Archives: 8/2005

OTC

144221 Samsungs Super Washing Machine on a Mission to Kill BacteriaSamsung introduced a new line of washing machines with SILVER WASH, an advanced washing technology with superb bacteria killing capabilities.
Samsung says:

Imagine 400 billion silver ions dissolved in water to make a super cleaning solution that affects your clothes at an almost molecular level.
Its sterilizing ability of 99.99% and lasting antibacterial action will redefine your idea of purity.
SILVER WASH utilizes 99.99% pure silver for a lasting investment for your health and garments.

These super washing machines will for now only be sold in Australia and New Zealand.
Read more at Samsung New Zealand

ekg Electrocardiogram for Sleep Analysis
Our experiences with sleep-lab technology have been both impressive and disappointing — at much time and expense, patients are hooked into elaborate contraptions, to be monitored all night by staff and cameras and equipment. Yet the reams of generated data sometimes yield few clues as to what’s really wrong with the patient. That might begin to change, with the addition of a simple EKG, according to docs at Beth Israel Deaconness:

The new study, led by sleep researcher Robert Thomas, MD, of BIDMC’s Division of Pulmonary, Critical Care and Sleep Medicine, identified two distinct types of behavior exhibited throughout the course of a person’s sleep, the first being stable and restful, the second being unstable and aroused. The results show that conventional approaches to categorize non-REM (non-rapid-eye-movement) sleep into grades of depth do not capture this potentially important dimension.
“Among healthy adults, physiological behaviors will show relatively abrupt shifts– occurring over minutes–between both stable and unstable sleep, but the stable stage clearly dominates,” explains Goldberger, who is also a Professor of Medicine at Harvard Medical School. “But,” he adds, “in a variety of disease states, the spectrogram shows that an unstable sleep pattern is predominant, and among patients with severe cases of sleep apnea, virtually all of the patient’s non-REM sleep is unstable.”

More from the exciting journal Sleep

ENT

PULSAR MED EL Corporations new Cochlear Implant SystemCochlear implants were developed in the 1970′s to help individuals with severe to profound hearing loss who gain little or no benefit from hearing aids. Patients wear a small speech processor behind the ear that picks up sound from the environment and transmits it to an internal component using specialized radio-frequency transmission.
MED-EL Corporation, an implantable hearing technology firm, introduced the PULSARCI100, which offers some of the most highly advanced cochlear implant technology available in the United States. This new implant is the first to incorporate I100 technology, a highly durable and power-efficient electronics platform with wafer-thin layers of sophisticated electronics arranged on a single miniaturized chip.
The PULSARCI100 has also been proven safe and compatible for use with magnetic resonance imaging (MRI) at a field strength of 0.2-Tesla. Other cochlear implant devices require a surgical procedure to remove the implant’s internal magnet before an MRI scan can be performed. MRI with MED-EL Cochlear Implants does not require any additional surgery.

“We have been waiting for the opportunity to offer this device to our patients because of the new, advanced electronic design and the chance to provide patients with the absolute latest in cochlear implant technology,” says Dr. Pillsbury of the University of North Carolina at Chapel Hill.

Read more about this new implant at MED-EL Corporation’s web site

hopkins1 Nausea Neutralizer
According to New Scientist, researchers at Johns Hopkins have a patent to treat nausea with an implantable metal rod. The implant would stimulate the vagus nerve in a pulsatile manner, adjustable to individual patients, and controlled by remote. The report (second item down) says:

A small metal rod, wrapped in a metallic coil, is inserted beneath the skin on a patient’s neck, close to the vagus nerve. When a similar coil is then held outside the neck and pulsed with low voltage current, the inserted rod should stimulate the vagus nerve and disrupt the sense of nausea felt by a patient.
JHU says that the strength and frequency of pulses must be set by a physician to suit the individual patient. But then a patient needs only to hold a battery-powered device to their neck and press a button when they feel uncontrollably sick.

