Archives: 4/2005

centrif nasa Short Radius Centrifuge at NASA
NASA has a new tool to study the physiologic effects of microgravity:

For the first time, researchers will systematically study how artificial gravity may serve as a countermeasure to prolonged simulated weightlessness.
“The Vision for Space Exploration includes destinations beyond the moon,” said Dr. Jeffrey Davis, director of JSC’s Space Life Sciences Directorate. “This artificial gravity research is an important step in determining if spacecraft design options should include artificial gravity. The collaboration between NASA, the National Institutes of Health (NIH), UTMB and Wyle Laboratories demonstrates the synergy of government, academic and industry partnerships,” he added.
For the initial study this summer, 32 test subjects will be placed in a six-degree, head-down, bed-rest position for 21 days to simulate the effects of microgravity on the body. Half that group will spin once a day on the centrifuge to determine how much protection it provides from the bed-rest deconditioning. The “treatment” subjects will be positioned supine in the centrifuge and spun up to a force equal to 2.5 times Earth’s gravity at their feet for an hour and then go back to bed.
“The studies may help us to develop appropriate prescriptions for using a centrifuge to protect crews and to understand the side effects of artificial gravity on people,” said Dr. Bill Paloski, NASA principal scientist in JSC’s Human Adaptation and Countermeasures Office and principal investigator for the project. “In the past, we have only been able to examine bits and pieces. We’ve looked at how artificial gravity might be used as a countermeasure for, say, cardiovascular changes or balance disorders. This will allow us to look at the effect of artificial gravity as a countermeasure for the entire body,” he added.
The research will take place in UTMB’s NIH-sponsored General Clinical Research Center. The study supports NASA’s Artificial Gravity Biomedical Research Project.
“Physicians and scientists from all over the world will travel to UTMB to study the stresses that spaceflight imposes on cardiovascular function, bone density, neurological activity and other physiological systems,” said Dr. Adrian Perachio, executive director of strategic research collaborations at UTMB. “This is an excellent example of collaboration among the academic, federal and private sectors in research that will benefit the health of both astronauts and those of us on Earth,” he added.
The centrifuge was built to NASA specifications by Wyle Laboratories in El Segundo, Calif. It was delivered to UTMB in August 2004 and will complete design verification testing, validation of operational procedures and verification of science data this spring. The centrifuge has two arms with a radius of 10 feet (3 meters) each. The centrifuge can accommodate one subject on each arm.

The press release
Short-Radius Centrifuge at NASA…

unique condom Pasante UniqueThe breakthrough:

This revolutionary new non-latex condom is unlike any other condom available, providing much greater sensitivity without compromising on safety.
Made from “AT-10 resin”, this condom is up to 70% thinner than traditional latex condoms. It feels as real as it gets! It even beats Durex Avanti (50 microns thick) at a world class 15 microns thick!
The condoms are hypoallergenic, colourless, odourless and can be used with ANY lubricant.

The rest is up to you.
More at XEssentials.com
(hat tip: Gizmodo)

intelliclean crest The IntelliClean SystemThe new IntelliClean system from Sonicare and Crest, and manufactured by Philips is the first integrated power toothbrush and toothpaste dispensing system.
From the product’s website:

This system combines the patented Sonicare high-speed bristle motion with a new specially formulated liquid toothpaste from Crest. The push of a button delivers noticeable results.
Healthy gums
Designed to provide a deep, thorough clean throughout your mouth, the IntelliClean system is proven to be gentle on teeth and gums.
Improved oral health
The IntelliClean system has been proven to reduce gingivitis and promote healthy gums. Crest liquid toothpaste delivers the additional benefit of anticavity protection.
Fresher breath
Dispensing an added dose of Crest liquid toothpaste during brushing provides an extra burst of freshness.
Anti-cavity protection
The specially formulated Crest liquid toothpaste with sodium fluoride fights cavities.
Naturally whiter teeth
Significantly removes coffee, tea and tobacco stains, for naturally whiter teeth.
The invigorating feeling of a sonicare toothbrush
This stimulating feeling of clean will motivate you to brush longer.

This cool system is described as “.. one step closer to daily flossing.” So either the system, or $1.39 per 500 yards of one-step-better-than-this-system floss. The choice is yours. Check your local Walgreens, since both the floss and the IntelliClean system should be now available.
More at product’s page

vein viewer Video of VeinViewerRemember the vein contrast enhancer, the system that projects the location of hidden veins onto the patient’s skin? Well, the device is now called VeinViewer, and is being developed by Memphis-based Luminetx Corp.
WISTV of Columbia, SC has a video demonstrating this amazing technology. Go here and click on ‘Dawndy Mercer on the Vein Viewer’ to watch the video.
UPDATE: Video over at WISTV has been taken off.
Medgadget coverage: Vein Contrast Enhancer; VeinViewer Shipped!
745653 Video of VeinViewer
More at Luminetx

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cook afp Surgisis AFP Fistula PlugCook Inc. has received FDA clearance for its fistula plug. From the press release:

