. “What surprises me is how nearly these six protein molecules fill the space between them. If you take six pennies and place them in the shape of a ring, that leaves a large space in the middle. Yet the shape of this protein molecule is such that when six proteins come together, they nearly fill the space; what struck me is how tightly packed they are. That tells us the shell plays an important role in controlling what comes in and goes out. When we saw how the many hexagons come together, we saw that they filled the space tightly as well.”

The press release
More at Science…

411245456 Erotic Images, Gore Cause Temporary BlindnessThat’s right. You might experience a temporary state of shock after seeing gore, pr0n or… (maybe) a beautiful woman. From the press release from Vanderbilt University:

New research indicates that people shown erotic or gory images frequently fail to process what they see immediately afterwards.
Portions of the research exploring this effect by Vanderbilt University psychologist David Zald and Yale University researchers Steven Most, Marvin Chun and David Widders will be published in the August issue of Psychonomic Bulletin and Review
Zald and his colleagues set out to determine if the rubbernecking effect carries over into more minute lapses of attention through two separate experiments.
In the first experiment, research subjects were shown hundreds of pictures that included a mix of disturbing images along with landscape or architectural photos. They were told to search the images for a particular target image. An irrelevant, emotionally negative or neutral picture preceded the target by two to eight items. The closer the negative pictures were to the target image, the more frequently the subject failed to spot the target. In a subsequent study, which has not yet been published, the researchers substituted erotic for negative images and found the same basic effect.
“We think that there is essentially a bottleneck for information processing and if a certain type of stimulus captures attention, it can basically jam up that bottleneck so subsequent information can’t get through,” Zald said. “It appears to happen involuntarily…”
In the second experiment, the researchers sought to determine if individuals can override their emotion-induced blindness by focusing more deliberately on the target for which they are searching. In this experiment, the subjects undertook two different trials. In one they were told specifically to look for a rotated photo of a building; in the other they were told to look for a rotated photo of either a building or a landscape.
The research team hypothesized that the more specific instruction-to look for the building only-would help the research subjects override their emotion-induced blindness. After running the tests, the researchers discovered that they were partially right: specific instructions helped some subjects control their attention, but it didn’t help others.

You, animal, you!
The press release

sleepydoc From William Osler to Libby ZionThe topic of residents’ work hours restrictions is still very much discussed in U.S. hospitals, and conversation often comes back to the case of Libby Zion. So, this post is not strictly about medgadgets, unless you consider interns and residents to be medical devices (which, we’re told, some people do).
A well-written overview of the situation can be found online, from the pages of Johns Hopkins Magazine in 2001. Since that article went to press, a residency accreditation often depends on compliance with standards similar to New York’s Bell Commission laws. One wonders what Osler would think:

The residency system in the United States began at Hopkins in 1889 under William Osler, first director of the Department of Medicine and first physician-in-chief of Johns Hopkins Hospital. Following the German model of postgraduate medical training, Osler established a plan in which young physicians trained under an experienced mentor. Residents learned by doing clinical work, taking on increasing responsibilities as they gained more experience, and graduated from intern to junior resident to senior resident to chief. Over the years, other hospitals adopted the Hopkins model, and it became the norm for training doctors.
Osler, who once wrote an essay on the medical profession titled “The Master-word is Work,” expected residents to be fully committed to the role of doctoring. Residents lived at the hospital and were not allowed to marry–rules that continued until the end of World War II. Most residents were so caught up in the intellectually charged atmosphere of the time that they put up with the sacrifices.
“It was an even more grueling job, even more absorbing in the past than now,” says 80-year-old Victor McKusick, University Professor of Medical Genetics. After an internship and junior residency at Johns Hopkins Hospital in the late 1940s, McKusick in 1951 became chief resident on the Osler Medical Service.
“There was very little scheduled off-time,” says McKusick. Interns were on call every other night. Residents worked all through the week and all day Saturday. On Sunday morning, they performed rounds, and then, if they could arrange to leave their patients in the care of a fellow intern or resident, took the rest of the day off.
“We didn’t feel put upon or enslaved,” adds McKusick. “This was just the way it was.”

Those sentiments are echoed in physician memoirs from that period — we fondly recall the writing style of Lewis Thomas.
But some things have changed in hospitals since Osler’s time. Patients are sicker, yet are admitted and discharged much faster. Hospitals and health care are more complex, requiring residents to do more paperwork to get patients connected with appropriate services.

[A] law governing the work hours and supervision of residents arose as a result of outrage caused by the 1984 death of 18-year-old Libby Zion. The teenager was admitted to New York Hospital at midnight with fever and minor flu symptoms. She died seven hours later.
SidneyZion From William Osler to Libby Zion
The immediate cause of Libby Zion’s death is still debated. One factor may have been the potentially lethal combination of the drugs Nardil, which Zion had been taking, and Demerol, which she was given in the hospital. But her father, Sidney Zion [pictured right], a journalist and former federal prosecutor, blamed severe flaws in the residency training system as the underlying cause. He launched a passionate campaign, arguing that lack of sleep on the part of the intern and resident, and inadequate supervision by the attending physician, contributed to this medical blunder.
A grand jury in New York heard the case but did not indict the doctors involved. Instead, it implicated the residency system as a whole.
The case prompted the New York state health commissioner, David Axelrod, to form a committee to investigate issues in emergency care, including the training of physicians. It was headed by Bertrand Bell, a Distinguished University Professor and professor of medicine at Albert Einstein College of Medicine. After 19 months of testimony, the Bell Commission issued a report recommending specific limits on residents’ work hours and stricter rules regarding their supervision.
In 1989, New York enacted changes in its health code that roughly followed the Bell Commission’s recommendations. According to Code 405, residents may work no more than an average of 80 hours per week. They must have off at least one 24-hour period per week and at least eight hours between shifts. The law also requires that an experienced supervising physician be in the hospital at all times or, in certain cases, no more than 30 minutes away from the hospital.

