Archives: 4/2005

nmr berkeley Portable High Resolution NMR Sensor Demonstrated at BerkeleyInteresting research with implications for public safety is coming out of Berkeley:

Homeland security experts may soon be getting a valuable new tool for identifying the chemical constituents in suspicious substances. A portable device makes it possible for the first time ever to take high-resolution NMR spectroscopy – one of the principal tools for chemical analysis – out of the laboratory and into the field for use on samples of any size.
“Our device does not compete with the superconducting magnets that are used to study proteins, but there are many applications, besides homeland security, where you can’t bring samples from the field to the laboratory, including medical diagnosis, archaeological analysis, or the exploration of objects in space, like planets or moons,” said chemical engineering graduate student Vasiliki Demas, one of the co-authors of a paper describing the portable NMR device, which appears in the April 8, 2005 issue of the journal Science.
NMR is a phenomenon involving the atomic nuclei of molecules in which at least one proton or neutron is unpaired. The imbalance causes such nuclei to spin on an axis like miniature tops and gives rise to a magnetic moment, which means the nuclei act as if they were bar magnets with a north and south pole. When a sample is exposed to a strong external magnetic field, these spinning “bar magnets” attempt to align their axes along the lines of magnetic force. The alignment is not exact, resulting in a wobbly rotation about the force lines that is unique for each type of nuclei. If, while exposed to the magnetic field, the nuclei in a sample are also hit with a radiofrequency (rf) pulse, they will absorb and re-emit energy at specific frequencies according to their individual rates of rotation. These frequencies show up in an NMR spectrum as distinct peaks of varying height that, like a set of fingerprints, can be used to identify the sample’s constituent nuclei.
Because the rate at which resonating nuclei realign themselves with magnetic field lines is heavily influenced by their neighboring nuclei, NMR can also be used to provide detailed information on the structural, dynamic, and spatial relationships of atoms in a sample. Deviations from reference peaks on the NMR spectrum, called “chemical shifts,” reflect different concentrations of a sample’s constituent nuclei and can be used to positively identify the molecular composition and chemical nature of the sample.
Until recently, high resolution NMR spectroscopy could only be done by placing a sample inside the bore of a very large stationary magnet that produces a strong, uniform magnetic field. Portable NMR systems with open, single-sided probes, have been built, but the lack of uniformity in their magnetic fields limit them to low resolution.
“The variations within the magnetic fields of previous portable NMR devices are usually orders of magnitude too large to detect chemical shifts,” said Demas. “These devices mainly yield relaxation times as a crude estimate of a sample’s composition.”
Said Meriles at the time this technique was announced, “We have demonstrated that high-resolution NMR spectra can be recovered even with a strongly inhomogeneous magnetic field, which means it may be possible to develop a mobile magnet that can be scanned over otherwise inaccessible objects to get magnetic resonance information.”

In the picture above, you can see Vasiliki Demas, one of the co-authors, loading a sample for analysis inside a low-field electromagnet, currently being used as a testbed for obtaining high-resolution NMR spectra without the constraints of having to place samples inside the bore of a high-field magnet.
More at Berkeley Lab

primodoll Primo Puel Doll: Making Golden Years Golden in JapanFrom the BBC:

Seventy-eight-year-old widow, Akino Okano, is lonely.
To help combat the loneliness of longevity – and in true Japanese style – the country has turned to technology for guidance.
Akino has been introduced to Primo Puel, an interactive doll that talks, giggles and even asks for cuddles.
It provides her with much of the company she longs for, especially in the evening.
Originally designed to be a substitute boyfriend for young single girls in the workforce, the doll has become an unexpected hit with elderly people across Japan.
Since they came on to the market five years ago, more than one million dolls have been sold.
Based on the well-known properties of animal therapy, Paro has been designed to provide relaxation, entertainment and companionship through physical interaction.
Covered in soft white antibacterial fur, Paro’s artificial intelligence means it can mimic animal behaviour and over time, even develop its own character.
Sensors beneath its fur and whiskers trigger the seal to move and respond to petting. It’s eyes open and close, and its flippers can move too.
Other in-built sensors mean Paro can respond to sight, sound, temperature and even posture. Although not able to talk, the latest Paro models can recognise seven different languages.

Others have Japanese Schoolgirl Watch. Is it time for us to start Japanese Babushka Watch?
More at the BBC

lectures78x105 Reith Lectures 2005 (part 2)The second Reith lecture in the series The Triumph of Technology presented by the BBC, is scheduled for broadcast today at 8.00pm GMT. The lecture is titled Collaboration and will be presented at the University of Cambridge by Lord Alec Broers, President of the Royal Academy of Engineering and Chairman of the House of Lords Science and Technology Committee. To hear it live go here. Once the lecture audio and transcripts become available, we will provide the link.
More here
UPDATE: The .mp3 and .ram of the second lecture are located here.

Paint us surprised.
The American Society of Plastic Surgeons (ASPS) and the American Society for Aesthetic Plastic Surgery (ASAPS) disappointed, not surprised.

smartpill Fastastic Voyage: Smart Pill to Expand Testing
The SmartPill gastrointestinal mapping system is expanding to a third medical center, according to Business First of Buffalo. From the company’s website:

The patient swallows the SmartPill Capsule which contains two subminiature radio transmitters. The SmartPill Capsule’s transmissions are received by a small, patient worn Mobile Receiver/Controller. Site-specific data is captured in real-time as the capsule passes through the GI tract. The SmartPill Capsule is not absorbed nor does it interact with the GI tract in any way other than its propulsion via peristalsis, eventually exiting through the colon (usually within 24 hrs).
The second generation SmartPill GI Monitoring System, featuring Ambulant Capsule Technology II (ACT II) in development, will enable real-time, site-specific tracking of the SmartPill Capsule’s position within the GI tract. ACT II tracking software will discriminate multiple capsules and track them simultaneously in a patient, as they transit the bowel, by repeatedly mapping or monitoring the entire GI tract. In addition, the SmartPill ACT II System will provide Gastroenterologist and researchers with a real-time diagram of the patient’s alimentary tract.