The U.S. Food and Drug Administration has cleared the Surgisis(R) AFP(TM) Fistula Plug as the first and only surgical device for repair of fistulas, Cook Biotech Incorporated announced today.
A fistula is an abnormal channel that develops between body organs. The most common fistulas occur from the intestine to an opening in the skin. The presence of a fistula can be painful and seriously impact a patient’s quality of life. Unfortunately, current treatments involving either an extensive surgical procedure or use of fibrin glue do not always yield satisfactory results, leaving the patient with a chronic, debilitating problem. More than 125,000 surgeries to repair fistulas are performed each year in the United States.
Surgisis AFP, sold by Cook Incorporated’s Surgical Division, is a cone-shaped medical device that has been specifically designed to allow a surgeon to easily place it into a fistula channel. Once in place, Surgisis AFP serves as a bio-scaffold to facilitate well-organized tissue regeneration to close the fistula.
At the annual meeting of the American Society of Colorectal Surgeons in Philadelphia next month, Eric Johnson, M.D., Janette Gaw, M.D., and David Armstrong M.D., will present data from a clinical study that evaluated the efficacy of the Surgisis AFP device versus fibrin glue in closing fistulas. The study found an 87 percent fistula closure rate in the patient group treated with Surgisis AFP, while patients receiving fibrin glue had only a 40 percent fistula closure rate at three months.
“Surgisis AFP is easily placed, is tolerated well by patients and is showing significant improvement over conventional therapies,” explained Dr. David Armstrong, Program Director of the Georgia Colon and Rectal Surgical Clinic in Atlanta, Georgia.

Cook, Inc. website

This is not good:

“We performed the wrong operation on you, we didn’t look at your folder,” a doctor is alleged to have told an aged man whose testicles had been removed instead of his prostate gland.

(hat tip: Kevin, M.D. )

The New York Times Magazine looks at the history of autopsy, and the social and fiscal constraints that prevent our society from fully using this important medical tool. Some history, taken from the article:

The autopsy’s intellectual founder was Giovanni Morgagni, a physician and professor at the University of Padua who wrote one of the most gruesome, humane and riveting early texts of modern medicine, ”The Seats and Causes of Disease Investigated by Anatomy.” Published in 1761, when Morgagni was 79, the book describes nearly 700 autopsies he performed. His lucid, compassionate accounts demonstrated irrefutably that illness works in traceable, physical ways; medicine, therefore, should be an empirical endeavor aimed at particular physical processes rather than ”humors,” spirits or other intangibles.
Morgagni’s perspective was carried into the present era by William Osler, a Canadian who practiced and taught medicine in the United States in the late 1800′s. Osler exerted more influence on 20th-century medicine than any other doctor, primarily by creating at Johns Hopkins Medical School the model for medical education still used today, with students seeing patients beginning their third year and training in internships and residencies after graduating. Osler placed the autopsy at the center of this education, performing more than a thousand post-mortems himself and insisting that staff members and students do them regularly. Tracking the necrotic footprints of their own missteps, he believed, would teach them lessons far more memorable than any text could.
Osler’s argument was strengthened in the early 1910′s by the work of Richard Clarke Cabot, who reviewed the records and autopsies of thousands of patients at Massachusetts General Hospital and found that the autopsies showed clinical diagnoses to be wrong about 40 percent of the time — the finding replicated many times since. His reports helped solidify the autopsy’s central role in medical education and practice. Autopsy rates began to rise. By World War II, they were nearing 50 percent, and autopsies had become standard in medical schools and many hospitals, where weekly mortality and morbidity conferences often focused on what autopsies had revealed about the diagnosis and treatment of patients’ illnesses.
That midcentury peak helped drive remarkable medical progress. In 1945, for instance, the chance of survival for a patient with an aortic aneurysm was little better than it was a century earlier. But in the 50′s and 60′s, surgeons like Michael DeBakey, a pioneering cardiovascular surgeon, learned through trial and error — the errors offering their lessons only through autopsy — how to repair and replace first lower sections of the aorta in the abdomen and then, working up toward the heart, the biggest, most pressurized and most vital sections. By 1960, aortic repairs were routine. By 1970, the lessons learned helped make open-heart surgery common as well.

Read the whole article.
If you would like to learn more about the (forensic) autopsy process step by step, you can participate in Dr. Baden’s HBO interactive feature.
On this positive vibe we would like to thank you for stopping by. “The good old days” feature means that the working week is over, and a great spring weekend is ahead. Have a nice one!
(hat tip: Rebel Doctor)

RheoOnProsthesis Adaptive Prosthetics
Another promising medgadget spotlighted in MIT’s Technology Review is a new generation of prosthetics with sensors. One of the scientists involved is MIT’s Hugh Herr:

Some of the latest prosthetic knees on the market already have microprocessors built into them that can be programmed to help the limbs move more naturally. But Herr has taken this idea one step further. He has developed a knee with built-in sensors that can measure how far the knee is bent, as well as the amount of force the user applies to it while walking. This artificial knee–recently commercialized by the Icelandic company Ossur–also contains a computer chip that analyzes the sensor data to create a model of the user’s gait, and adapt the movement and resistance of the knee accordingly…
…Now Herr is working to distribute those sensors beyond the knee joint, using them to detect not just the mechanical forces of the body but also neural signals from the muscles near the joint. This work is part of an emerging discipline called biomechatronics, in which researchers are building robotic prostheses that can communicate with users’ nervous systems. In five to seven years, predicts Herr, spinal-cord injury patients will move their limbs again by controlling robotic exoskeletons strapped onto them (or at least they will in research settings).

We’ve blogged before about the high expectations on these new prostheses. But Herr has a personal stake in making it happen: he’s a double-amputee, and looks forward to being among the first test subjects for his prosthetic device.
More at Ossur