These changes were not entirely popular among established physicians — published comparisons were made to clock-punchers and those who chose sleep over care.
Bell responds:

“Here’s what the story really is,” says Bell. “Graduate residents are in an educational program. The person who gets paid to take care of the patients in the hospital is the attending doctor; he’s responsible.” He also adds that the Bell Commission focused more on supervision of residents than on work hours, although the latter issue has attracted far more attention.
“Not only can’t you expect people who are chronically sleep-deprived to do well, you can’t expect people like that to learn and be empathetic,” he says, noting some studies that suggest residents have higher rates of depression, drug abuse, divorce, and early labor. “You want to have people who are lovely and pleasant and want to help the world, and at the same time have the support to do it,” he says.

house of representatives From William Osler to Libby Zion
Administrators and the public largely agree, and starting in 2003, an 80-hour work week was required for most programs to maintain accreditation, with federal legislation to follow. A collection of data on the adverse affects of long work hours is at AMSA’s site — including medical errors on hospital floors, and even physician car accidents post-call.
So, it remains to be seen whether the bond between physicians and patients has been fundamentally altered by adopting clock-punching rules. But we can take heart that improved safety means more patients (and doctors) will survive the hospital encounter.
That does it for this week. Have a great weekend and we’ll see you on Monday!

img MED GuardRT prod Guardian® RT Continuous Glucose Monitoring SystemMedtronic is announcing that the FDA has approved its real-time Guardian® RT Continuous Glucose Monitoring System. Medtronic believes that its monitor will provide better diabetic monitoring and management.
This is how the system works:

The Guardian RT system is not implanted. A tiny sensor inserts easily under your skin in a virtually painless process. Once the sensor is in, the system records glucose levels every five minutes and sends them automatically to a discrete monitor that you wear like a pager. The sensor measures glucose in the interstitial fluid found between your body’s cells. You typically discard and replace the sensor after three days of use. Alarms can be set to alert you to potentially dangerous highs and lows. Trend reports and charts can be viewed once data is downloaded to a personal computer using Solutions™ Software for Guardian. You are still required to take fingersticks prior to adjusting therapy and in order to calibrate the glucose sensor…
The Guardian RT system is indicated for use by Type 1 and Type 2 diabetes patients, 18 years and older, who desire better glucose control to improve their health and quality of life.

More at Medtronic

nanotube nsf sm A Smart Bio NanotubeThe National Science Foundation (NSF) is reporting that scientists from the University of California, Santa Barbara have created some novel bio-nanotubes. These molecular structures one day could potentially function as “smart” drug delivery systems: on demand and in precise location.

The nanotubes are “smart” because they can open or close at the ends, depending on how the researchers manipulate the electric charge on the two components. So in principle, a nanotube could encapsulate a drug or a gene, and then open on command to deliver the cargo where it would have the best effect.
The tube’s components play roles similar to skin and bone. The “skin” is a soap-bubble-like arrangement of molecules known as a lipid bilayer, akin to the bilayer that forms the cell’s protective outer membrane. The “bone” is a hollow, cylindrical structure known as a microtubule, which is ubiquitous in the cell’s internal cytoskeleton, the system of nanoscale struts and girders it uses for internal transport, structural stability and many other purposes. The researchers have found that when they combine the two components and control the conditions properly, open or closed bio-nanotubes will assemble themselves spontaneously.

The NSF press release
The UCSB press release
The abstract

ELAD ELAD Enters the Wound Dressing FrayThe people at Isracast have alerted us to this story about a potential replacement for both the tourniquet and compressive bandage, called the ELAD (for elastic-adhesive):

The ELAD successfully eliminates the disadvantages of the techniques and equipment currently in use by providing a self-adhering elasticized compression dressing. The self-adhering surface provides superior compression and affords simple rapid use of the rolled dressing over diversely shaped body parts. The bandage requires minimal extension in the application, and is therefore particularly suited for use in confined spaces and where no assistance is available. Effective control of bleeding is achieved by variable compression over the absorbent pad. This pad can incorporate a coagulant for further efficacy when used on surface areas where high compression pressures are difficult to achieve (neck, groin). The bandage is constructed of transparent material, so that it will be possible to visually observe possible continued bleeding. The main advantage of the ELAD is it ability to stop bleeding quickly, thus freeing the paramedic or doctor for other lifesaving activities.

We thought this kind of sounded like Saran Wrap, and indeed, the inventor, Dr. Sody Naimer, admits the material is quite similar. He also has some critical words for another Israeli wound dressing recently blogged about here.
More from Dr. Naimer’s published abstract…

brilliant Patient Bracelet Confirms Medications, DosesRegular Medgadget tipster Vlad sends along this BBC report about a new patient bracelet that checks for medication errors:

The “Brilliant” wristband contains a sensor to scan medicines, and a chip.
The chip is programmed on the patient’s arrival at the hospital with their details and drug requirements.
When a drug bottle or pack is placed on the wristband’s sensor, this scanner checks the electronic tags built in to the medicine’s packaging to make sure it is correct for the patient.
The wristband then informs the nurse if the correct drug has been selected by displaying this information on the wristband’s screen.
Each time a dose is given, the date and time are logged in the chip contained inside the wristband. This information can be downloaded to a hospital computer.

This bracelet, designed by student Claire Dunne, lives up to its name. It’s a good deal more useful than the ID bracelets patients wear today, which haven’t changed in decades.
More from Dunne’s entry in the Brunel design competition…