Though the SmartPill can measure pH, temperature, and pressure, it doesn’t take pictures. Future versions, however, plan to incorporate drug delivery.
They say it’s just a little larger than a multivitamin. But at $425 a pop, it’s not immediately apparent whether the devices are re-usable.
More at Smart Pill Diagnostics

medtronic Medtronic Restore for Chronic Neurogenic Pain
Via BusinessWeek, a report that Medtronic has received FDA approval for its Restore device:

The Restore is a stopwatch-sized device that sends electrical pulses to the spine via eight electrodes to block pain signals from reaching the brain. The device is approved to treat chronic pain, or pain that recurs for more than six months, associated with such spine-related conditions as failed back syndrome, post laminectomy pain, unsuccessful disc surgery or degenerative disc disease.
…The company said the device is an improvement over similar pain-relief devices in that the battery only needs to be charged once a month rather than once a week. Medtronic said the battery in the Restore can last for up to nine years.

More at Medtronic, Inc….

ekg wirel 1 The EKG, Untangled
Another recent MDEA winner (I get the feeling they hand out a lot of these awards) is the LifeSync Wireless electrocardiogram:

Through its unique and patented design, the LifeSync® System eliminates lead wires and trunk cables between patients and bedside, 12-lead or transport ECG monitors, allowing freedom of movement throughout the hospital. Using highly-sophisticated Bluetooth® wireless technology, the LifeSync® System employs two-way radios to collect and transmit patient ECG and respiration data to the hospitals existing ECG monitors. The LifeSync® System can be implemented easily without costly changes to a hospital’s infrastructure.
lifesync The EKG, UntangledThe LifeSync® System is designed to save critical nurse time by eliminating the need to detach and reattach lead wires when transporting patients, and also facilitates patient mobility and ambulation. The system provides the opportunity for enhanced patient comfort and may reduce the risk of cross contamination from the reuse of improperly cleaned lead wires. The LifeSync® System is indicated for continuous monitoring, diagnostic 12-lead ECG and stress testing.

One small box, the “patient transceiver,” is strapped to the arm, with collated, disposable leads around the precordium. The patient transceiver sends data via bluetooth to the “monitor transceiver”, which can plug into any old 12-lead EKG machine or telemetry system.
Pretty cool! This could go a long way toward eliminating tangled leads, and the false alarms, messy reads, and inevitable delays that come with them.
More from GMP Wireless Medicine

insorb Insorb Resorbable Subcuticular Skin StaplerAnother MDEA award winner (they’re everywhere!) in the field of wound closure comes from Incisive Surgical, Inc:

The revolutionary INSORB® Subcuticular Skin Stapler is designed to combine the cosmetic result of absorbable sutures with the rapid closure times associated with metal skin staplers, while eliminating the need for metal staple removal post-operatively.
The patented INSORB 20 Subcuticular Skin Stapler is a sterile, single patient use device that deploys up to 20 staples, sufficient to close an 17cm incision.

Between this, the ClozeX, and other devices in use or in the pipeline, it would seem that, for superficial skin lacerations, the era of traditional needle suturing might draw to a close. And why not? Working with needles is slow and dangerous, and frankly, gadgets are more fun.
More at Incisive Surgical including some impressive patient photos

luke skywalker DARPA Encourages a Prosthetic Revolution
My brief experiences with DARPA led me to believe they were a very forward-thinking group, with the sharp minds and big pockets necessary to back ideas that may not pay dividends for decades.
So it was with some surprise that I read (via Gizmodo and Defense Tech) that DARPA is challenging scientists to create a fully functional prosthetic arm in four years.

It is understood that research in many areas will be required in order to reach the ultimate goal. These research areas may include, but are not limited to: neural control, sensory input, advanced mechanics and actuators, and prosthesis design and integration. Achievement of program milestones/metrics will demand prompt identification of areas requiring further research and rapid incorporation of advancements made in these areas into the prosthetic device. Because of the need to quickly and safely incorporate new technologies into the final product for IND submission, successful proposals will contain an assessment/analysis of the current “state of the art” in the field of upper extremity prosthetics along with a clear statement of the integrated vision for this effort. Offerors must detail the critical components of a “revolutionary prosthesis” and address how their collective team will achieve those challenges.
DARPA considers the ability to provide neural control to the prosthesis to be essential to achieving the desired outcome of restoring full motor and sensory capabilities. There has been recent success supported by DARPA and others in collecting signals from the motor cortex and/or other regions of the brain and using them to control robotic devices. It may also be possible to develop interfaces with the peripheral nervous system that provide an efferent and afferent signaling connection with the prosthesis, though this is less well demonstrated. Proposers must support their selected control system(s) in terms of existing capabilities and promise; however, proposals that do not utilize neural control as a significant mechanism for controlling the prosthetic are not of interest.

I commend them for their ambition. Advanced prosthetics are needed now more than ever, due to advances in battlefield resuscitation and changes in the way war is waged. And with recent lab breakthroughs in neural processing and device manipulation, DARPA’s challenge might move the focus to clinical trials and bedside application. Whether it’s the right stimulus at the right time, or irresponsible optimism, I’ll bet there are a lot of hopeful veterans today.
More at DARPA’s Defense Science Office