One hopes that tinkering with this cranial nerve doesn’t affect its other functions, like slowing the heart. The Hopkins scientists assure us not to worry, but then again, they misspelled the title of their patent (“Method for Trating Nausea” ?)
More from the JHU patent(.PDF)…
Flashback: The body’s other brain

As a result of server problems last week, and outages this week related to Katrina, we’ve lost a fair number of reader emails.
If you wanted to join our mailing list, or had a tip or comment to share, please re-send your emails. And thank you for your support.

twinject New Twinject Epinephrine PenThe San Diego based Verus Pharmaceuticals Inc. is a “one trick pony,” selling only its new Twinject epinephrine pen, which gives 2 doses of epinephrine.
Currently, the Twinject is the only competitor to the EpiPen, made by Napa-based Dey LP. As you could guess from the name, the Twinject contains a second dose of epinephrine, which is a full 100% better (!!!) than the EpiPen’s single dose. According to the San Diego Business Journal article, 36% of users need a second dose within 5-10 minutes of the first.
The jury is still out as to whether or not this will spawn a disposable razor-like waterfall of 3 and even 4 dose epinephrine injectors.
Twinject product site

superdome Katrina Relief
Our thoughts and prayers are with the people suffering from the aftermath of Hurricane Katrina. If you want to help, a place to start is the Network for Good, a site listing the many charity and relief organizations involved.

ivmri IntraVascular MRI (IVMRI) Catheter
In an article at the Globes [online], we read about TopSpin Medical from Israel, the developer of intra-vascular MRI (magnetic resonance imaging) catheter for coronary arteries.
This is how the company describes its interesting new technology:

TopSpin Medical has developed a self contained “inside-out” miniature MRI probe in a tip of an intravascular catheter that allows for local high-resolution imaging of blood vessels without the need for external magnets or coils. The advantages of this technique range from the very practical aspect of a low-cost system (since no expensive external setup is required), accessibility to the patient during the procedure, compatibility with existing interventional tools, and finally resolution and diffusion contrast capabilities that are unattainable by conventional clinical MRI, due to the strong local gradients created by the probe and its proximity to the examined tissue.
The intravascular probe serves as a first example for a wide range of applications for this method, which in the near future may the field of clinical MRI. It opens the door for the application of MRI in cases where high-resolution local images are required and when the transformation into an MRI environment is both mentally and economically difficult for the hospital. The medical applications for this technology include detection and staging of prostate cancer, imaging tumors in the colon, lung and breast and intravascular imaging of the peripheral vasculature…
A static magnetic field of about 0.2 Tesla is generated by strong permanent magnets located at the tip of the catheter. The gradients that result from such a small configuration are in the range of 100-300 T/m, and may be controlled to some extent by changing the angle of the magnetization and the dimensions of the gap between the two magnet pieces. Due to volume constraints, a single coil is used both for transmission and for reception. The magnetic field profile created by this “inside-out” probe within the imaged volume is significantly different from that created by conventional NMR or MRI setups.

To read more about the IVMRI catheter, go to this page.
The company’s website

anthraxprot Detecting Anthrax Proteins at Ultralow ConcentrationsA new diagnostic method to detect ultralow concentrations of active anthrax proteins in an infected blood sample has been described by researchers from the National Institute of Standards and Technology (NIST), the U.S. Army Medical Research Institute of Infectious Diseases and the National Cancer Institute:

Current detection methods rely on injecting live animals or cell cultures with samples for analysis and require up to several days before results are available. Described in an upcoming issue of the Journal of Biological Chemistry, the new method produces unambiguous results in about an hour. The researchers hope the system will ultimately be useful in developing fast, reliable ways to diagnose anthrax infections or to quickly screen large numbers of drugs as possible therapies for blocking the bacteria’s toxic effects.
The method works by detecting changes in current flow when anthrax proteins are present in a solution. An anthrax protein ironically called “protective antigen” spontaneously forms nanometer-scale pores that penetrate the surface of an organic membrane. When a voltage is applied across the membrane, positively and negatively charged ions flow freely in both directions through the pore. When additional anthrax proteins called lethal factor (LF) or edema factor (EF) are present, however, the proteins bind to the outside of the pore and shut down the flow of ions in one direction. This change in current flow depends on the concentration of the proteins in the solution and can detect amounts as low as 10 picomolar (trillionths of a mole).
“We hope this system will lead to a method for rapidly screening agents that inhibit the binding of LF or EF to these pores,” says NIST’s lead investigator John Kasianowicz.

The press release